The Boston Red Sox have the highest run differential by a team in a postseason, with a differential of 53 runs in 2007.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	53	2007	14	.786	11	3	476	99	149	41	1	18	96	66	4	85	6	1	559	246	60	4	9	8	23	.313	.395	.517	.911
2	Braves	39	1996	16	.563	9	7	539	80	144	23	4	17	79	60	5	111	12	8	619	226	44	8	7	6	11	.267	.342	.419	.761
3	Dodgers	35	2020	18	.722	13	5	602	101	153	33	2	30	97	83	7	167	10	1	697	280	65	1	4	4	8	.254	.349	.465	.814
4	Blue Jays	33	2025	16	.625	10	6	591	100	168	29	2	27	94	55	8	108	2	1	663	282	58	3	6	7	8	.284	.350	.477	.827
5	Red Sox	33	2018	14	.786	11	3	501	84	121	25	1	17	80	59	6	120	7	3	571	199	43	2	3	7	7	.242	.327	.397	.724
6	White Sox	33	2005	12	.917	11	1	416	67	113	25	3	18	67	36	12	77	13	7	474	198	46	8	2	3	10	.272	.345	.476	.821
7	Phillies	30	2023	13	.615	8	5	418	61	105	25	1	24	58	50	3	120	16	3	475	204	50	1	3	5	9	.251	.333	.488	.821
8	Rangers	30	2023	17	.765	13	4	600	97	151	29	3	30	91	66	7	148	10	0	675	276	62	0	2	3	11	.252	.332	.460	.792
9	Orioles	30	1970	8	.875	7	1	280	60	86	14	0	16	56	32	1	52	1	2	318	148	30	3	2	4	7	.307	.378	.529	.906
10	Dodgers	29	2017	15	.667	10	5	496	82	120	23	5	23	76	65	9	133	6	5	579	222	51	5	4	3	10	.242	.338	.448	.786
11	Red Sox	28	2013	16	.688	11	5	520	72	118	29	3	10	67	59	8	165	12	2	594	183	42	2	5	8	10	.227	.313	.352	.664
12	Yankees	28	2009	15	.733	11	4	522	80	134	24	2	20	75	65	9	125	7	3	605	222	46	5	4	7	9	.257	.347	.425	.772
13	Diamondbacks	28	2001	17	.647	11	6	574	69	142	25	0	11	67	53	8	131	6	5	650	200	36	13	2	13	14	.247	.319	.348	.667
14	Yankees	28	1998	13	.846	11	2	427	62	109	19	1	14	58	62	4	95	12	5	502	172	34	5	4	5	14	.255	.352	.403	.755
15	Yankees	28	1960	7	.429	3	4	269	55	91	13	4	10	54	18	2	40	0	2	292	142	27	2	1	3	5	.338	.383	.528	.911
16	Yankees	27	1999	12	.917	11	1	411	58	102	15	2	15	54	41	2	94	8	2	460	166	32	6	0	8	4	.248	.319	.404	.723
17	Braves	26	1995	14	.786	11	3	496	69	140	24	1	19	64	53	3	83	10	5	560	223	44	6	2	11	13	.282	.354	.450	.803
18	Orioles	25	1983	9	.778	7	2	293	37	63	17	0	9	34	26	3	61	3	0	329	107	26	1	6	5	8	.215	.280	.365	.646
19	Dodgers	24	2024	16	.688	11	5	531	95	126	15	2	27	91	74	7	123	14	3	624	226	44	5	7	3	5	.237	.334	.426	.760
20	Royals	24	2015	16	.688	11	5	562	90	146	26	3	17	83	44	7	108	14	3	627	229	46	4	10	6	8	.260	.316	.407	.724
21	Cardinals	23	2011	18	.611	11	7	616	100	167	35	4	18	92	72	8	135	7	5	711	264	57	12	3	16	15	.271	.353	.429	.782
22	Athletics	23	1989	9	.889	8	1	304	58	87	17	4	16	53	38	2	54	17	3	349	160	37	3	2	3	4	.286	.367	.526	.893
23	Twins	23	1987	12	.667	8	4	409	72	110	23	4	15	71	49	8	61	10	2	471	186	42	3	2	6	3	.269	.357	.455	.812
24	Giants	22	2012	16	.688	11	5	538	69	127	21	6	14	62	48	1	131	5	2	596	202	41	6	3	4	7	.236	.298	.375	.674
25	Reds	22	1976	7	1.000	7	0	233	41	67	15	6	7	38	27	0	32	12	5	266	115	28	1	5	5	6	.288	.355	.494	.848