Between the 2010-11 and 2021-22 seasons, the Pittsburgh Penguins had the most wins by a team, with 542 wins.

Interpreted as:

most regular-season wins from 2010-11 to 2021-22

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Penguins	542	911	279	90	1,174	.644	54	37	2,865	2,428	437	21.3	83.0	32.50	9.7	30.14	.912
2	Lightning	532	912	299	81	1,145	.628	45	40	2,882	2,518	364	20.9	81.7	30.25	10.4	29.99	.908
3	Bruins	531	912	276	105	1,167	.640	39	50	2,734	2,245	489	20.9	83.3	32.75	9.2	29.39	.916
4	Capitals	529	911	279	103	1,161	.637	52	42	2,778	2,444	334	21.5	82.1	30.02	10.2	30.08	.911
5	Blues	521	913	293	99	1,141	.625	50	42	2,662	2,333	329	20.7	83.1	30.27	9.6	28.40	.910
6	Rangers	495	912	333	84	1,074	.589	46	43	2,628	2,402	226	19.2	81.7	30.10	9.6	30.79	.914
7	Predators	486	911	315	110	1,082	.594	49	50	2,578	2,430	148	18.6	80.6	30.35	9.3	30.12	.911
8	Wild	481	911	330	100	1,062	.583	48	46	2,552	2,463	89	18.7	80.8	29.28	9.6	29.89	.910
9	Sharks	472	912	339	101	1,045	.573	57	44	2,570	2,517	53	20.1	81.8	31.92	8.8	29.27	.906
10	Blackhawks	469	912	330	113	1,051	.576	55	42	2,672	2,597	75	18.8	79.3	31.69	9.2	31.10	.908
11	Ducks	464	913	332	117	1,045	.572	48	48	2,457	2,506	-49	18.3	81.9	29.19	9.2	30.58	.910
12	Stars	462	911	345	104	1,028	.564	39	40	2,536	2,541	-5	19.0	80.4	30.19	9.2	30.25	.908
13	Avalanche	457	912	364	91	1,005	.551	46	22	2,619	2,644	-25	19.2	80.5	30.62	9.4	31.56	.908
14	Kings	456	912	352	104	1,016	.557	43	49	2,356	2,309	47	17.7	82.3	31.02	8.3	28.24	.910
15	Flames	456	912	361	95	1,007	.552	40	43	2,613	2,577	36	18.8	81.2	30.17	9.5	29.41	.904
16	Maple Leafs	455	912	351	106	1,016	.557	42	49	2,746	2,716	30	20.1	80.3	30.73	9.8	32.11	.907
17	Jets	455	913	360	98	1,008	.552	43	41	2,641	2,636	5	19.1	79.5	30.67	9.4	31.13	.907
18	Flyers	442	911	345	124	1,008	.553	38	69	2,603	2,669	-66	19.1	80.1	31.04	9.2	30.21	.903
19	Islanders	442	910	353	115	999	.549	55	54	2,537	2,609	-72	18.4	80.6	30.15	9.2	30.96	.907
20	Panthers	442	911	349	120	1,004	.551	54	64	2,582	2,647	-65	18.5	80.1	31.93	8.9	31.16	.907
21	Canucks	441	911	363	107	989	.543	53	53	2,467	2,541	-74	19.3	81.6	30.10	9.0	31.23	.911
22	Hurricanes	439	910	348	123	1,001	.550	34	43	2,503	2,527	-24	18.1	82.7	31.92	8.6	29.53	.906
23	Blue Jackets	436	912	376	100	972	.533	51	42	2,500	2,646	-146	17.1	80.4	30.35	9.0	31.25	.907
24	Canadiens	435	913	364	114	984	.539	45	42	2,465	2,556	-91	17.3	81.4	30.81	8.8	30.58	.908
25	Red Wings	405	913	383	125	935	.512	51	49	2,403	2,711	-308	17.9	79.7	29.84	8.8	30.63	.903