Between the 1999-00 and 2008-09 seasons, Frank Lampard made the most appearances in the Premier League, with 348 appearances.

Most appearances by a player 1999-00 to 2008-09

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Frank Lampard F. Lampard	348	30,526	342	97	0.28	71	168	19
2	Jamie Carragher J. Carragher	342	29,653	332	1	0.00	11	12	0
3	Emile Heskey E. Heskey	337	25,641	300	77	0.23	36	113	0
4	David James D. James	333	29,924	333	0	0.00	0	0	0
5	Gareth Barry G. Barry	331	28,476	325	39	0.12	40	79	18
6	Mark Schwarzer M. Schwarzer	329	29,549	329	0	0.00	1	1	0
7	Steven Gerrard S. Gerrard	321	26,440	304	71	0.22	55	126	11
8	Sami Hyypiä S. Hyypiä	318	27,448	310	22	0.07	8	30	0
9	Shay Given S. Given	314	28,042	314	0	0.00	0	0	0
10	Aaron Hughes A. Hughes	309	26,171	294	4	0.01	13	17	0
11	George Boateng G. Boateng	308	25,787	294	11	0.04	11	22	0
12	Rio Ferdinand R. Ferdinand	307	27,204	306	8	0.03	6	14	0
13	Robbie Keane R. Keane	307	22,134	246	115	0.37	35	150	16
14	Kevin Kilbane K. Kilbane	304	23,230	260	14	0.05	17	31	0
15	Phil Neville P. Neville	304	24,367	272	7	0.02	16	23	0
16	Ryan Giggs R. Giggs	303	22,022	247	50	0.17	87	137	0
17	Danny Murphy D. Murphy	302	21,628	235	43	0.14	45	88	13
18	Brad Friedel B. Friedel	301	27,018	301	1	0.00	0	1	0
19	Thomas Sørensen T. Sørensen	301	26,686	300	0	0.00	1	1	0
20	Luke Young L. Young	299	24,908	279	6	0.02	6	12	0
21	Kevin Davies K. Davies	292	23,127	265	57	0.20	37	94	0
22	Jussi Jääskeläinen J. Jääskeläinen	288	25,878	288	0	0.00	2	2	0
23	Paul Scholes P. Scholes	287	22,466	252	66	0.23	33	99	1
24	Hermann Hreiðarsson H. Hreiðarsson	285	24,542	276	11	0.04	15	26	0
25	Richard Dunne R. Dunne	285	24,394	277	7	0.02	4	11	0