Since 2019-20, Mohamed Salah has scored the most goals in the Premier League against Big Six opponents, with 40 goals.

Interpreted as:

most goals by a player against big six since 2020

	NAME	G	RTG	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Mohamed Salah M. Salah	40		60	5,080	57	0.67	19	59	10	0	188	79	3	2,723	490	29
2	Son Heung-min S. Heung-min	23		53	4,342	51	0.43	8	31	1	0	107	52	4	2,072	196	30
3	Erling Haaland E. Haaland	22	7.12	30	2,609	29	0.73	8	30	3	0	102	52	2	715	179	3
4	Ollie Watkins O. Watkins	19		62	5,198	59	0.31	7	26	0	0	125	52	3	1,745	282	39
5	Marcus Rashford M. Rashford	19		53	3,816	43	0.36	7	26	4	0	96	50	6	1,615	193	30
6	Leandro Trossard L. Trossard	18		62	3,850	44	0.29	5	23	0	0	101	37	3	2,046	221	18
7	Harry Kane H. Kane	17		35	3,105	35	0.49	4	21	5	0	99	43	3	1,253	133	18
8	James Maddison J. Maddison	16		58	4,329	50	0.28	8	24	0	1	113	47	4	2,879	131	11
9	Kevin De Bruyne K. De Bruyne	16		46	3,433	39	0.35	14	30	2	1	119	39	1	2,674	173	8
10	Alexander Isak A. Isak	15	7.19	29	2,307	28	0.52	3	18	0	0	67	28	3	798	137	16
11	Jarrod Bowen J. Bowen	15		66	5,323	61	0.23	9	24	1	0	113	44	5	2,119	233	24
12	Bruno Fernandes B. Fernandes	14		54	4,678	54	0.26	9	23	6	1	112	38	5	3,358	126	16
13	Phil Foden P. Foden	14		49	3,387	38	0.29	5	19	0	0	95	40	3	2,221	200	12
14	Bukayo Saka B. Saka	14		52	4,057	47	0.27	9	23	5	0	91	34	2	2,306	233	19
15	Jamie Vardy J. Vardy	14		53	4,027	45	0.26	2	16	5	0	83	35	5	940	185	37
16	Danny Welbeck D. Welbeck	13		54	3,170	36	0.24	5	18	0	1	99	37	3	1,242	172	11
17	Luis Díaz L. Díaz	12	6.98	26	1,823	23	0.46	4	16	0	0	54	25	0	964	121	12
18	Anthony Gordon A. Gordon	12		49	3,399	40	0.24	7	19	1	0	65	26	0	1,655	126	10
19	Diogo Jota D. Jota	12		45	2,608	30	0.27	5	17	0	0	67	25	1	1,361	185	10
20	James Ward-Prowse J. Ward-Prowse	12		70	5,980	66	0.17	10	22	3	2	69	38	2	4,026	35	0
21	Yoane Wissa Y. Wissa	11	6.78	43	2,235	25	0.26	2	13	0	0	52	19	2	755	104	25
22	Bryan Mbeumo B. Mbeumo	11	6.54	45	3,675	42	0.24	5	16	1	0	95	41	4	1,680	188	17
23	Richarlison	11		51	3,648	40	0.22	4	15	0	0	92	41	1	1,632	207	33
24	Roberto Firmino R. Firmino	11		34	2,267	26	0.32	2	13	0	0	62	31	1	1,335	161	3
25	Sadio Mané S. Mané	11		30	2,469	28	0.37	4	15	0	0	62	30	1	1,451	169	25