Mohamed Salah has scored the most career goals in the Premier League against Man United, with 13 goals.

most goals by a player against manchester united all-time

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Mohamed Salah M. Salah	13	16	1,412	16	0.81	6	19	2	0	59	22	0	837	129	6
2	Alan Shearer A. Shearer	10	25	2,226	25	0.40	4	14	0
3	Erling Haaland E. Haaland	8	6	537	6	1.33	3	11	1	0	23	11	1	143	39	0
4	Sergio Agüero S. Agüero	8	13	952	11	0.62	0	8	0
5	Steven Gerrard S. Gerrard	8	30	2,459	28	0.27	2	10	4
6	Thierry Henry T. Henry	8	14	1,178	13	0.57	4	12	0
7	Robbie Fowler R. Fowler	8	19	1,299	14	0.42	3	11	1
8	Les Ferdinand L. Ferdinand	8	19	1,397	15	0.42	1	9	0
9	Phil Foden P. Foden	7	12	841	10	0.58	0	7	0	0	35	14	2	621	64	2
10	Pascal Groß P. Groß	7	12	900	10	0.58	1	8	1	0	19	12	0	705	35	1
11	Duncan Ferguson D. Ferguson	7	16	1,010	10	0.44	0	7	0
12	Danny Welbeck D. Welbeck	6	16	1,074	12	0.38	1	7	0	1	37	15	1	485	50	4
13	Jimmy Floyd Hasselbaink J. Floyd Hasselbaink	6	13	962	12	0.46	1	7	0
14	Joshua King J. King	5	12	914	11	0.42	1	6	2	0	21	9	0	474	45	3
15	Jamie Vardy J. Vardy	5	17	1,270	15	0.29	2	7	0	0	21	11	1	370	44	12
16	Harry Kane H. Kane	5	18	1,543	17	0.28	3	8	2
17	Gylfi Þór Sigurðsson G. Þór Sigurðsson	5	15	1,086	12	0.33	4	9	1
18	Jermain Defoe J. Defoe	5	26	1,618	18	0.19	0	5	0
19	Mark Viduka M. Viduka	5	9	707	8	0.56	0	5	0
20	Danny Murphy D. Murphy	5	25	1,844	21	0.20	1	6	2
21	Nicolas Anelka N. Anelka	5	19	1,341	14	0.26	2	7	0
22	Matt Le Tissier M. Le Tissier	5	13	926	10	0.38	2	7	0
23	Niall Quinn N. Quinn	5	14	984	11	0.36	2	7	0
24	Brian Deane B. Deane	5	14	1,216	13	0.36	1	6	1
25	Cody Gakpo C. Gakpo	4	6	329	3	0.67	0	4	0	0	16	4	3	167	28	0