Since 1999-00, Francesco Totti has scored the most goals in Serie A, with 214 goals.

most goals by a player since 2000s

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Francesco Totti F. Totti	214	472	36,699	424	0.45	46	260	67
2	Antonio Di Natale A. Di Natale	209	445	33,917	389	0.47	27	236	33
3	Ciro Immobile C. Immobile	201	354	26,952	310	0.57	49	250	52
4	Alberto Gilardino A. Gilardino	188	514	36,821	406	0.37	13	201	16
5	Fabio Quagliarella F. Quagliarella	182	556	38,059	432	0.33	34	216	32
6	Luca Toni L. Toni	157	344	27,181	307	0.46	16	173	17
7	Zlatan Ibrahimovic Z. Ibrahimovic	156	283	21,772	249	0.55	29	185	30
8	Alessandro Del Piero A. Del Piero	138	347	23,383	269	0.40	5	143	41
9	Paulo Dybala P. Dybala	130	357	24,292	282	0.36	67	197	33
10	Andriy Shevchenko A. Shevchenko	127	226	17,174	195	0.56			24
11	Marco Di Vaio M. Di Vaio	127	303	21,680	240	0.42	10	137	12
12	Domenico Berardi D. Berardi	126	323	25,862	303	0.39	79	205	49
13	Gonzalo Higuaín G. Higuaín	125	224	17,108	193	0.56	29	154	12
14	Duván Zapata D. Zapata	124	332	22,068	253	0.37	43	167	7
15	David Trezeguet D. Trezeguet	123	214	15,665	180	0.57			6
16	Mauro Icardi M. Icardi	121	219	17,197	193	0.55	27	148	19
17	Lautaro Martínez L. Martínez	119	248	17,322	199	0.48	28	147	11	0	785	300	20	7,586	1,329	97
18	Andrea Belotti A. Belotti	116	351	23,810	261	0.33	33	149	27	0	817	308	32	10,254	1,180	223
19	Giampaolo Pazzini G. Pazzini	115	383	22,728	231	0.30	8	123	24
20	Cristiano Lucarelli C. Lucarelli	115	276	21,603	247	0.42	0	115	23
21	Christian Vieri C. Vieri	114	193	13,002	135	0.59			15
22	Antonio Cassano A. Cassano	114	400	28,188	317	0.28	33	147	11
23	Dries Mertens D. Mertens	113	295	17,052	182	0.38	56	169	11
24	Hernán Crespo H. Crespo	113	258	17,140	193	0.44	0	113	12
25	Edinson Cavani E. Cavani	112	213	16,690	183	0.53	12	124	18