Elvis Merzlikins had the most saves in a game in 2021-22, with 56 saves against the Flames on January 26, 2022.

Interpreted as:

NHL most saves by a player in a single regular-season game 2021-22

	NAME	SV	DATE	TM		OPP	DEC	SA	SV%	GA	GAA	SHO	MIN
1	Elvis Merzlikins E. Merzlikins	56	1/26/2022	CBJ	vs	CGY	L	62	.903	6	6.00	0	60
2	Casey DeSmith C. DeSmith	52	4/21/2022	PIT	vs	BOS	W	52	1.000	0	0.00	1	60
3	John Gibson J. Gibson	52	4/12/2022	ANA	@	FLA	O	55	.945	3	2.83	0	64
4	Thatcher Demko T. Demko	51	2/12/2022	VAN	vs	TOR	W	53	.962	2	2.00	0	60
5	Darcy Kuemper D. Kuemper	49	4/9/2022	COL	@	EDM	W	50	.980	1	0.92	0	65
6	Jake Allen J. Allen	49	3/26/2022	MTL	vs	TOR	W	51	.961	2	2.00	0	60
7	Sam Montembeault S. Montembeault	49	1/20/2022	MTL	@	VGK	O	53	.925	4	3.88	0	62
8	Sam Montembeault S. Montembeault	48	1/18/2022	MTL	@	DAL	W	51	.941	3	3.02	0	60
9	Ville Husso V. Husso	48	12/4/2021	STL	@	FLA	O	51	.941	3	2.77	0	65
10	Elvis Merzlikins E. Merzlikins	47	4/5/2022	CBJ	@	PHI	W	49	.959	2	2.00	0	60
11	Alex Nedeljkovic A. Nedeljkovic	47	4/5/2022	DET	vs	BOS	W	50	.940	3	3.01	0	60
12	Juuse Saros J. Saros	47	4/5/2022	NSH	vs	MIN	W	49	.959	2	2.01	0	60
13	Carter Hart C. Hart	47	3/8/2022	PHI	vs	VGK	W	48	.979	1	1.00	0	60
14	Spencer Martin S. Martin	47	1/25/2022	VAN	vs	EDM	O	50	.940	3	2.80	0	64
15	Sergei Bobrovsky S. Bobrovsky	47	1/4/2022	FLA	vs	CGY	W	49	.959	2	2.00	0	60
16	Anton Forsberg A. Forsberg	47	12/2/2021	OTT	@	CAR	W	49	.959	2	2.00	0	60
17	Jake Allen J. Allen	47	11/27/2021	MTL	@	PIT	W	50	.940	3	3.03	0	59
18	Karel Vejmelka K. Vejmelka	46	4/18/2022	ARI	vs	CAR	L	51	.902	5	5.06	0	59
19	Alex Nedeljkovic A. Nedeljkovic	46	4/14/2022	DET	@	CAR	W	46	1.000	0	0.00	1	60
20	Anton Forsberg A. Forsberg	46	3/26/2022	OTT	vs	FLA	O	49	.939	3	2.77	0	65
21	Marc-Andre Fleury M. Fleury	46	3/15/2022	CHI	vs	BOS	O	48	.958	2	1.95	0	62
22	Darcy Kuemper D. Kuemper	46	3/13/2022	COL	vs	CGY	W	46	1.000	0	0.00	1	60
23	Jean-Francois Berube J. Berube	46	2/25/2022	CBJ	@	CAR	L	50	.920	4	4.00	0	60
24	Jake Oettinger J. Oettinger	46	2/15/2022	DAL	@	COL	W	47	.979	1	1.00	0	60
25	Jacob Markstrom J. Markstrom	46	2/10/2022	CGY	vs	TOR	W	48	.958	2	2.00	0	60