Since 1990, the New York Yankees have the highest run differential by a team, with a differential of 3,681 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	3,681	5,596	.570	3,190	2,403	191,784	28,442	50,858	9,585	750	7,131	27,166	20,869	2,046	38,781	3,375	1,231	217,276	83,336	17,466	894	1,683	1,226	4,608	.265	.341	.435	.775
2	Braves	3,030	5,594	.558	3,119	2,474	190,684	26,044	49,565	9,663	902	6,275	24,805	18,758	1,697	40,083	3,067	1,313	214,664	79,857	16,840	2,076	1,449	1,517	4,246	.260	.329	.419	.748
3	Dodgers	2,939	5,599	.553	3,094	2,505	190,213	25,472	49,073	9,063	992	5,906	24,190	18,911	1,819	39,313	3,662	1,441	214,543	77,838	15,961	2,106	1,494	1,541	4,060	.258	.329	.409	.738
4	Red Sox	2,344	5,600	.538	3,012	2,588	194,159	28,168	52,424	11,455	949	6,267	26,807	19,772	1,984	38,974	2,840	1,139	218,539	84,578	18,671	937	1,687	1,433	4,583	.270	.341	.436	.777
5	Cardinals	1,628	5,596	.534	2,988	2,606	190,215	25,771	49,719	9,655	947	5,710	24,480	18,731	2,004	38,572	3,464	1,501	214,563	78,398	16,312	2,041	1,572	1,619	4,229	.261	.332	.412	.744
6	Astros	1,429	5,598	.518	2,898	2,699	190,510	25,704	49,362	9,826	947	5,890	24,408	18,575	2,111	39,492	3,828	1,554	214,640	78,752	16,663	1,888	1,556	1,405	4,314	.259	.329	.413	.743
7	Guardians	1,377	5,591	.521	2,915	2,676	191,418	26,830	50,452	10,175	908	6,060	25,512	18,916	1,974	38,167	3,786	1,434	215,282	80,623	17,143	1,257	1,717	1,176	4,373	.264	.333	.421	.755
8	Blue Jays	656	5,599	.506	2,833	2,765	191,864	26,515	49,846	10,343	920	6,567	25,282	18,204	2,034	38,920	3,221	1,177	214,620	81,730	17,830	925	1,593	961	4,400	.260	.328	.426	.754
9	Giants	497	5,599	.517	2,894	2,704	190,573	24,841	48,801	9,478	1,177	5,439	23,571	18,405	1,767	39,139	2,945	1,302	214,448	76,950	16,094	2,145	1,558	1,833	4,193	.256	.325	.404	.729
10	Mets	444	5,596	.500	2,798	2,798	189,705	24,659	48,108	9,355	927	5,672	23,475	18,429	2,013	39,171	3,381	1,313	213,650	76,333	15,954	2,002	1,501	1,565	4,106	.254	.324	.402	.726
11	Athletics	349	5,598	.508	2,844	2,754	190,350	25,926	47,923	9,551	778	6,182	24,637	20,282	1,917	39,727	3,028	1,101	215,107	77,576	16,511	989	1,569	957	4,411	.252	.327	.408	.735
12	Cubs	75	5,596	.494	2,765	2,829	190,853	25,195	48,759	9,484	1,052	6,100	23,943	17,897	1,944	41,247	3,043	1,340	214,107	78,647	16,636	2,013	1,400	1,422	4,090	.255	.323	.412	.736
13	Mariners	-83	5,595	.499	2,790	2,805	191,285	25,538	49,265	9,379	810	6,104	24,329	18,421	1,969	39,589	3,558	1,378	214,470	78,576	16,293	1,256	1,539	1,263	4,148	.258	.327	.411	.737
14	Phillies	-96	5,598	.501	2,806	2,792	191,401	25,404	48,982	9,694	1,159	5,698	24,111	19,030	1,914	40,908	3,602	1,052	215,647	78,088	16,551	1,854	1,448	1,636	3,901	.256	.327	.408	.735
15	Angels	-139	5,599	.503	2,819	2,780	191,163	25,645	49,824	9,302	898	5,815	24,343	17,415	1,834	37,578	3,658	1,662	213,238	78,367	16,015	1,298	1,528	1,228	4,358	.261	.326	.410	.736
16	Rangers	-139	5,601	.499	2,792	2,808	192,730	27,606	50,908	9,958	955	6,722	26,255	18,122	1,854	40,067	3,411	1,336	215,529	82,942	17,635	1,194	1,629	1,101	4,136	.264	.331	.430	.761
17	Diamondbacks	-280	4,369	.488	2,134	2,235	149,057	19,998	37,968	7,790	1,077	4,686	19,062	14,528	1,448	33,021	2,531	912	167,594	61,970	13,553	1,337	1,224	1,096	3,113	.255	.324	.416	.740
18	Brewers	-393	5,598	.493	2,758	2,839	190,000	25,425	48,453	9,556	1,002	5,960	24,179	18,705	2,120	41,634	3,929	1,545	214,093	77,893	16,518	1,776	1,492	1,314	4,167	.255	.326	.410	.736
19	White Sox	-395	5,599	.493	2,759	2,837	190,930	25,840	49,757	9,218	942	6,165	24,661	17,471	1,869	38,032	3,424	1,525	213,275	79,354	16,325	1,431	1,574	1,013	4,362	.261	.326	.416	.742
20	Rays	-413	4,367	.490	2,141	2,226	148,479	19,435	37,705	7,504	856	4,557	18,485	14,101	1,692	33,813	3,272	1,245	166,188	60,592	12,917	747	1,169	693	3,058	.254	.323	.408	.731
21	Twins	-666	5,597	.491	2,749	2,847	192,290	25,925	50,668	10,096	1,111	5,344	24,518	17,801	1,927	38,169	3,241	1,431	214,597	79,018	16,551	971	1,608	1,105	4,571	.263	.330	.411	.740
22	Reds	-796	5,603	.486	2,720	2,880	190,121	25,199	48,477	9,536	947	6,120	23,939	18,508	2,069	41,974	4,044	1,556	214,242	78,267	16,603	2,093	1,451	1,440	3,915	.255	.325	.412	.737
23	Nationals	-988	5,596	.481	2,692	2,903	189,345	24,197	48,364	9,820	1,019	5,323	22,895	17,571	1,941	39,417	3,984	1,554	212,527	76,191	16,162	2,224	1,446	1,505	4,121	.255	.323	.402	.725
24	Padres	-1,043	5,602	.482	2,698	2,904	189,574	23,812	47,515	9,016	989	5,237	22,551	18,504	1,631	41,113	3,614	1,407	213,057	74,220	15,242	1,851	1,497	1,375	4,153	.251	.320	.392	.712
25	Orioles	-1,561	5,595	.472	2,642	2,950	191,847	25,704	49,765	9,604	758	6,458	24,546	17,586	1,900	37,999	2,908	1,212	213,994	80,259	16,820	1,104	1,557	1,007	4,398	.259	.325	.418	.744