Johan Santana struck out the most hitters in 2005, with 238 strikeouts.

	NAME	SO	SEASON	TM	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	238	2005	MIN	33	16	7	.696	33	2.87	3	2	0	231.2	180	74	77	22	45	1	0	1	910	8	9.25	1.75	5.29	0.85	26.2	4.9	0.97	.262	2.99	67	2.79	66	6.99	37
2	Jake Peavy J. Peavy	216	2005	SDP	30	13	7	.650	30	2.88	3	3	0	203.0	162	65	70	18	50	7	0	3	812	3	9.58	2.22	4.32	0.80	26.6	6.2	1.04	.276	3.10	74	2.88	71	7.18	27.9
3	Chris Carpenter C. Carpenter	213	2005	STL	33	21	5	.808	33	2.83	7	4	0	241.2	204	76	82	18	51	3	0	0	953	5	7.93	1.90	4.18	0.67	22.4	5.4	1.06	.278	3.05	68	2.89	69	7.60	34.8
4	Randy Johnson R. Johnson	211	2005	NYY	34	17	8	.680	34	3.79	4	0	0	225.2	207	95	102	32	47	12	0	2	920	3	8.42	1.87	4.49	1.28	22.9	5.1	1.13	.283	4.07	88	3.77	87	8.26	13.8
5	Doug Davis D. Davis	208	2005	MIL	35	11	11	.500	35	3.84	2	1	0	222.2	196	95	103	26	93	4	0	5	946	3	8.41	3.76	2.24	1.05	22.0	9.8	1.30	.276	4.16	90	3.97	92	7.92	8
6	Pedro Martinez P. Martinez	208	2005	NYM	31	15	8	.652	31	2.82	4	1	0	217.0	159	68	69	19	47	4	0	3	843	4	8.63	1.95	4.43	0.79	24.7	5.6	0.95	.248	2.86	68	2.94	71	6.59	30
7	Brett Myers B. Myers	208	2005	PHI	34	13	8	.619	34	3.72	2	0	0	215.1	193	89	94	31	68	11	0	2	905	4	8.69	2.84	3.06	1.30	23.0	7.5	1.21	.276	3.93	86	4.05	93	8.07	7.8
8	Carlos Zambrano C. Zambrano	202	2005	CHC	33	14	6	.700	33	3.26	2	0	0	223.1	170	81	88	21	86	8	0	3	909	7	8.14	3.47	2.35	0.85	22.2	9.5	1.15	.252	3.55	75	3.69	85	6.85	15.9
9	John Lackey J. Lackey	199	2005	LAA	33	14	5	.737	33	3.44	1	0	0	209.0	208	80	85	13	71	11	0	3	892	18	8.57	3.06	2.80	0.56	22.3	8.0	1.33	.326	3.66	81	3.09	73	8.96	26.9
10	A.J. Burnett	198	2005	FLA	32	12	12	.500	32	3.44	4	2	0	209.0	184	80	97	12	79	7	0	1	873	12	8.53	3.40	2.51	0.52	22.7	9.0	1.26	.298	4.18	84	3.10	74	7.92	25.1
11	Javier Vazquez J. Vazquez	192	2005	ARI	33	11	15	.423	33	4.42	3	1	0	215.2	223	106	112	35	46	5	0	4	904	7	8.01	1.92	4.17	1.46	21.2	5.1	1.25	.300	4.67	100	4.05	93	9.31	7.8
12	Mark Prior M. Prior	188	2005	CHC	27	11	7	.611	27	3.67	1	0	0	166.2	143	68	73	25	59	4	0	2	701	4	10.15	3.19	3.19	1.35	26.8	8.4	1.21	.278	3.94	84	3.84	89	7.72	9.1
13	Roger Clemens R. Clemens	185	2005	HOU	32	13	8	.619	32	1.87	1	0	0	211.1	151	44	51	11	62	3	0	5	838	3	7.88	2.64	2.98	0.47	22.1	7.4	1.01	.243	2.17	44	2.86	67	6.43	33.4
14	John Patterson J. Patterson	185	2005	WSH	31	9	7	.563	31	3.13	2	1	0	198.1	172	69	71	19	65	5	0	11	817	9	8.39	2.95	2.85	0.86	22.6	8.0	1.19	.282	3.22	77	3.45	84	7.81	15
15	Roy Oswalt R. Oswalt	184	2005	HOU	35	20	12	.625	35	2.94	4	1	0	241.2	243	79	85	18	48	8	0	3	1,002	5	6.85	1.79	3.83	0.67	18.4	4.8	1.20	.302	3.17	70	3.15	73	9.05	30.4
16	Chris Capuano C. Capuano	176	2005	MIL	35	18	12	.600	35	3.99	0	0	0	219.0	212	97	105	31	91	12	0	6	949	3	7.23	3.74	1.93	1.27	18.5	9.6	1.38	.283	4.32	94	4.65	108	8.71	-8.7
17	Scott Kazmir S. Kazmir	174	2005	TBD	32	10	9	.526	32	3.77	0	0	0	186.0	172	78	90	12	100	10	0	3	818	7	8.42	4.84	1.74	0.58	21.3	12.2	1.46	.307	4.35	89	3.75	87	8.32	11.7
18	Esteban Loaiza E. Loaiza	173	2005	WSH	34	12	10	.545	34	3.77	0	0	0	217.0	227	91	93	18	55	5	0	3	912	6	7.18	2.28	3.15	0.75	19.0	6.0	1.30	.316	3.86	93	3.32	81	9.41	19.5
19	Noah Lowry N. Lowry	172	2005	SFG	33	13	13	.500	33	3.78	0	0	0	204.2	193	86	92	21	76	7	0	1	875	2	7.56	3.34	2.26	0.92	19.7	8.7	1.31	.287	4.05	90	3.88	94	8.49	5.4
20	Brandon Webb B. Webb	172	2005	ARI	33	14	12	.538	33	3.54	1	0	0	229.0	229	90	98	21	59	2	0	4	943	14	6.76	2.32	2.92	0.83	18.2	6.3	1.26	.302	3.85	80	3.50	80	9.00	21.9
21	Andy Pettitte A. Pettitte	171	2005	HOU	33	17	9	.654	33	2.39	0	0	0	222.1	188	59	66	17	41	3	0	0	875	2	6.92	1.66	4.17	0.69	19.5	4.7	1.03	.266	2.67	57	3.06	71	7.61	30.2
22	Barry Zito B. Zito	171	2005	OAK	35	14	13	.519	35	3.86	0	0	0	228.1	185	98	106	26	89	13	0	0	953	4	6.74	3.51	1.92	1.02	17.9	9.3	1.20	.243	4.18	92	4.33	100	7.29	-0.3
23	Dontrelle Willis D. Willis	170	2005	FLA	34	22	10	.688	34	2.63	7	5	0	236.1	213	69	79	11	55	8	0	3	960	2	6.47	2.09	3.09	0.42	17.7	5.7	1.13	.282	3.01	64	2.98	71	8.11	31.6
24	John Smoltz J. Smoltz	169	2005	ATL	33	14	7	.667	33	3.06	3	1	0	229.2	210	78	83	18	53	1	0	7	931	2	6.62	2.08	3.19	0.71	18.2	5.7	1.15	.278	3.25	73	3.26	78	8.23	24.2
25	Josh Beckett J. Beckett	166	2005	FLA	29	15	8	.652	29	3.38	2	1	0	178.2	153	67	75	14	58	7	0	2	728	5	8.36	2.92	2.86	0.71	22.8	8.0	1.18	.288	3.78	82	3.26	78	7.71	18.1