Son Heung-min and Harry Kane are tied for the most career combined goals and assists in the Premier League against Southampton, with 18.

most goals and assists by a player vs southampton in history

	NAME	G+A	M	MIN	START	G	G/M	A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Son Heung-min S. Heung-min	18	17	1,117	14	11	0.65	7	1	0	36	22	2	620	76	4
2	Harry Kane H. Kane	18	16	1,329	15	12	0.75	6	1	0	54	23	1	551	57	11
3	Mohamed Salah M. Salah	15	13	1,145	13	11	0.85	4	3	0	53	20	2	585	138	9
4	Alan Shearer A. Shearer	15	22	1,952	22	14	0.64	1	5
5	Andy Cole A. Cole	14	17	1,328	15	11	0.65	3	0
6	Teddy Sheringham T. Sheringham	14	18	1,462	16	9	0.50	5	1
7	Kevin De Bruyne K. De Bruyne	13	14	1,053	12	4	0.29	9	0	0	33	10	1	1,005	49	1
8	Ryan Giggs R. Giggs	13	22	1,680	19	7	0.32	6	0
9	Raheem Sterling R. Sterling	12	21	1,551	17	8	0.38	4	0
10	Dennis Bergkamp D. Bergkamp	12	15	1,082	13	7	0.47	5	0
11	Jamie Vardy J. Vardy	11	19	1,549	18	8	0.42	3	2	0	46	20	0	422	64	17
12	Christian Eriksen C. Eriksen	11	17	1,403	16	4	0.24	7	0
13	Romelu Lukaku R. Lukaku	11	13	1,013	12	9	0.69	2	0
14	Dion Dublin D. Dublin	11	19	1,521	17	9	0.47	2	0
15	Les Ferdinand L. Ferdinand	11	20	1,468	19	7	0.35	4	0
16	Roberto Firmino R. Firmino	10	14	1,048	12	4	0.29	6	0	0	37	14	0	697	62	5
17	Sergio Agüero S. Agüero	10	13	978	12	6	0.46	4	0
18	Thierry Henry T. Henry	10	11	858	9	5	0.45	5	0
19	Michael Owen M. Owen	10	12	811	9	7	0.58	3	0
20	David Beckham D. Beckham	10	15	1,209	13	4	0.27	6	0
21	Paul Scholes P. Scholes	10	16	1,111	12	4	0.25	6	0
22	Robbie Fowler R. Fowler	10	18	1,386	16	9	0.50	1	1
23	James Maddison J. Maddison	9	12	1,024	12	7	0.58	2	0	2	27	11	0	789	29	1
24	Dele Alli D. Alli	9	10	693	8	5	0.50	4	1	0	15	8	0	433	38	4
25	Ayoze Pérez A. Pérez	9	14	813	9	9	0.64	0	0	0	26	17	0	457	37	3