Gianluigi Buffon has made the most career appearances by a player younger than 40 in Serie A, with 629 appearances.

most games by a player before turning 40 years old

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Gianluigi Buffon G. Buffon	629	56,043	627	0	0.00	0	0	0
2	Paolo Maldini P. Maldini	617	53,864	610	29	0.05			0
3	Francesco Totti F. Totti	604	46,882	540	250	0.41	45	295	71
4	Javier Zanetti J. Zanetti	603	52,562	585	12	0.02	6	18	0
5	Gianluca Pagliuca G. Pagliuca	585	52,520	585	0	0.00			0
6	Samir Handanovič S. Handanovič	566	50,577	565	0	0.00	0	0	0
7	Fabio Quagliarella F. Quagliarella	547	37,601	427	181	0.33	33	214	32
8	Roberto Mancini R. Mancini	541	43,935	497	156	0.29			22
9	Pietro Vierchowod P. Vierchowod	533	47,048	529	37	0.07			0
10	Dino Zoff D. Zoff	529	47,584	529	0	0.00			0
11	Silvio Piola S. Piola	528	47,260	528	269	0.51			22
12	Gianni Rivera G. Rivera	526	46,999	525	129	0.25			27
13	Giuseppe Bergomi G. Bergomi	519	45,012	510	23	0.04			0
14	Enrico Albertosi E. Albertosi	519	46,230	518	0	0.00			0
15	Alberto Gilardino A. Gilardino	514	36,821	406	188	0.37	13	201	16
16	Andrea Consigli A. Consigli	510	45,538	510	0	0.00	0	0	0
17	Antonio Candreva A. Candreva	502	36,702	424	85	0.17	79	164	22
18	Ciro Ferrara C. Ferrara	499	41,455	469	27	0.05			0
19	Giovanni Galli G. Galli	496	44,060	489	0	0.00			0
20	Goran Pandev G. Pandev	493	28,227	321	101	0.20	27	128	2
21	Andrea Pirlo A. Pirlo	493	37,349	414	58	0.12	31	89	14
22	Tarcisio Burgnich T. Burgnich	493	44,218	493	6	0.01			0
23	Giuseppe Favalli G. Favalli	486	38,631	455	7	0.01			0
24	Alessandro Del Piero A. Del Piero	478	32,794	378	188	0.39	5	193	50
25	Angelo Peruzzi A. Peruzzi	478	41,414	475	0	0.00			0