The Buffalo Sabres had their most wins in a season in 2006-07, with 53 wins.

Interpreted as:

most wins in a regular season sabres all-time

	TEAM	W	SEASON	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Sabres	53	2006-07	82	22		7	113	.689	10	4	298	238	60	17.4	81.3	29.48	12.3	31.00	.906
2	Sabres	52	2005-06	82	24		6	110	.671	5	5	276	234	42	21.2	86.6	30.61	11.0	30.51	.906
3	Sabres	49	1974-75	80	16	15		113	.706			354	240	114			36.96	12.0	26.08	.885
4	Sabres	48	1983-84	80	25	7		103	.644			315	257	58	22.0	81.9	29.86	13.2	26.84	.880
5	Sabres	48	1976-77	80	24	8		104	.650			301	220	81			31.60	11.9	25.79	.893
6	Sabres	47	1979-80	80	17	16		110	.688			318	201	117	24.4	82.9	29.33	13.6	23.99	.895
7	Sabres	46	2000-01	82	30	5	1	98	.598			218	184	34	16.1	88.0	26.88	9.9	26.77	.916
8	Sabres	46	1975-76	80	21	13		105	.656			339	240	99			33.96	12.5	26.25	.886
9	Sabres	45	2009-10	82	27		10	100	.610	4	6	231	201	30	17.6	86.6	31.56	8.9	31.38	.922
10	Sabres	45	1989-90	80	27	8		98	.613			286	248	38	22.1	83.5	30.20	11.8	31.55	.902
11	Sabres	44	1977-78	80	19	17		105	.656			288	215	73	22.2	85.8	30.99	11.6	27.86	.904
12	Sabres	43	2010-11	82	29		10	96	.585	5	1	240	228	12	19.4	83.0	32.80	8.9	30.66	.909
13	Sabres	43	1993-94	84	32	9		95	.565			282	218	64	22.6	84.7	28.20	11.9	29.31	.911
14	Sabres	42	2022-23	82	33		7	91	.555	3	3	293	297	-4	23.4	73.0	32.50	11.0	33.05	.890
15	Sabres	41	2008-09	82	32		9	91	.555	8	5	242	229	13	20.9	81.8	30.55	9.7	31.40	.911
16	Sabres	40	1996-97	82	30	12		92	.561			237	208	29	13.2	83.8	25.49	11.3	33.27	.924
17	Sabres	39	2023-24	82	37		6	84	.512	2	1	244	243	1	16.6	79.8	30.90	9.6	29.28	.899
18	Sabres	39	2011-12	82	32		11	89	.543	7	7	211	223	-12	17.1	81.7	29.23	8.8	31.35	.913
19	Sabres	39	2007-08	82	31		12	90	.549	4	9	251	233	18	18.0	83.2	30.22	10.1	28.37	.900
20	Sabres	39	1981-82	80	26	15		93	.581			307	273	34	21.6	79.3	29.28	13.1	29.00	.882
21	Sabres	39	1980-81	80	20	21		99	.619			327	250	77	23.9	83.2	31.00	13.2	27.94	.888
22	Sabres	38	1992-93	84	36	10		86	.512			335	297	38	20.3	83.5	31.80	12.5	31.88	.889
23	Sabres	38	1988-89	80	35	7		83	.519			291	299	-8	20.5	79.0	27.90	13.0	29.73	.874
24	Sabres	38	1984-85	80	28	14		90	.563			290	237	53	24.1	82.4	28.86	12.6	23.76	.875
25	Sabres	38	1982-83	80	29	13		89	.556			318	285	33	21.7	82.3	30.08	13.2	26.46	.865