Domenico Berardi has the most career shots blocked in Serie A, with 277 shots blocked.

Interpreted as:

most blocks by a player of all-time

	NAME	SH-BLK	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Domenico Berardi D. Berardi	277	292	23,511	275	107	0.37	74	181	42	4	921	326	19	16,073	820	112
2	Paulo Dybala P. Dybala	243	329	22,958	270	127	0.39	67	194	33	11	931	339	31	17,580	858	89
3	Matteo Politano M. Politano	235	338	20,311	240	53	0.16	43	96	6	1	619	184	22	13,136	814	30
4	Lorenzo Insigne L. Insigne	229	263	19,812	237	88	0.33	61	149	27	3	979	343	38	17,553	991	145
5	Fabio Quagliarella F. Quagliarella	214	292	21,152	244	107	0.37	29	136	31	1	865	320	18	8,579	865	257
6	Hakan Çalhanoğlu H. Çalhanoğlu	207	270	20,364	249	55	0.20	59	114	21	3	622	194	20	17,510	461	17
7	Andrea Belotti A. Belotti	193	351	23,810	261	116	0.33	33	149	27	0	817	308	32	10,254	1,180	223
8	Lautaro Martínez L. Martínez	192	246	17,161	197	118	0.48	28	146	11	0	777	297	20	7,518	1,318	96
9	Ciro Immobile C. Immobile	190	285	22,333	260	174	0.61	43	217	52	0	905	410	39	10,012	1,619	231
10	Duván Zapata D. Zapata	183	314	21,479	247	119	0.38	41	160	7	0	773	311	21	10,152	1,601	136
11	Antonio Candreva A. Candreva	178	328	24,068	285	57	0.17	64	121	12	2	671	231	18	17,576	547	146
12	Giacomo Bonaventura G. Bonaventura	176	282	20,362	233	51	0.18	33	84	0	2	536	169	14	14,237	497	34
13	Josip Iličić J. Iličić	172	220	13,517	154	73	0.33	43	116	13	3	598	218	15	11,176	673	43
14	Federico Chiesa F. Chiesa	170	235	16,589	190	48	0.20	34	82	2	0	606	197	19	9,337	1,036	60
15	Dries Mertens D. Mertens	170	262	15,128	161	102	0.39	52	154	9	6	654	256	23	8,702	908	69
16	Edin Džeko E. Džeko	167	276	19,627	212	107	0.39	43	150	3	0	900	356	31	9,090	1,410	114
17	Gonzalo Higuaín G. Higuaín	163	192	14,687	165	108	0.56	23	131	7	0	662	292	13	6,661	517	160
18	Cristiano Ronaldo C. Ronaldo	161	98	8,441	94	81	0.83	15	96	23	1	554	218	17	5,059	647	92
19	Lorenzo Pellegrini L. Pellegrini	161	281	20,105	235	47	0.17	40	87	8	3	534	191	23	13,829	575	38
20	Radja Nainggolan R. Nainggolan	146	219	17,320	198	39	0.18	28	67	0	0	485	126	14	12,667	278	15
21	Papu Gómez P. Gómez	145	211	16,699	196	50	0.24	56	106	4	0	570	222	17	12,860	543	66
22	Luis Alberto L. Alberto	144	242	17,938	213	47	0.19	61	108	4	2	477	152	18	16,191	448	19
23	Gianluca Caprari G. Caprari	144	262	16,236	187	50	0.19	25	75	7	1	447	157	9	9,914	729	87
24	Andrea Pinamonti A. Pinamonti	139	221	15,813	177	53	0.24	8	61	8	0	461	148	9	5,969	812	79
25	Piotr Zieliński P. Zieliński	137	376	23,355	255	44	0.12	51	95	3	0	530	177	14	18,491	491	16