The New York Yankees have the highest run differential by a team, with a differential of 13,134 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,134	19,060	.570	10,805	8,167	649,624	92,633	172,468	28,637	5,493	17,320	86,072	68,591	4,929	94,833	11,650	2,800	736,023	264,051	51,450	9,595	3,284	2,832	10,680	.265	.339	.406	.745
2	Giants	7,481	21,770	.535	11,569	10,038	742,993	100,673	195,435	31,350	7,036	15,588	90,146	68,299	5,674	99,575	16,516	3,145	831,647	287,621	53,974	11,666	3,015	4,018	10,179	.263	.329	.387	.716
3	Dodgers	6,245	21,686	.532	11,461	10,086	738,924	97,916	193,075	31,056	7,006	14,132	88,136	68,902	5,148	100,347	17,342	3,550	828,884	280,539	52,194	12,774	3,060	3,733	9,944	.261	.327	.380	.707
4	Red Sox	3,591	19,348	.518	9,978	9,287	662,199	90,362	176,703	33,116	5,599	14,602	83,798	66,804	4,804	95,557	9,633	2,551	747,741	264,823	53,317	10,595	3,339	2,997	11,546	.267	.337	.400	.737
5	Cubs	3,591	22,302	.513	11,355	10,786	763,202	102,690	199,873	33,750	7,360	15,249	88,277	68,571	5,285	105,046	15,791	3,070	852,992	294,090	56,359	13,026	2,908	3,520	9,962	.262	.326	.385	.711
6	Guardians	2,243	19,358	.513	9,877	9,390	659,780	87,515	174,664	31,143	5,497	13,918	80,880	62,623	4,835	94,588	11,911	3,388	742,055	258,555	50,558	11,463	3,354	2,545	10,526	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,965	20,653	.513	10,531	9,991	706,462	92,408	187,741	31,829	7,049	12,860	84,469	64,189	5,200	98,147	15,014	3,615	790,965	272,248	51,738	11,973	3,141	3,775	10,136	.266	.330	.385	.715
9	Braves	1,530	22,263	.504	11,137	10,972	762,242	99,502	197,965	32,105	6,301	15,054	86,549	67,494	5,067	100,136	14,097	3,067	850,365	287,834	53,460	12,684	2,878	3,655	10,378	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	766	21,887	.504	10,958	10,790	745,754	98,210	194,300	32,383	7,557	14,325	87,355	66,708	5,506	102,282	18,166	3,405	833,834	284,772	54,265	12,662	3,036	3,646	9,717	.261	.325	.382	.707
13	Astros	726	10,025	.502	5,033	4,987	340,206	42,751	86,719	15,905	2,172	8,420	40,234	32,355	2,897	62,911	7,147	3,132	382,201	132,228	26,497	4,030	2,713	3,144	7,406	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	358	7,598	.498	3,783	3,812	260,321	35,118	67,699	13,530	1,491	8,256	33,311	24,137	2,423	48,968	4,573	1,963	290,506	108,979	23,277	1,500	2,125	1,401	5,927	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	343	19,383	.503	9,707	9,583	660,999	89,023	174,645	29,586	6,295	14,580	81,976	65,547	4,446	96,712	11,292	2,936	745,108	260,561	50,461	11,009	3,107	2,447	10,716	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331