Silvio Piola has tallied the most career non-penalty goals in Serie A, with 250 non-penalty goals.

most non-penalty goals by a player ever

	NAME	NPG	G	M	MIN	START	G/M	A	G+A	PK
1	Silvio Piola S. Piola	250	274	537	48,070	537	0.51			24
2	Nils Gunnar Nordahl N. Gunnar Nordahl	224	225	291	26,100	291	0.77			1
3	Giuseppe Meazza G. Meazza	204	217	367	32,787	367	0.59			13
4	José João Altafini J. João Altafini	202	217	458	39,038	429	0.47			15
5	Francesco Totti F. Totti	179	250	618	47,054	540	0.40	46	296	71
6	Gian Piero Boniperti G. Piero Boniperti	177	179	443	39,690	443	0.40			2
7	Antonio Di Natale A. Di Natale	176	209	445	33,917	389	0.47	27	236	33
8	Kurt Roland Hamrin K. Roland Hamrin	176	190	400	35,431	395	0.48			14
9	Alberto Gilardino A. Gilardino	172	188	514	36,821	406	0.37	13	201	16
10	Gabriel Batistuta G. Batistuta	170	184	318	27,116	306	0.58			14
11	Amedeo Amadei A. Amadei	165	176	423	38,070	423	0.42			11
12	Guglielmo Gabetto G. Gabetto	164	164	322	28,935	322	0.51			0
13	Fabio Quagliarella F. Quagliarella	150	182	556	38,059	432	0.33	34	216	32
14	Ciro Immobile C. Immobile	149	201	354	26,952	310	0.57	49	250	52
15	Filippo Inzaghi F. Inzaghi	147	156	370	24,766	271	0.42	0	156	9
16	Giuseppe Signori G. Signori	144	188	344	27,754	323	0.55			44
17	Benito Lorenzi B. Lorenzi	142	142	330	29,430	330	0.43			0
18	Luca Toni L. Toni	140	157	344	27,181	307	0.46	16	173	17
19	Luis Vinicio L. Vinicio	140	155	348	31,185	348	0.45			15
20	Hernán Crespo H. Crespo	139	153	340	23,498	268	0.45	0	153	14
21	Alessandro Del Piero A. Del Piero	138	188	478	32,794	378	0.39	5	193	50
22	Roberto Baggio R. Baggio	137	205	452	36,229	417	0.45			68
23	Roberto Boninsegna R. Boninsegna	137	167	366	32,439	363	0.46			30
24	Enrique Omar Sívori E. Omar Sívori	137	147	278	24,570	278	0.53			10
25	Adriano Bassetto A. Bassetto	137	149	329	29,610	329	0.45			12