Since 1899-00, Gianluigi Buffon has the most wins in Serie A, with 396 wins.

	NAME	W	M	MIN	START	G	G/M	A	G+A	PK
1	Gianluigi Buffon G. Buffon	396	657	58,536	655	0	0.00	0	0	0
2	Paolo Maldini P. Maldini	339	647	56,495	640	29	0.04			0
3	Javier Zanetti J. Zanetti	336	615	53,018	589	12	0.02	6	18	0
4	Francesco Totti F. Totti	316	618	47,054	540	250	0.40	46	296	71
5	Samir Handanovič S. Handanovič	282	566	50,577	565	0	0.00	0	0	0
6	Andrea Pirlo A. Pirlo	276	493	37,349	414	58	0.12	31	89	14
7	Leonardo Bonucci L. Bonucci	269	436	36,567	404	32	0.07	4	36	3
8	Alessandro Del Piero A. Del Piero	268	478	32,794	378	188	0.39	5	193	50
9	Giorgio Chiellini G. Chiellini	264	430	36,291	410	27	0.06	15	42	0
10	Ciro Ferrara C. Ferrara	263	499	41,455	469	27	0.05			0
11	Dino Zoff D. Zoff	259	570	51,274	570	0	0.00			0
12	Daniele De Rossi D. De Rossi	249	459	37,196	428	43	0.09	21	64	4
13	Alessandro Costacurta A. Costacurta	249	458	37,623	419	3	0.01			1
14	Gianni Rivera G. Rivera	245	526	46,999	525	129	0.25			27
15	Tarcisio Burgnich T. Burgnich	245	493	44,218	493	6	0.01			0
16	Giacinto Facchetti G. Facchetti	244	475	42,717	475	59	0.12			0
17	Gian Piero Boniperti G. Piero Boniperti	242	443	39,690	443	179	0.40			2
18	Alessandro Nesta A. Nesta	241	417	35,423	401	8	0.02	0	8	0
19	Franco Baresi F. Baresi	236	470	41,716	470	12	0.03			7
20	Giuseppe Bergomi G. Bergomi	234	519	45,012	510	23	0.04			0
21	Gianluca Pagliuca G. Pagliuca	232	592	53,150	592	0	0.00			0
22	Giuseppe Favalli G. Favalli	231	486	38,631	455	7	0.01			0
23	Roberto Mancini R. Mancini	229	541	43,935	497	156	0.29			22
24	José João Altafini J. João Altafini	229	458	39,038	429	217	0.47			15
25	Pietro Ferraris P. Ferraris	229	469	42,165	469	125	0.27			1