Between the 2008 and 2023 seasons, the Los Angeles Dodgers had the highest run differential by a team, with a differential of 2,198 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	2,198	2,490	.586	1,458	1,032	84,362	11,579	21,592	4,326	404	2,834	11,023	8,740	966	19,282	1,390	493	95,480	35,228	7,564	745	667	671	1,824	.256	.330	.418	.748
2	Yankees	1,614	2,490	.570	1,419	1,071	84,495	12,119	21,544	4,018	313	3,381	11,588	8,858	946	19,265	1,434	427	95,321	36,331	7,712	344	678	397	1,941	.255	.330	.430	.760
3	Rays	1,206	2,491	.548	1,366	1,125	84,282	11,262	21,049	4,286	481	2,817	10,733	8,552	1,041	20,732	1,781	662	94,878	34,748	7,584	333	670	386	1,691	.250	.324	.412	.736
4	Cardinals	1,114	2,488	.547	1,360	1,128	84,338	11,321	21,764	4,310	367	2,663	10,791	8,174	1,026	18,569	1,145	476	94,942	34,797	7,340	749	655	618	1,956	.258	.329	.413	.741
5	Red Sox	1,106	2,490	.536	1,334	1,156	86,352	12,447	23,018	5,160	376	2,892	11,830	8,443	884	19,121	1,387	427	96,678	37,606	8,428	287	712	549	1,992	.267	.336	.435	.771
6	Braves	843	2,488	.534	1,329	1,159	84,671	11,270	21,637	4,338	353	2,747	10,766	8,312	823	19,630	1,217	465	95,154	34,922	7,438	772	576	639	1,866	.256	.326	.412	.738
7	Guardians	435	2,488	.516	1,284	1,204	84,488	11,185	21,436	4,511	377	2,553	10,638	8,200	957	18,681	1,622	485	94,833	34,360	7,441	476	712	439	1,837	.254	.324	.407	.731
8	Astros	430	2,489	.510	1,269	1,220	84,490	11,175	21,532	4,341	352	2,854	10,667	7,695	858	18,948	1,506	577	94,199	35,139	7,547	514	642	384	1,950	.255	.321	.416	.737
9	Blue Jays	407	2,490	.506	1,259	1,231	84,899	11,608	21,547	4,479	295	3,215	11,102	8,051	791	18,851	1,228	441	94,718	36,261	7,989	352	625	308	1,959	.254	.322	.427	.749
10	Cubs	295	2,489	.506	1,259	1,229	84,280	11,070	21,058	4,273	442	2,763	10,533	8,270	1,100	20,860	1,184	521	94,884	34,504	7,478	659	575	544	1,830	.250	.323	.409	.732
11	Brewers	251	2,491	.520	1,296	1,195	84,037	11,091	20,972	4,176	418	2,940	10,602	8,182	1,033	20,710	1,693	537	94,524	34,804	7,534	697	575	516	1,857	.250	.322	.414	.736
12	Giants	102	2,490	.513	1,277	1,213	84,729	10,400	21,334	4,278	515	2,214	9,889	7,489	804	19,129	1,145	471	94,391	33,284	7,007	680	689	569	1,902	.252	.316	.393	.709
13	Angels	44	2,490	.509	1,268	1,222	84,585	11,226	21,494	4,098	390	2,796	10,697	7,599	887	18,659	1,477	567	94,178	34,760	7,284	447	660	506	1,945	.254	.320	.411	.731
14	Rangers	-4	2,491	.501	1,249	1,242	85,056	11,801	21,926	4,283	397	2,978	11,217	7,637	927	19,507	1,721	598	94,780	35,937	7,658	467	693	394	1,727	.258	.323	.423	.746
15	Athletics	-14	2,489	.491	1,221	1,268	84,160	10,836	20,520	4,256	384	2,621	10,294	8,170	894	19,328	1,383	423	94,198	33,407	7,261	327	647	298	1,875	.244	.315	.397	.712
16	Mets	-16	2,490	.494	1,231	1,259	84,278	10,709	21,073	4,161	426	2,576	10,244	8,092	1,032	19,139	1,346	471	94,720	33,814	7,163	706	612	609	1,841	.250	.321	.401	.722
17	Nationals	-53	2,488	.488	1,214	1,274	84,245	10,952	21,467	4,213	399	2,635	10,432	8,046	918	19,311	1,476	500	94,627	34,383	7,247	777	641	552	1,875	.255	.324	.408	.732
18	Phillies	-62	2,490	.506	1,259	1,231	84,695	10,977	21,129	4,168	486	2,751	10,488	7,847	924	19,731	1,505	403	94,722	34,522	7,405	683	573	608	1,692	.249	.318	.408	.726
19	Twins	-222	2,492	.487	1,214	1,278	85,230	11,458	21,794	4,388	444	2,703	10,916	8,122	816	19,477	1,156	450	95,245	35,179	7,535	402	675	417	1,848	.256	.324	.413	.737
20	Diamondbacks	-345	2,490	.474	1,180	1,310	84,763	11,104	21,199	4,467	618	2,598	10,556	8,154	780	20,465	1,494	506	95,014	34,696	7,683	677	640	578	1,717	.250	.319	.409	.729
21	Reds	-533	2,490	.476	1,185	1,305	84,157	10,830	20,966	4,073	389	2,789	10,342	7,993	1,051	20,054	1,510	607	94,651	34,184	7,251	850	600	530	1,729	.249	.320	.406	.726
22	White Sox	-630	2,490	.474	1,181	1,309	84,790	10,754	21,562	4,018	357	2,724	10,298	6,898	1,000	19,430	1,318	569	93,718	34,466	7,099	444	586	317	1,948	.254	.316	.406	.722
23	Mariners	-712	2,490	.482	1,199	1,291	84,368	10,265	20,577	3,918	316	2,669	9,799	7,498	900	20,021	1,418	533	93,758	33,134	6,903	409	583	383	1,727	.244	.310	.393	.703
24	Padres	-755	2,490	.467	1,164	1,326	83,411	10,087	20,079	3,896	435	2,422	9,597	7,944	803	20,656	1,588	540	93,511	32,111	6,753	737	616	502	1,717	.241	.311	.385	.696
25	Tigers	-780	2,486	.477	1,186	1,300	85,083	10,931	22,055	4,239	525	2,547	10,474	7,459	745	19,578	1,025	440	94,319	34,985	7,311	382	650	435	1,977	.259	.322	.411	.733