The Houston Astros had their highest run differential in a game versus the Orioles on August 10, 2019, with a differential of 21 runs.

Interpreted as:

astros highest run differential in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
2	Astros	20	9/8/2019	HOU	vs	SEA	W 21-1	47	21	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
3	Astros	18	7/9/2017	HOU	@	TOR	W 19-1	45	19	17	4	0	5	16	8	1	7	1	0	54	36	9	0	0	0	1	.378	.481	.800	1.281
4	Astros	17	9/20/2007	HOU	@	STL	W 18-1	48	18	23	5	0	1	16	6	2	3	0	0	57	31	6	1	0	1	2	.479	.554	.646	1.199
5	Astros	16	8/18/2022	HOU	@	CWS	W 21-5	51	21	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
6	Astros	16	10/2/2015	HOU	@	ARI	W 21-5	46	21	19	4	1	4	18	8	0	8	1	0	57	37	9	1	2	1	0	.413	.482	.804	1.286
7	Astros	16	4/29/1974	HOU	vs	CHC	W 18-2	43	18	20	1	1	2	14	6	0	6	4	0	51	29	4	0	2	0	0	.465	.510	.674	1.184
8	Astros	16	6/7/1967	HOU	@	STL	W 17-1	48	17	23	4	1	0	17	5	0	5	1	0	56	29	5	2	1	0	0	.479	.519	.604	1.123
9	Astros	15	9/9/2019	HOU	vs	OAK	W 15-0	39	15	17	0	1	7	14	2	0	2	0	0	41	40	8	0	0	0	3	.436	.463	1.026	1.489
10	Astros	15	6/30/1998	HOU	vs	CWS	W 17-2	39	17	18	3	0	4	17	3	0	7	0	0	43	33	7	0	1	0	2	.462	.488	.846	1.335
11	Astros	15	4/26/1998	HOU	@	MON	W 15-0	47	15	18	5	0	2	14	3	0	7	2	1	50	29	7	0	0	0	0	.383	.420	.617	1.037
12	Astros	15	8/20/1985	HOU	vs	STL	W 17-2	42	17	19	4	2	2	14	5	0	4	0	0	47	33	8	0	0	1	1	.452	.511	.786	1.296
13	Astros	14	6/29/2023	HOU	@	STL	W 14-0	44	14	18	4	0	2	14	8	0	8	0	0	52	28	6	0	0	0	0	.409	.500	.636	1.136
14	Astros	14	9/13/2021	HOU	@	TEX	W 15-1	42	15	16	3	0	5	15	5	1	8	0	0	48	34	8	0	0	0	1	.381	.458	.810	1.268
15	Astros	14	8/21/2021	HOU	vs	SEA	W 15-1	38	15	15	5	2	2	14	3	0	5	0	0	42	30	9	0	1	0	0	.395	.429	.789	1.218
16	Astros	14	4/24/2021	HOU	vs	LAA	W 16-2	42	16	18	7	1	3	14	5	1	7	0	0	48	36	11	0	0	1	2	.429	.500	.857	1.357
17	Astros	14	8/27/2019	HOU	vs	TBR	W 15-1	40	15	18	4	1	3	14	3	2	7	0	1	46	33	8	0	1	0	0	.450	.500	.825	1.325
18	Astros	14	8/4/2018	HOU	@	LAD	W 14-0	38	14	13	6	0	3	14	5	1	7	1	0	46	28	9	1	1	2	0	.342	.422	.737	1.159
19	Astros	14	5/7/2018	HOU	@	OAK	W 16-2	45	16	20	5	0	3	14	6	0	4	0	0	51	34	8	0	0	0	2	.444	.510	.756	1.265
20	Astros	14	8/25/2015	HOU	@	NYY	W 15-1	43	15	15	4	1	3	14	8	0	4	0	0	51	30	8	0	0	0	0	.349	.451	.698	1.149
21	Astros	14	8/3/2010	HOU	@	STL	W 18-4	45	18	22	4	1	0	17	5	0	5	0	0	53	28	5	1	2	0	1	.489	.519	.622	1.141
22	Astros	14	8/26/2003	HOU	vs	LAD	W 18-4	40	18	17	5	1	2	17	9	0	8	2	0	49	30	8	0	0	0	1	.425	.531	.750	1.281
23	Astros	14	5/13/2002	HOU	vs	PHI	W 17-3	45	17	20	8	1	0	15	4	0	7	0	1	49	30	9	0	0	0	0	.444	.490	.667	1.156
24	Astros	14	8/14/2000	HOU	vs	PIT	W 16-2	40	16	19	5	0	3	16	6	1	6	0	1	49	33	8	1	1	0	0	.475	.542	.825	1.367
25	Astros	14	7/7/1971	HOU	@	SFG	W 18-4	45	18	17	6	0	0	18	4	1	5	2	0	51	23	6	0	1	0	0	.378	.431	.511	.942