The Pittsburgh Penguins had the highest goal differential by a team in a game in 2021-22, with a differential of 9 goals versus the Red Wings on March 27, 2022.

NHL largest margin of victory single regular-season game 2021-22

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Penguins	9	3/27/2022	PIT	vs	DET	W 11-2	11	2	3	6	1	5	35	35
2	Canadiens	8	4/29/2022	MTL	vs	FLA	W 10-2	10	2	1	2	1	1	37	39
3	Flames	8	4/16/2022	CGY	vs	ARI	W 9-1	9	1	0	2	0	2	41	26
4	Predators	8	3/5/2022	NSH	@	SJS	W 8-0	8	0	1	4	0	3	36	20
5	Lightning	7	4/21/2022	TBL	vs	TOR	W 8-1	8	1	3	5	1	5	36	37
6	Capitals	7	4/12/2022	WSH	vs	PHI	W 9-2	9	2	1	4	1	2	37	21
7	Bruins	7	3/31/2022	BOS	vs	NJD	W 8-1	8	1	1	3	0	3	40	26
8	Coyotes	7	3/8/2022	ARI	@	DET	W 9-2	9	2	0	1	2	4	30	28
9	Bruins	7	2/28/2022	BOS	@	LAK	W 7-0	7	0	2	3	0	2	32	34
10	Panthers	7	1/15/2022	FLA	vs	CBJ	W 9-2	9	2	1	4	1	4	51	30
11	Canucks	6	4/14/2022	VAN	vs	ARI	W 7-1	7	1	3	4	1	2	27	22
12	Avalanche	6	4/13/2022	COL	vs	LAK	W 9-3	9	3	2	2	0	2	35	32
13	Islanders	6	3/10/2022	NYI	vs	CBJ	W 6-0	6	0	2	3	0	5	33	25
14	Canucks	6	2/24/2022	VAN	vs	CGY	W 7-1	7	1	3	7	0	1	38	30
15	Hurricanes	6	2/10/2022	CAR	@	BOS	W 6-0	6	0	2	4	0	4	43	34
16	Flames	6	2/9/2022	CGY	vs	VGK	W 6-0	6	0	1	2	0	2	33	28
17	Devils	6	2/8/2022	NJD	@	MTL	W 7-1	7	1	1	2	0	3	34	31
18	Maple Leafs	6	2/1/2022	TOR	@	NJD	W 7-1	7	1	0	2	0	3	36	32
19	Flames	6	1/26/2022	CGY	@	CBJ	W 6-0	6	0	0	3	0	1	62	23
20	Wild	6	1/24/2022	MIN	vs	MTL	W 8-2	8	2	1	5	0	2	39	21
21	Flames	6	1/24/2022	CGY	vs	STL	W 7-1	7	1	2	5	0	2	48	21
22	Lightning	6	1/22/2022	TBL	@	SJS	W 7-1	7	1	1	2	0	2	31	28
23	Panthers	6	1/20/2022	FLA	@	EDM	W 6-0	6	0	3	5	0	3	28	40
24	Hurricanes	6	1/18/2022	CAR	@	BOS	W 7-1	7	1	2	3	1	5	34	32
25	Panthers	6	1/14/2022	FLA	vs	DAL	W 7-1	7	1	1	2	0	2	39	30