The New York Yankees have the highest run differential by a team with 60+ games played, with a differential of 13,139 runs.

Interpreted as:

best run differential through 60 or more games

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,139	19,074	.570	10,815	8,171	650,080	92,689	172,578	28,658	5,497	17,338	86,126	68,645	4,933	94,949	11,659	2,804	736,543	264,244	51,493	9,595	3,290	2,838	10,693	.265	.339	.406	.745
2	Giants	7,475	21,785	.535	11,575	10,047	743,479	100,707	195,539	31,367	7,039	15,597	90,179	68,349	5,682	99,692	16,528	3,147	832,195	287,775	54,003	11,669	3,016	4,019	10,197	.263	.329	.387	.716
3	Dodgers	6,257	21,701	.532	11,469	10,093	739,443	97,997	193,203	31,082	7,006	14,156	88,215	68,956	5,154	100,471	17,349	3,553	829,468	280,765	52,244	12,774	3,065	3,739	9,955	.261	.327	.380	.707
4	Cubs	3,621	22,316	.513	11,365	10,790	763,689	102,769	200,009	33,781	7,362	15,265	88,354	68,618	5,288	105,153	15,812	3,074	853,536	294,309	56,408	13,027	2,914	3,523	9,971	.262	.326	.385	.711
5	Red Sox	3,590	19,365	.518	9,985	9,297	662,789	90,435	176,851	33,150	5,600	14,618	83,869	66,861	4,810	95,713	9,641	2,552	748,399	265,055	53,368	10,597	3,342	3,000	11,557	.267	.337	.400	.737
6	Guardians	2,250	19,372	.513	9,885	9,396	660,253	87,574	174,780	31,168	5,500	13,930	80,937	62,665	4,840	94,710	11,920	3,390	742,581	258,738	50,598	11,464	3,359	2,548	10,535	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,954	20,666	.513	10,538	9,997	706,893	92,464	187,847	31,850	7,052	12,869	84,523	64,225	5,206	98,253	15,018	3,617	791,443	272,408	51,771	11,974	3,145	3,776	10,143	.266	.330	.385	.715
9	Braves	1,532	22,277	.504	11,141	10,982	762,716	99,557	198,081	32,124	6,301	15,068	86,602	67,545	5,071	100,260	14,103	3,069	850,898	288,011	53,493	12,685	2,881	3,656	10,389	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	759	21,902	.504	10,964	10,799	746,253	98,270	194,422	32,410	7,561	14,336	87,411	66,757	5,508	102,408	18,171	3,411	834,390	284,962	54,307	12,662	3,042	3,648	9,727	.261	.325	.382	.707
13	Astros	721	10,040	.502	5,042	4,993	340,710	42,808	86,856	15,922	2,173	8,442	40,289	32,379	2,908	63,025	7,155	3,136	382,744	132,450	26,537	4,030	2,717	3,145	7,422	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	377	7,613	.498	3,793	3,817	260,820	35,192	67,828	13,552	1,493	8,276	33,381	24,201	2,428	49,049	4,580	1,963	291,082	109,194	23,321	1,504	2,129	1,404	5,938	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	348	19,399	.503	9,717	9,589	661,529	89,085	174,763	29,617	6,298	14,593	82,036	65,595	4,453	96,865	11,293	2,939	745,696	260,755	50,508	11,009	3,110	2,448	10,723	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331