Since 1989-90, the Pittsburgh Penguins have the most wins by a team when the goal differential has been 5 or above goals, with 107 wins.

Interpreted as:

most regular-season wins by 5+ goals since 1990

	TEAM	W	DIFF	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Penguins	107	615	107	0	0	0	214	1.000	0	0	767	152	40.3	91.6	34.34	20.9	28.82	.951
2	Red Wings	102	589	102	0	0	0	204	1.000	0	0	718	129	33.9	92.3	33.86	20.8	25.43	.950
3	Sabres	97	551	97	0	0	0	194	1.000	0	0	673	122	36.3	92.5	33.13	20.9	28.26	.955
4	Avalanche	95	532	95	0	0	0	190	1.000	0	0	630	98	38.9	92.2	33.72	19.7	27.86	.963
5	Rangers	91	501	91	0	0	0	182	1.000	0	0	607	106	36.0	91.0	33.36	20.0	29.29	.960
6	Blues	88	478	88	0	0	0	176	1.000	0	0	595	117	38.2	91.3	31.60	21.4	27.05	.951
7	Maple Leafs	85	484	85	0	0	0	170	1.000	0	0	558	74	37.2	95.0	32.94	19.9	28.48	.969
8	Devils	83	459	83	0	0	0	166	1.000	0	0	543	84	37.0	91.2	34.25	19.1	24.92	.959
9	Bruins	83	477	83	0	0	0	166	1.000	0	0	558	81	38.4	91.3	33.81	19.9	26.13	.963
10	Flames	82	473	82	0	0	0	164	1.000	0	0	570	97	34.6	91.5	34.48	20.2	26.04	.955
11	Oilers	82	455	82	0	0	0	164	1.000	0	0	559	104	34.9	91.4	31.88	21.4	28.82	.956
12	Canucks	79	450	79	0	0	0	158	1.000	0	0	521	71	35.4	92.2	31.86	20.7	27.39	.967
13	Capitals	79	461	79	0	0	0	158	1.000	0	0	552	91	40.9	92.0	32.22	21.7	28.57	.960
14	Kings	78	445	78	0	0	0	156	1.000	0	0	537	92	36.6	90.6	34.56	19.9	28.73	.959
15	Flyers	75	418	75	0	0	0	150	1.000	0	0	492	74	38.0	92.1	31.84	20.6	27.29	.964
16	Stars	73	411	73	0	0	0	146	1.000	0	0	496	85	37.7	91.9	32.60	20.8	24.95	.953
17	Senators	71	401	71	0	0	0	142	1.000	0	0	475	74	32.0	94.3	32.99	20.3	27.30	.962
18	Sharks	68	379	68	0	0	0	136	1.000	0	0	439	60	33.9	91.8	32.57	19.8	27.60	.968
19	Blackhawks	68	376	68	0	0	0	136	1.000	0	0	456	80	34.0	87.9	31.85	21.1	27.37	.957
20	Lightning	65	361	65	0	0	0	130	1.000	0	0	420	59	41.1	92.9	31.74	20.4	26.92	.966
21	Canadiens	58	346	58	0	0	0	116	1.000	0	0	420	74	39.4	87.7	32.17	22.5	27.90	.954
22	Panthers	57	311	57	0	0	0	114	1.000	0	0	372	61	35.8	90.4	33.82	19.3	30.07	.964
23	Predators	56	307	56	0	0	0	112	1.000	0	0	358	51	30.5	91.5	31.48	20.3	28.36	.968
24	Islanders	53	298	53	0	0	0	106	1.000	0	0	368	70	29.8	91.0	31.32	22.2	27.79	.952
25	Coyotes	53	297	53	0	0	0	106	1.000	0	0	342	45	28.4	90.6	31.32	20.6	30.15	.972