Gilbert Perreault has collected the most career goals for the Sabres, with 512 scored.

	NAME	G	GP	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Gilbert Perreault G. Perreault	512	1,191	814	1,326	+41	500	134	298	8	4	81	0	3,077	16.6
2	Richard Martin R. Martin	382	681	313	695	+12	475	114	103	0	0	47		2,515	15.2
3	Dave Andreychuk D. Andreychuk	368	837	436	804	+22	592	161	180	0	0	38	4	2,342	15.7	93	187	49.7	36	25	31	36	12:00
4	Danny Gare D. Gare	267	503	233	500	+187	686	66	58	1	1	35		1,780	15.0
5	Thomas Vanek T. Vanek	254	598	243	497	+29	362	106	78	3	0	41	6	1,685	15.1	46	139	33.1	257	166	271	446	16:48
6	Craig Ramsay C. Ramsay	252	1,070	420	672	+324	201	17	48	27	20	32	0	1,617	15.6
7	Mike Foligno M. Foligno	247	664	264	511	+115	1,448	62	61	2	4	42	1	1,450	17.0
8	Miroslav Satan M. Satan	224	578	232	456	+44	233	74	75	15	7	33	2	1,560	14.4	11	41	26.8	140	136	188	351	20:37
9	Rene Robert R. Robert	222	524	330	552	+47	401	53	144	0	0	32		1,754	12.7
10	Jason Pominville J. Pominville	217	733	304	521	+20	159	48	106	10	5	24	5	1,908	11.4	436	981	44.4	332	405	337	277	17:35
11	Don Luce D. Luce	216	766	310	526	+214	304	22	22	25	18	30		1,774	12.2
12	Alexander Mogilny A. Mogilny	211	381	233	444	+44	203	78	88	3	4	29	0	1,333	15.8
13	Phil Housley P. Housley	178	608	380	558	+3	386	61	189	4	2	25	3	1,597	11.1
14	Ric Seiling R. Seiling	176	664	200	376	+116	524	26	23	9	9	23	0	1,125	15.6
15	Donald Audette D. Audette	166	421	131	297	-6	335	65	45	1	0	30	3	1,103	15.0	0	1	0.0	1	1	6	10	17:25
16	Derek Roy D. Roy	161	549	266	427	+39	331	45	92	8	3	30	6	1,271	12.7	4,266	8,595	49.6	272	311	346	457	19:05
17	Pat LaFontaine P. LaFontaine	158	268	227	385	+3	207	66	111	6	0	22	0	865	18.3
18	Jeff Skinner J. Skinner	153	427	138	291	-34	173	30	34	0	0	18	5	1,277	12.0	502	1,095	45.8	156	94	243	224	16:50
19	Tage Thompson T. Thompson	145	355	122	267	-40	162	44	31	5	0	15	2	1,080	13.4	1,259	2,994	42.1	313	106	166	160	16:38
20	Drew Stafford D. Stafford	145	563	177	322	-20	327	36	40	2	1	19	2	1,336	10.9	344	723	47.6	575	140	181	233	15:58
21	Jack Eichel J. Eichel	139	375	216	355	-69	142	41	86	1	2	25	8	1,324	10.5	2,465	5,585	44.1	251	203	205	309	20:19
22	Jochen Hecht J. Hecht	138	613	207	345	+67	322	20	36	7	5	17	2	1,602	8.6	1,548	3,622	42.7	297	303	264	314	17:44
23	Sam Reinhart S. Reinhart	134	454	161	295	-97	90	46	45	0	0	19	0	988	13.6	396	1,021	38.8	187	214	152	178	18:06
24	Maxim Afinogenov M. Afinogenov	134	569	200	334	-26	440	32	66	1	0	20	4	1,376	9.7	11	44	25.0	248	105	168	481	14:48
25	Jim Lorentz J. Lorentz	134	487	197	331	-6	126	46	50	1	1	25		917	14.6