Since 2009-10, Mohamed Salah has the most goals in the Premier League against Big Six opponents, with 50 goals.

most goals by a player against big six premier league since 2010

	NAME	G	RATING	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Mohamed Salah M. Salah	50		84	6,977	79	0.60	22	72	11
2	Jamie Vardy J. Vardy	45		108	8,408	95	0.42	10	55	8	0	188	92	8	2,258	328	88
3	Sergio Agüero S. Agüero	44		75	5,630	69	0.59	8	52	6
4	Harry Kane H. Kane	39		81	7,007	78	0.48	9	48	11
5	Wayne Rooney W. Rooney	30		72	5,873	65	0.42	6	36	6
6	Sadio Mané S. Mané	29		79	6,196	71	0.37	9	38	0	0	153	76	4	3,686	286	65
7	Marcus Rashford M. Rashford	27		82	5,719	64	0.33	9	36	4	0	130	65	6	2,436	274	39
8	Son Heung-min S. Heung-min	27		88	6,420	76	0.31	9	36	1	0	173	79	5	3,170	289	59
9	Roberto Firmino R. Firmino	25		70	5,255	62	0.36	9	34	1	0	149	69	4	3,313	329	24
10	Christian Benteke C. Benteke	24		83	5,792	64	0.29	9	33	1
11	Erling Haaland E. Haaland	23	7.14	31	2,699	30	0.74	8	31	3	0	104	54	2	737	185	3
12	Kevin De Bruyne K. De Bruyne	23		77	5,896	67	0.30	19	42	2
13	Gylfi Þór Sigurðsson G. Þór Sigurðsson	23		98	7,452	82	0.23	11	34	5
14	Theo Walcott T. Walcott	23		100	6,062	70	0.23	9	32	0
15	Robin van Persie R. van Persie	23		44	3,571	39	0.52	6	29	3
16	Raheem Sterling R. Sterling	22		108	8,028	94	0.20	11	33	0
17	Danny Welbeck D. Welbeck	21		110	6,616	74	0.19	8	29	0
18	Michail Antonio M. Antonio	20		84	6,135	73	0.24	9	29	1	0	136	57	7	2,757	218	35
19	Ollie Watkins O. Watkins	19		62	5,198	59	0.31	7	26	0	0	125	52	3	1,745	282	39
20	Leandro Trossard L. Trossard	19		63	3,928	45	0.30	6	25	0	0	102	38	3	2,085	228	18
21	Darren Bent D. Bent	18		38	2,661	28	0.47	1	19	3
22	Eden Hazard E. Hazard	17		66	5,330	61	0.26	8	25	5
23	Olivier Giroud O. Giroud	17		68	3,466	36	0.25	3	20	0
24	Romelu Lukaku R. Lukaku	17		86	6,366	69	0.20	6	23	1
25	James Maddison J. Maddison	16		70	5,281	62	0.23	11	27	0	1	139	52	4	3,507	170	12