The Los Angeles Dodgers had the highest run differential by a team in 2020, with a differential of 136 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	136	2020	60	.717	43	17	2,042	349	523	97	6	118	327	228	30	471	29	8	2,315	986	221	3	12	7	46	.256	.338	.483	.821
2	Padres	84	2020	60	.617	37	23	1,972	325	506	103	12	95	312	204	28	479	55	13	2,230	918	210	12	14	6	37	.257	.333	.466	.798
3	Braves	60	2020	60	.583	35	25	2,074	348	556	130	3	103	338	239	23	573	23	4	2,344	1,001	236	1	7	13	39	.268	.349	.483	.832
4	White Sox	60	2020	60	.583	35	25	2,047	306	534	94	6	96	294	179	24	571	20	8	2,264	928	196	1	13	1	44	.261	.326	.453	.779
5	Rays	60	2020	60	.667	40	20	1,975	289	470	105	12	80	274	243	28	608	48	9	2,260	839	197	0	14	9	38	.238	.328	.425	.753
6	Twins	54	2020	60	.600	36	24	1,937	269	468	81	3	91	258	186	29	528	14	7	2,168	828	175	2	14	9	38	.242	.315	.427	.743
7	Yankees	45	2020	60	.550	33	27	1,915	315	473	87	7	94	301	251	30	480	27	7	2,208	856	188	1	11	5	51	.247	.342	.447	.789
8	Athletics	42	2020	60	.600	36	24	1,908	274	430	91	11	71	264	238	39	524	26	3	2,201	756	173	2	14	5	44	.225	.322	.396	.718
9	Indians	39	2020	60	.583	35	25	1,959	248	446	96	5	59	234	239	24	517	25	10	2,245	729	160	7	16	4	40	.228	.317	.372	.689
10	Cubs	25	2020	60	.567	34	26	1,918	265	422	82	8	74	248	229	52	568	24	10	2,213	742	164	1	13	9	42	.220	.318	.387	.705
11	Cardinals	11	2020	58	.517	30	28	1,752	240	410	73	7	51	231	205	33	477	18	10	2,010	650	131	4	16	3	38	.234	.323	.371	.694
12	Astros	4	2020	60	.483	29	31	1,992	279	478	103	12	69	268	192	23	440	22	11	2,226	812	184	6	13	5	39	.240	.312	.408	.720
13	Giants	2	2020	60	.483	29	31	2,019	299	532	107	14	81	290	195	27	499	19	8	2,258	910	202	4	13	8	51	.263	.335	.451	.785
14	Reds	0	2020	60	.517	31	29	1,842	243	390	76	3	90	237	239	33	534	29	9	2,121	742	169	0	7	4	44	.212	.312	.403	.715
15	Phillies	-5	2020	60	.467	28	32	1,948	306	500	90	10	82	289	229	28	480	35	8	2,223	856	182	8	10	16	40	.257	.342	.439	.781
16	Nationals	-8	2020	60	.433	26	34	1,968	293	519	112	12	66	279	192	32	451	33	12	2,218	853	190	5	21	16	42	.264	.336	.433	.769
17	Blue Jays	-10	2020	60	.533	32	28	2,023	302	516	104	4	88	288	203	12	508	33	6	2,260	892	196	8	14	4	39	.255	.325	.441	.766
18	Brewers	-17	2020	60	.483	29	31	1,920	247	429	83	5	75	238	221	35	582	15	11	2,186	747	163	0	10	8	53	.223	.313	.389	.702
19	Orioles	-20	2020	60	.417	25	35	2,026	274	523	102	7	77	264	164	27	514	19	14	2,242	870	186	15	10	5	32	.258	.321	.429	.750
20	Mets	-22	2020	60	.433	26	34	2,023	286	551	106	7	86	278	197	45	498	20	10	2,279	929	199	1	13	8	53	.272	.348	.459	.807
21	Royals	-24	2020	60	.433	26	34	1,988	248	485	97	7	68	237	172	18	527	49	20	2,196	800	172	8	10	3	28	.244	.309	.402	.711
22	Diamondbacks	-26	2020	60	.417	25	35	1,997	269	482	101	12	58	255	181	36	461	23	7	2,238	781	171	1	23	5	37	.241	.312	.391	.704
23	Angels	-27	2020	60	.433	26	34	2,020	294	501	97	8	85	285	239	25	490	21	8	2,308	869	190	6	18	8	49	.248	.332	.430	.763
24	Marlins	-41	2020	60	.517	31	29	1,935	263	472	82	5	60	247	191	25	537	51	14	2,166	744	147	6	9	6	37	.244	.319	.384	.703
25	Mariners	-49	2020	60	.450	27	33	1,929	254	435	88	5	60	244	207	30	545	50	16	2,181	713	153	3	12	5	35	.226	.309	.370	.678