Don Wilson had a record of 104-92 with an ERA of 3.15, 1,283 strikeouts and 2 saves in 266 appearances for the Astros in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Wilson | 1966 |  HOU | 1 | 1 | 0 | 1.000 | 0 | 3.00 | 7 | 0 | 0 | 0 | 6.0 | 5 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 22 | 0 | 10.50 | 1.50 | 7.00 | 1.50 | 31.8 | 4.5 | 1.00 | .308 | 3.00 | 86 | 2.89 | 85 | 7.50 | 0.3 |
| 2 | | D. Wilson | 1967 | HOU | 31 | 10 | 9 | .526 | 28 | 2.79 | 159 | 7 | 3 | 0 | 184.0 | 141 | 57 | 67 | 10 | 69 | 7 | 0 | 2 | 757 | 10 | 7.78 | 3.38 | 2.30 | 0.49 | 21.0 | 9.1 | 1.14 | .256 | 3.28 | 85 | 2.76 | 87 | 6.90 | 8.2 |
| 3 | | D. Wilson | 1968 | HOU | 33 | 13 | 16 | .448 | 30 | 3.28 | 175 | 9 | 3 | 0 | 208.2 | 187 | 76 | 85 | 9 | 70 | 4 | 3 | 5 | 884 | 9 | 7.55 | 3.02 | 2.50 | 0.39 | 19.8 | 7.9 | 1.23 | .284 | 3.67 | 112 | 2.33 | 84 | 8.07 | 10.1 |
| 4 | | D. Wilson | 1969 | HOU | 34 | 16 | 12 | .571 | 34 | 4.00 | 235 | 13 | 1 | 0 | 225.0 | 210 | 100 | 119 | 16 | 97 | 9 | 0 | 8 | 979 | 16 | 9.40 | 3.88 | 2.42 | 0.64 | 24.0 | 9.9 | 1.36 | .312 | 4.76 | 115 | 2.75 | 82 | 8.40 | 14.8 |
| 5 | | D. Wilson | 1970 | HOU | 29 | 11 | 6 | .647 | 27 | 3.91 | 94 | 3 | 0 | 0 | 184.1 | 188 | 80 | 92 | 15 | 66 | 7 | 1 | 4 | 806 | 15 | 4.59 | 3.22 | 1.42 | 0.73 | 11.7 | 8.2 | 1.38 | .277 | 4.49 | 98 | 3.86 | 102 | 9.18 | -1.3 |
| 6 | | D. Wilson | 1971 | HOU | 35 | 16 | 10 | .615 | 34 | 2.45 | 180 | 18 | 3 | 0 | 268.0 | 195 | 73 | 80 | 15 | 79 | 7 | 0 | 3 | 1,067 | 5 | 6.04 | 2.65 | 2.28 | 0.50 | 16.9 | 7.4 | 1.02 | .229 | 2.69 | 72 | 2.79 | 84 | 6.55 | 15.3 |
| 7 | | D. Wilson | 1972 | HOU | 33 | 15 | 10 | .600 | 33 | 2.68 | 172 | 13 | 3 | 0 | 228.1 | 196 | 68 | 79 | 16 | 66 | 2 | 0 | 2 | 927 | 11 | 6.78 | 2.60 | 2.61 | 0.63 | 18.6 | 7.1 | 1.15 | .268 | 3.11 | 80 | 2.69 | 83 | 7.73 | 13.6 |
| 8 | | D. Wilson | 1973 | HOU | 37 | 11 | 16 | .407 | 32 | 3.20 | 149 | 10 | 3 | 2 | 239.1 | 187 | 85 | 94 | 21 | 92 | 7 | 4 | 6 | 988 | 7 | 5.60 | 3.46 | 1.62 | 0.79 | 15.1 | 9.3 | 1.17 | .231 | 3.53 | 90 | 3.69 | 104 | 7.03 | -3.9 |
| 9 | | D. Wilson | 1974 | HOU | 33 | 11 | 13 | .458 | 27 | 3.08 | 112 | 5 | 4 | 0 | 204.2 | 170 | 70 | 80 | 16 | 100 | 4 | 2 | 2 | 875 | 4 | 4.93 | 4.40 | 1.12 | 0.70 | 12.8 | 11.4 | 1.32 | .240 | 3.52 | 89 | 4.01 | 116 | 7.48 | -13.4 |
| Total | 266 | 104 | 92 | .531 | 245 | 3.15 | 1,283 | 78 | 20 | 2 | 1748.1 | 1,479 | 611 | 698 | 119 | 640 | 47 | 10 | 32 | 7,305 | 77 | 6.60 | 3.29 | 2.00 | 0.61 | 17.6 | 8.8 | 1.21 | .261 | 3.59 | 92 | 3.09 | 92 | 7.61 | 43.7 |
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