Since August 12, 2025, the New York Yankees have the highest run differential by a team, with a differential of 79 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	79	43	.721	31	12	1,442	247	368	62	3	87	243	192	12	426	49	14	1,664	697	152	2	16	11	27	.255	.344	.483	.828
2	Dodgers	60	43	.581	25	18	1,435	210	354	62	6	67	197	141	14	346	17	5	1,612	629	135	6	16	8	28	.247	.317	.438	.755
3	Padres	43	43	.535	23	20	1,444	209	370	70	2	52	199	122	20	329	26	8	1,611	600	124	13	12	3	29	.256	.320	.416	.736
4	Phillies	37	44	.614	27	17	1,508	223	405	72	8	70	221	133	18	385	26	9	1,677	703	150	3	15	5	23	.269	.332	.466	.798
5	Mariners	35	43	.558	24	19	1,448	219	358	78	3	67	210	136	25	384	36	9	1,624	643	148	3	12	10	28	.247	.320	.444	.764
6	Brewers	34	44	.523	23	21	1,523	212	398	84	5	44	198	165	19	338	34	10	1,724	624	133	5	12	3	35	.261	.339	.410	.748
7	Blue Jays	33	43	.581	25	18	1,428	215	362	76	4	54	212	122	17	301	21	7	1,588	608	134	7	14	4	41	.254	.317	.426	.743
8	Royals	30	43	.535	23	20	1,435	210	365	82	3	54	204	138	18	277	19	7	1,604	615	139	4	9	3	29	.254	.326	.429	.754
9	Cubs	27	45	.556	25	20	1,473	194	351	71	7	56	188	162	13	368	37	12	1,669	604	134	2	19	6	23	.238	.316	.410	.726
10	Red Sox	27	42	.571	24	18	1,443	187	370	77	4	40	175	132	16	346	39	9	1,607	575	121	4	12	4	32	.256	.323	.398	.722
11	Mets	21	44	.455	20	24	1,531	253	421	78	3	77	248	155	22	376	54	8	1,727	736	158	4	15	3	26	.275	.347	.481	.828
12	Rangers	19	42	.476	20	22	1,432	195	342	65	3	50	191	131	17	324	32	6	1,592	563	118	3	9	1	27	.239	.308	.393	.702
13	Athletics	17	41	.561	23	18	1,408	197	354	84	0	54	188	123	13	374	16	8	1,559	600	138	7	8	5	20	.251	.316	.426	.742
14	Giants	13	43	.512	22	21	1,437	216	345	61	6	60	204	149	17	371	16	7	1,621	598	127	0	18	5	24	.240	.315	.416	.731
15	Guardians	13	45	.600	27	18	1,463	177	320	65	6	45	173	119	16	387	41	6	1,615	532	116	8	9	8	16	.219	.283	.364	.647
16	Braves	8	44	.568	25	19	1,504	225	381	70	5	57	219	152	15	346	25	11	1,685	632	132	3	11	2	25	.253	.326	.420	.746
17	Diamondbacks	5	43	.535	23	20	1,461	205	369	67	11	48	195	132	21	379	43	10	1,644	602	126	14	16	8	24	.253	.320	.412	.732
18	Pirates	2	42	.476	20	22	1,391	156	318	79	4	33	148	147	16	383	25	9	1,564	504	116	4	6	4	32	.229	.308	.362	.671
19	Reds	-3	42	.500	21	21	1,418	176	341	58	9	47	169	133	7	380	18	5	1,575	558	114	4	13	3	28	.240	.306	.394	.700
20	Tigers	-11	42	.429	18	24	1,420	181	334	60	11	43	167	148	16	395	10	3	1,598	545	114	0	14	4	22	.235	.312	.384	.695
21	Rays	-12	42	.452	19	23	1,423	176	356	62	3	48	172	115	12	379	43	9	1,563	568	113	4	9	1	31	.250	.310	.399	.709
22	White Sox	-19	43	.395	17	26	1,452	194	354	60	1	48	190	121	17	368	11	2	1,600	560	109	4	6	0	32	.244	.308	.386	.694
23	Orioles	-23	44	.500	22	22	1,480	172	328	58	6	47	164	163	18	437	40	8	1,670	539	111	1	8	4	21	.222	.305	.364	.669
24	Marlins	-29	44	.500	22	22	1,522	204	377	76	9	41	191	126	26	317	41	12	1,688	594	126	0	14	2	24	.248	.313	.390	.704
25	Astros	-34	43	.465	20	23	1,452	166	328	58	1	49	157	125	16	372	26	5	1,601	535	108	3	5	6	29	.226	.293	.368	.662