Mohamed Salah has tallied the most career goals by a Liverpool player in the Premier League against Big Six opponents, with 49 goals.

most goals by a player vs the big 6 all-time for liverpool

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Mohamed Salah M. Salah	49	80	6,786	77	0.61	22	71	11	0	256	111	4	3,613	636	40
2	Robbie Fowler R. Fowler	29	57	4,274	46	0.51	6	35	3
3	Roberto Firmino R. Firmino	25	70	5,255	62	0.36	9	34	1	0	149	69	4	3,313	329	24
4	Steven Gerrard S. Gerrard	22	129	10,736	123	0.17	23	45	8
5	Sadio Mané S. Mané	20	57	4,580	53	0.35	5	25	0	0	111	55	4	2,691	286	44
6	Michael Owen M. Owen	20	50	3,703	42	0.40	5	25	2
7	Fernando Torres F. Torres	16	26	2,015	23	0.62	2	18	0
8	Dirk Kuyt D. Kuyt	13	57	4,705	54	0.23	8	21	2
9	Ian Rush I. Rush	13	33	2,773	30	0.39	2	15	0
10	Luis Díaz L. Díaz	12	26	1,823	23	0.46	4	16	0	0	54	25	0	964	121	12
11	Philippe Coutinho P. Coutinho	12	40	3,091	37	0.30	4	16	0
12	Diogo Jota D. Jota	11	34	1,820	21	0.32	4	15	0	0	44	20	1	880	118	8
13	Luis Suárez L. Suárez	11	32	2,717	30	0.34	5	16	0
14	Patrik Berger P. Berger	11	34	2,176	23	0.32	5	16	0
15	Steve McManaman S. McManaman	11	56	4,893	54	0.20	11	22	0
16	Cody Gakpo C. Gakpo	10	29	1,697	20	0.34	2	12	0	0	49	17	3	813	104	9
17	Martin Škrtel M. Škrtel	9	65	5,643	63	0.14	1	10	0
18	Daniel Sturridge D. Sturridge	8	32	1,744	18	0.25	4	12	0
19	Jordan Henderson J. Henderson	8	97	7,317	83	0.08	10	18	1
20	Jamie Redknapp J. Redknapp	8	52	4,249	47	0.15	6	14	2
21	John Barnes J. Barnes	7	36	3,032	36	0.19	5	12	1
22	Georginio Wijnaldum G. Wijnaldum	5	48	3,717	42	0.10	2	7	0	0	54	24	0	2,508	76	2
23	James Milner J. Milner	5	61	3,658	40	0.08	2	7	3	0	34	10	0	3,215	45	2
24	Raheem Sterling R. Sterling	5	25	2,014	23	0.20	3	8	0
25	Harry Kewell H. Kewell	5	25	2,025	22	0.20	0	5	0