Liverpool had their highest goal differential in a Champions League match against Big Six opponents against Man City on April 4, 2018, with a differential of 3 goals.

liverpool biggest win in a game against big six

	CLUB	GD	DATE		OPP	RESULT	G	SH	SOT	PASS	PASS-ATT	POSS%	FOUL	YC	SUBS
1	Liverpool	3	4/4/2018	vs	Man City	W 3-0	3	9	5	270	379	34.0	6	1	3
2	Liverpool	2	6/1/2019	@	Tottenham	W 2-0	2	14	3	175	272	35.4	6	0	3
3	Liverpool	2	4/8/2008	vs	Arsenal	W 4-2	4							0	3
4	Liverpool	1	4/10/2018	@	Man City	W 2-1	2	5	3	211	309	31.7	7	4	3
5	Liverpool	1	5/1/2007	vs	Chelsea	W 1-0 (4-1 Pen)	1							2	3
6	Liverpool	1	5/3/2005	vs	Chelsea	W 1-0	1							1	3