Silvio Piola has scored the most career goals by a player 18 or older in Serie A, with 261 goals.

most goals by a player after turning 18 years old

	NAME	G	M	MIN	START	G/M	A	G+A	PK
1	Silvio Piola S. Piola	261	499	44,650	499	0.52			24
2	Francesco Totti F. Totti	249	607	46,683	537	0.41	46	295	71
3	Nils Gunnar Nordahl N. Gunnar Nordahl	225	291	26,100	291	0.77			1
4	José João Altafini J. João Altafini	217	458	39,038	429	0.47			15
5	Giuseppe Meazza G. Meazza	217	367	32,787	367	0.59			13
6	Antonio Di Natale A. Di Natale	209	445	33,917	389	0.47	27	236	33
7	Roberto Baggio R. Baggio	205	452	36,229	417	0.45			68
8	Ciro Immobile C. Immobile	201	354	26,952	310	0.57	49	250	52
9	Kurt Roland Hamrin K. Roland Hamrin	190	400	35,431	395	0.48			14
10	Alessandro Del Piero A. Del Piero	188	478	32,794	378	0.39	5	193	50
11	Giuseppe Signori G. Signori	188	344	27,754	323	0.55			44
12	Alberto Gilardino A. Gilardino	185	497	35,657	394	0.37	13	198	16
13	Gabriel Batistuta G. Batistuta	184	318	27,116	306	0.58			14
14	Fabio Quagliarella F. Quagliarella	182	555	38,035	432	0.33	34	216	32
15	Gian Piero Boniperti G. Piero Boniperti	179	443	39,690	443	0.40			2
16	Amedeo Amadei A. Amadei	175	417	37,530	417	0.42			11
17	Giuseppe Savoldi G. Savoldi	170	405	36,078	404	0.42			45
18	Roberto Boninsegna R. Boninsegna	167	366	32,439	363	0.46			30
19	Guglielmo Gabetto G. Gabetto	164	322	28,935	322	0.51			0
20	Luca Toni L. Toni	157	344	27,181	307	0.46	16	173	17
21	Zlatan Ibrahimovic Z. Ibrahimovic	156	283	21,772	249	0.55	29	185	30
22	Filippo Inzaghi F. Inzaghi	156	370	24,766	271	0.42	0	156	9
23	Luigi Riva L. Riva	156	289	25,764	289	0.54			22
24	Carlo Reguzzoni C. Reguzzoni	156	400	35,865	400	0.39			19
25	Luis Vinicio L. Vinicio	155	348	31,185	348	0.45			15