Martin Brodeur has lost the most career games, with 397 losses.

NHL player most regular-season losses all-time

	NAME	L	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Martin Brodeur M. Brodeur	397	1,266	2	45	47		122	1															58:48
2	Roberto Luongo R. Luongo	392	1,044	0	23	23	0	46	0	3	0	0	0	0	0		0	0		0	0	0	43	57:21
3	Curtis Joseph C. Joseph	352	943	0	31	31		126																57:19
4	Gilles Meloche G. Meloche	351	788	0	22	22		109																57:31
5	Gump Worsley G. Worsley	348	860	0	3	3		137																58:19
6	John Vanbiesbrouck J. Vanbiesbrouck	346	882	0	35	35		310																57:12
7	Sean Burke S. Burke	341	820	0	28	28		310																56:38
8	Terry Sawchuk T. Sawchuk	336	971	0	7	7		225																58:52
9	Nikolai Khabibulin N. Khabibulin	334	799	0	18	18		134																57:05
10	Marc-Andre Fleury M. Fleury	331	1,032	0	22	22	0	84	0	2	0	0	0	0	1	0.0	1	2	50.0	2	0	11	132	57:51
11	Harry Lumley H. Lumley	329	803	0	0	0		93																59:49
12	Glenn Hall G. Hall	326	906	0	9	9		98																59:00
13	Ed Belfour E. Belfour	320	963	0	34	34		380																57:50
14	Patrick Roy P. Roy	315	1,029	0	45	45		262																58:31
15	Henrik Lundqvist H. Lundqvist	310	887	0	27	27	0	18	0	2	0	1	0	0	0		0	0		0	0	0	78	58:25
16	Tony Esposito T. Esposito	306	886	0	25	25		31																59:14
17	Olie Kolzig O. Kolzig	297	719	0	17	17		107																57:57
18	Grant Fuhr G. Fuhr	295	868	0	47	47		120																56:22
19	Rogie Vachon R. Vachon	293	795	0	10	10		47																58:07
20	Ryan Miller R. Miller	289	796	0	12	12	0	48	0	1	0	0	0	0	0		113	277	40.8	0	0	20	49	57:58
21	Tomas Vokoun T. Vokoun	288	700	0	23	23		125																56:42
22	Jonathan Quick J. Quick	285	788	0	21	21	0	78	0	3	0	0	0	0	1	0.0	0	0		0	0	1	174	58:06
23	Greg Millen G. Millen	284	604	0	18	18		72																58:27
24	Bill Ranford B. Ranford	279	647	0	24	24		65																55:32
25	Tom Barrasso T. Barrasso	277	777	0	48	48		437																56:48