Idrissa Gana Guèye has an assist in 12 appearances against Man United in the Premier League in his career.
| NAME | DATE | CLUB | OPP | RTG | MIN | G | A | XG | XA | PK | FK | SH | SOT | WOOD | TCH | TCH-BOX | OFF | FOUL | YC | RC | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | I. Gana Guèye | 8/14/2015 |  Aston Villa | vs |  Man United | 90 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 76 | 0 | 0 | 4 | 1 | 0 | |||
| 2 | | I. Gana Guèye | 4/16/2016 | Aston Villa | @ | Man United | 90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 49 | 0 | 0 | 3 | 0 | 0 | |||
| 3 | | I. Gana Guèye | 12/4/2016 |  Everton | vs | Man United | 90 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 70 | 1 | 0 | 1 | 0 | 0 | |||
| 4 | | I. Gana Guèye | 4/4/2017 | Everton | @ | Man United | 90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 61 | 0 | 0 | 2 | 1 | 0 | |||
| 5 | | I. Gana Guèye | 9/17/2017 | Everton | @ | Man United | 76 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 76 | 0 | 0 | 0 | 0 | 0 | |||
| 6 | | I. Gana Guèye | 10/28/2018 | Everton | @ | Man United | 78 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 60 | 0 | 0 | 3 | 1 | 0 | |||
| 7 | | I. Gana Guèye | 4/21/2019 | Everton | vs | Man United | 76 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 53 | 0 | 0 | 3 | 1 | 0 | |||
| 8 | | I. Gana Guèye | 10/9/2022 | Everton | vs | Man United | 6.6 | 76 | 0 | 0 | 0.00 | 0.01 | 0 | 0 | 0 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | 0 |
| 9 | | I. Gana Guèye | 4/8/2023 | Everton | @ | Man United | 6.1 | 60 | 0 | 0 | 0.01 | 0.01 | 0 | 0 | 1 | 0 | 0 | 35 | 0 | 0 | 0 | 0 | 0 |
| 10 | | I. Gana Guèye | 11/26/2023 | Everton | vs | Man United | 6.7 | 90 | 0 | 0 | 0.35 | 0.05 | 0 | 0 | 3 | 1 | 0 | 77 | 5 | 0 | 3 | 1 | 0 |
| 11 | | I. Gana Guèye | 12/1/2024 | Everton | @ | Man United | 6.2 | 67 | 0 | 0 | 0.00 | 0.01 | 0 | 0 | 0 | 0 | 0 | 53 | 0 | 0 | 3 | 1 | 0 |
| 12 | | I. Gana Guèye | 2/22/2025 | Everton | vs | Man United | 7.0 | 90 | 0 | 0 | 0.02 | 0.01 | 0 | 0 | 1 | 1 | 0 | 55 | 1 | 0 | 1 | 1 | 0 |
| Total | 973 | 0 | 1 | 0 | 0 | 8 | 3 | 0 | 699 | 7 | 0 | 23 | 7 | 0 |
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| 1 |  Arsenal | 8 | 2 | 1 | 15 | 26 |
| 2 |  Man City | 7 | 1 | 3 | 15 | 22 |
| 3 |  Chelsea | 6 | 2 | 3 | 10 | 20 |
| 4 |  Sunderland | 5 | 4 | 2 | 4 | 19 |
| 5 |  Tottenham | 5 | 3 | 3 | 9 | 18 |
| 6 |  Aston Villa | 5 | 3 | 3 | 3 | 18 |
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