LaDainian Tomlinson rushed for the most yards in 1999, with 1,850 yards.

	NAME	RUSH YDS	SEASON	TM	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	AVG	REC YDS/G	REC TD
1	LaDainian Tomlinson L. Tomlinson	1,850	1999	TCU	11	268	6.9	168.2	18	55	12	4.6	5.0	0
2	Ron Dayne R. Dayne	1,834	1999	WIS	11	303	6.1	166.7	19	9	1	9.0	0.8	0
3	Thomas Jones T. Jones	1,798	1999	UVA	11	334	5.4	163.5	16	239	22	10.9	21.7	1
4	Travis Prentice T. Prentice	1,659	1999	M-OH	11	354	4.7	150.8	17	270	19	14.2	24.5	4
5	Lamont Jordan L. Jordan	1,632	1999	MD	11	266	6.1	148.4	16	208	19	10.9	18.9	1
6	Trung Canidate T. Canidate	1,602	1999	ARIZ	12	253	6.3	133.5	11	253	30	8.4	21.1	1
7	Demario Brown D. Brown	1,536	1999	USU	11	279	5.5	139.6	14	282	26	10.8	25.6	1
8	Darren Davis D. Davis	1,388	1999	ISU	11	287	4.8	126.2	14	160	21	7.6	14.5	2
9	Shaun Alexander S. Alexander	1,383	1999	ALA	11	302	4.6	125.7	19	323	25	12.9	29.4	4
10	Thomas Hamner T. Hamner	1,362	1999	MINN	11	288	4.7	123.8	10	298	19	15.7	27.1	3
11	Hodges Mitchell H. Mitchell	1,343	1999	TEX	13	256	5.2	103.3	9	343	32	10.7	26.4	1
12	Ken Simonton K. Simonton	1,329	1999	ORST	11	276	4.8	120.8	17	194	18	10.8	17.6	0
13	Frank Moreau F. Moreau	1,289	1999	LOU	10	233	5.5	128.9	17	285	38	7.5	28.5	0
14	Paul Smith P. Smith	1,258	1999	UTEP	12	272	4.6	104.8	12	84	7	12.0	7.0	1
15	Anthony Thomas A. Thomas	1,257	1999	MICH	11	283	4.4	114.3	16	166	29	5.7	15.1	0
16	Robert Cooper R. Cooper	1,245	1999	CIN	10	228	5.5	124.5	7	180	22	8.2	18.0	2
17	Ketric Sanford K. Sanford	1,199	1999	HOU	11	224	5.4	109.0	12	113	16	7.1	10.3	0
18	Chester Taylor C. Taylor	1,176	1999	TOL	11	182	6.5	106.9	12	47	8	5.9	4.3	0
19	Chris Lemon C. Lemon	1,170	1999	NEV	11	238	4.9	106.4	12	184	20	9.2	16.7	1
20	Kevin McDougal K. McDougal	1,164	1999	CSU	10	207	5.6	116.4	8	58	8	7.3	5.8	0
21	Morgan Kane M. Kane	1,161	1999	WAKE	11	275	4.2	105.5	10	95	18	5.3	8.6	2
22	Chad Morton C. Morton	1,141	1999	USC	12	262	4.4	95.1	15	79	17	4.6	6.6	0
23	Reuben Droughns R. Droughns	1,139	1999	ORE	11	256	4.4	103.5	9	164	14	11.7	14.9	1
24	Avon Cobourne A. Cobourne	1,138	1999	WVU	10	224	5.1	113.8	10	126	16	7.9	12.6	0
25	Robert Sanford R. Sanford	1,137	1999	WMU	12	221	5.1	94.8	8	145	21	6.9	12.1	2