Between the 1999-00 and 2008-09 seasons, Iker Casillas made the most appearances in LaLiga, with 348 appearances.

Most appearances by a player 1999-00 to 2008-09

	NAME	M	MIN	START	G	G/M	PK
1	Iker Casillas I. Casillas	348	31,119	346	0	0.00	0
2	Sergio	340	26,410	303	31	0.09	8
3	Raúl	338	27,952	319	139	0.41	5
4	Pedro Manuel Munitis P. Manuel Munitis	302	21,010	228	34	0.11	0
5	Xavi	301	24,130	272	31	0.10	0
6	Leonardo Franco L. Franco	301	26,705	298	0	0.00	0
7	Raúl Tamudo R. Tamudo	301	23,796	277	119	0.40	30
8	Carles Puyol C. Puyol	299	25,559	286	5	0.02	0
9	Joseba Andoni Etxeberria J. Andoni Etxeberria	298	21,666	250	58	0.19	1
10	José María Gutiérrez J. María Gutiérrez	293	18,274	192	41	0.14	0
11	Ariel Miguel Ibagaza A. Miguel Ibagaza	293	20,861	243	25	0.09	3
12	Capdevila	282	23,091	254	25	0.09	0
13	Joaquín	280	22,340	252	41	0.15	1
14	Samuel Eto'o S. Eto'o	279	23,173	264	162	0.58	18
15	Francisco Javier Yeste F. Javier Yeste	272	18,500	219	48	0.18	5
16	Patxi Punal P. Punal	271	22,103	256	20	0.07	15
17	Rubén Baraja R. Baraja	271	20,332	233	44	0.16	2
18	Aitor López A. López	269	22,295	246	3	0.01	0
19	Santiago Cañizares S. Cañizares	267	23,826	266	0	0.00	0
20	Roberto Carlos R. Carlos	263	23,239	261	33	0.13	2
21	David Albelda D. Albelda	263	20,824	236	5	0.02	0
22	Ismael Urzaiz I. Urzaiz	261	18,589	203	75	0.29	5
23	Lopo	260	22,869	257	13	0.05	0
24	Gonzalo Colsa G. Colsa	259	19,195	221	23	0.09	1
25	Iván Helguera I. Helguera	255	21,087	237	19	0.07	0