Between the 1999-00 and 2008-09 seasons, Joe Sakic had the highest plus/minus with 40+ goals and 100+ points in a season, at +45 in 2000-01.

players with 40 or more goals and 100 or more points and the best plus-minus in a season in the 2000's

	NAME	+/-	G	P	SEASON	TM	GP	A	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Joe Sakic J. Sakic	+45	54	118	2000-01	COL	82	64	30	19	27	3	3	12	2	332	16.3	1,214	2,292	53.0	44	54	79	54	23:01
2	Jaromir Jagr J. Jagr	+34	54	123	2005-06	NYR	82	69	72	24	28	0	0	9	2	368	14.7	1	6	16.7	23	13	45	111	22:05
3	Dany Heatley D. Heatley	+31	50	105	2006-07	OTT	82	55	74	17	22	3	1	10	0	310	16.1	23	60	38.3	93	25	68	58	21:02
4	Daniel Alfredsson D. Alfredsson	+29	43	103	2005-06	OTT	77	60	50	16	32	5	1	8	0	249	17.3	9	44	20.5	43	31	75	79	21:41
5	Dany Heatley D. Heatley	+29	50	103	2005-06	OTT	82	53	86	23	20	2	2	7	0	300	16.7	89	166	53.6	62	23	32	72	21:09
6	Alex Ovechkin A. Ovechkin	+28	65	112	2007-08	WSH	82	47	40	22	15	0	0	11	2	446	14.6	7	18	38.9	220	44	68	93	23:06
7	Jaromir Jagr J. Jagr	+19	52	121	2000-01	PIT	81	69	42	14	27	1	1	10	0	317	16.4	0	2	0.0	25	27	38	112	23:19
8	Marian Hossa M. Hossa	+18	43	100	2006-07	ATL	82	57	49	17	27	3	1	5	0	340	12.6	4	18	22.2	90	28	94	71	21:41
9	Evgeni Malkin E. Malkin	+16	47	106	2007-08	PIT	82	59	78	17	23	0	0	5	0	272	17.3	350	890	39.3	49	40	69	76	21:19
10	Alex Ovechkin A. Ovechkin	+8	56	110	2008-09	WSH	79	54	72	19	27	1	0	10	2	528	10.6	8	32	25.0	243	32	60	107	23:00
11	Martin St. Louis M. St. Louis	+7	43	102	2006-07	TBL	82	59	28	14	16	5	6	7	2	273	15.8	7	20	35.0	44	44	83	92	24:09
12	Markus Naslund M. Naslund	+6	48	104	2002-03	VAN	82	56	52	24	30	0	0	12	1	294	16.3	2	6	33.3	4	3	11	16	19:54
13	Vincent Lecavalier V. Lecavalier	+2	52	108	2006-07	TBL	82	56	44	16	20	5	4	7	1	339	15.3	770	1,653	46.6	112	22	51	78	22:36
14	Alex Ovechkin A. Ovechkin	+2	52	106	2005-06	WSH	81	54	52	21	31	3	0	5	2	425	12.2	2	16	12.5	172	20	69	88	21:37
15	Eric Staal E. Staal	-8	45	100	2005-06	CAR	82	55	81	19	21	4	0	4	0	279	16.1	557	1,309	42.6	43	36	49	37	19:39