Since 2000, the New York Yankees have the highest run differential by a team, with a differential of 2,908 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,908	4,018	.580	2,328	1,688	137,244	20,434	35,900	6,781	499	5,470	19,576	14,883	1,603	29,497	2,464	778	155,450	60,089	12,750	595	1,125	781	3,243	.262	.338	.438	.776
2	Dodgers	2,685	4,022	.568	2,284	1,738	136,621	18,678	35,206	6,910	695	4,512	17,819	13,832	1,509	29,302	2,355	860	154,310	57,042	12,117	1,269	1,079	1,078	3,000	.258	.330	.418	.748
3	Red Sox	2,037	4,022	.543	2,183	1,839	139,718	20,483	37,556	8,354	648	4,735	19,511	14,163	1,475	29,756	2,110	703	157,049	61,411	13,737	492	1,201	967	3,196	.269	.340	.440	.779
4	Cardinals	1,842	4,018	.552	2,217	1,801	136,577	18,863	35,804	7,031	597	4,410	17,955	13,330	1,638	28,538	1,931	826	154,068	57,259	12,038	1,396	1,127	1,108	3,133	.262	.333	.419	.752
5	Braves	1,796	4,016	.544	2,184	1,831	137,041	18,654	35,546	7,098	607	4,548	17,818	13,412	1,315	30,270	1,994	789	154,133	57,502	12,253	1,354	1,011	1,059	3,099	.259	.329	.420	.749
6	Astros	937	4,020	.515	2,071	1,948	136,693	18,514	35,277	7,057	627	4,623	17,665	12,956	1,531	29,225	2,305	918	153,405	57,457	12,307	1,145	1,080	819	3,203	.258	.327	.420	.747
7	Guardians	874	4,016	.518	2,082	1,934	136,894	18,780	35,360	7,346	634	4,359	17,892	13,413	1,575	29,156	2,439	875	153,875	57,051	12,339	825	1,168	770	3,043	.258	.329	.417	.746
8	Athletics	580	4,021	.512	2,060	1,961	136,776	18,273	34,131	7,041	581	4,418	17,415	13,918	1,438	29,505	1,915	620	153,747	55,588	12,040	530	1,085	611	3,174	.250	.323	.406	.729
9	Giants	556	4,019	.521	2,093	1,925	136,695	17,594	34,883	7,020	853	3,905	16,748	12,948	1,301	28,836	1,809	763	153,398	55,324	11,778	1,317	1,137	1,240	3,135	.255	.323	.405	.728
10	Cubs	450	4,020	.501	2,014	2,005	136,689	18,127	34,676	7,002	720	4,527	17,265	13,160	1,573	31,407	2,051	840	153,728	56,699	12,249	1,325	981	953	2,962	.254	.324	.415	.739
11	Blue Jays	419	4,019	.502	2,016	2,003	137,563	18,977	35,501	7,449	576	4,905	18,127	12,902	1,442	28,909	1,943	721	153,551	58,817	12,930	563	1,081	593	3,214	.258	.326	.428	.753
12	Phillies	331	4,020	.513	2,062	1,958	137,348	18,462	34,958	7,021	798	4,477	17,608	13,621	1,508	30,786	2,593	694	154,670	57,006	12,296	1,201	992	1,133	2,781	.255	.326	.415	.741
13	Angels	326	4,020	.515	2,069	1,951	137,143	18,485	35,599	6,797	657	4,348	17,598	12,191	1,445	28,032	2,690	1,061	152,719	56,754	11,802	820	1,120	878	3,088	.260	.324	.414	.738
14	Mets	191	4,019	.503	2,021	1,998	136,208	17,634	34,373	6,799	658	4,242	16,830	13,165	1,624	29,550	2,406	814	153,293	55,214	11,699	1,286	1,010	1,053	2,994	.252	.323	.405	.729
15	Twins	-35	4,021	.502	2,020	2,001	137,865	18,575	35,849	7,256	769	4,150	17,624	12,839	1,401	29,276	2,097	867	153,908	57,093	12,175	691	1,112	753	3,135	.260	.327	.414	.741
16	Rays	-138	4,019	.497	1,999	2,020	136,507	17,927	34,491	6,931	779	4,273	17,070	13,027	1,586	31,479	3,053	1,113	152,855	55,799	11,983	660	1,075	640	2,756	.253	.323	.409	.731
17	Mariners	-171	4,020	.500	2,012	2,008	137,040	17,647	34,645	6,542	579	4,194	16,799	12,688	1,494	30,218	2,573	930	153,041	54,927	11,315	775	1,044	767	2,886	.253	.321	.401	.721
18	Brewers	-271	4,023	.497	1,999	2,023	135,895	17,899	34,074	6,865	675	4,625	17,099	13,259	1,668	32,616	2,715	913	153,020	56,164	12,165	1,235	963	924	3,022	.251	.323	.413	.736
19	Rangers	-327	4,022	.491	1,973	2,049	138,076	19,533	36,006	7,124	661	4,967	18,607	12,501	1,465	30,002	2,450	878	153,888	59,353	12,752	728	1,118	685	2,886	.261	.326	.430	.756
20	Diamondbacks	-376	4,020	.487	1,958	2,062	137,057	18,297	34,840	7,223	980	4,272	17,451	13,367	1,322	30,530	2,308	830	154,093	56,839	12,475	1,223	1,124	1,009	2,879	.254	.324	.415	.739
21	White Sox	-674	4,021	.481	1,934	2,087	136,817	18,101	35,134	6,651	562	4,647	17,346	11,681	1,521	29,529	2,239	989	151,918	56,850	11,860	877	1,022	549	3,113	.257	.320	.416	.736
22	Padres	-888	4,021	.479	1,927	2,094	135,688	16,956	33,568	6,506	727	3,857	16,117	13,310	1,246	31,050	2,499	886	152,485	53,099	11,090	1,192	1,049	859	2,906	.247	.318	.391	.709
23	Nationals	-924	4,019	.475	1,908	2,111	135,786	17,464	34,605	7,042	663	4,010	16,607	12,865	1,454	29,590	2,483	967	152,595	55,003	11,715	1,465	1,025	1,031	3,072	.255	.324	.405	.729
24	Reds	-1,146	4,023	.472	1,899	2,122	136,338	17,935	34,294	6,800	603	4,609	17,126	13,242	1,703	31,775	2,547	964	153,656	56,127	12,012	1,394	979	934	2,850	.252	.323	.412	.735
25	Tigers	-1,282	4,017	.470	1,888	2,129	137,707	17,943	35,855	6,877	952	4,140	17,169	11,812	1,236	30,143	1,822	824	152,582	57,056	11,969	738	1,089	676	3,105	.260	.322	.414	.736