The Houston Astros have a record of 383-337 against the Cubs all-time.

	OPP	REC	W%	G	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	383-337	.532	720	383	337	24,521	3,147	6,331	1,156	199	596	2,949	2,350	188	4,362	486	236	27,616	9,673	1,951	364	193	288	516	.258	.325	.394	.720
2	Phillies	283-298	.487	581	283	298	19,549	2,325	4,957	908	150	384	2,177	1,843	175	3,529	414	186	21,965	7,317	1,442	244	154	204	455	.254	.321	.374	.695
3	Mets	322-263	.550	586	322	263	19,865	2,451	5,002	846	157	425	2,274	1,880	160	3,492	460	191	22,341	7,437	1,428	268	168	200	415	.252	.319	.374	.693
4	Cardinals	336-384	.467	722	336	384	24,513	2,977	6,331	1,187	168	513	2,799	2,285	191	4,082	420	243	27,511	9,393	1,868	339	183	255	575	.258	.324	.383	.707
5	Braves	330-386	.461	717	330	386	24,515	2,835	6,242	1,021	152	466	2,653	2,215	135	4,063	641	236	27,370	8,965	1,639	308	197	221	503	.255	.317	.366	.683
6	Dodgers	331-397	.455	728	331	397	24,694	2,732	5,955	988	164	444	2,544	2,158	163	4,487	552	232	27,526	8,603	1,596	343	168	227	481	.241	.304	.348	.653
7	Giants	354-387	.478	741	354	387	25,042	2,956	6,280	1,055	170	503	2,755	2,342	175	4,269	578	270	28,123	9,184	1,728	371	193	305	495	.251	.317	.367	.684
8	Reds	403-453	.471	857	403	453	28,973	3,544	7,331	1,397	184	690	3,350	2,787	231	5,115	580	286	32,578	11,166	2,271	361	226	318	605	.253	.321	.385	.707
9	Pirates	346-369	.484	715	346	369	24,236	2,990	6,250	1,144	174	488	2,811	2,369	204	4,058	467	226	27,344	9,206	1,806	319	216	252	591	.258	.326	.380	.706
10	Padres	321-294	.522	615	321	294	20,590	2,465	5,067	886	145	428	2,283	2,048	127	3,447	554	210	23,259	7,527	1,459	318	176	246	419	.246	.316	.366	.681
11	Nationals	249-211	.541	460	249	211	15,646	1,986	4,021	705	112	331	1,869	1,538	142	2,719	440	201	17,683	5,943	1,148	222	135	147	307	.257	.326	.380	.706
12	Marlins	88-81	.521	169	88	81	5,759	770	1,488	315	39	160	729	622	61	1,158	112	48	6,551	2,361	514	74	35	59	136	.258	.335	.410	.745
13	Rockies	106-85	.555	191	106	85	6,632	1,077	1,897	366	55	225	1,018	640	112	1,210	156	56	7,519	3,048	646	82	53	56	162	.286	.356	.460	.816
14	Twins	48-44	.522	92	48	44	3,175	485	866	176	2	127	461	296	35	700	51	19	3,555	1,427	305	17	32	3	83	.273	.338	.449	.788
15	Royals	58-49	.542	107	58	49	3,646	517	965	186	17	125	493	393	38	778	41	19	4,136	1,560	328	24	35	15	92	.265	.339	.428	.767
16	Guardians	46-45	.505	91	46	45	3,085	384	748	158	11	102	367	315	27	810	59	29	3,471	1,234	271	21	23	14	66	.242	.316	.400	.716
17	White Sox	51-45	.531	96	51	45	3,255	461	860	163	9	123	438	332	36	762	70	28	3,662	1,410	295	13	26	19	79	.264	.337	.433	.770
18	Brewers	134-121	.525	255	134	121	8,640	1,187	2,251	424	51	288	1,142	928	79	1,809	176	56	9,842	3,641	763	124	71	67	199	.261	.335	.421	.757
19	Tigers	52-39	.571	91	52	39	3,057	410	782	133	20	103	389	290	34	659	43	27	3,424	1,264	256	14	29	11	77	.256	.324	.413	.738
20	Diamondbacks	69-80	.463	149	69	80	5,150	714	1,363	289	27	174	676	430	89	1,080	105	46	5,750	2,228	490	43	38	29	121	.265	.330	.433	.762
21	Rangers	141-142	.498	283	141	142	9,611	1,317	2,430	481	33	355	1,257	970	113	2,066	145	54	10,802	4,042	869	36	72	34	224	.253	.326	.421	.747
22	Athletics	115-98	.540	213	115	98	7,249	996	1,845	368	30	277	952	643	71	1,552	113	45	8,059	3,104	675	32	64	28	170	.255	.319	.428	.747
23	Mariners	128-91	.584	219	128	91	7,498	1,019	1,941	437	31	258	971	675	66	1,696	128	44	8,319	3,214	726	24	56	43	167	.259	.323	.429	.752
24	Orioles	47-34	.580	81	47	34	2,748	421	720	146	9	116	406	264	43	617	43	17	3,095	1,232	271	13	27	8	64	.262	.333	.448	.782
25	Rays	40-44	.476	84	40	44	2,754	300	614	122	8	94	290	230	18	674	40	16	3,028	1,034	224	8	18	13	54	.223	.285	.375	.661