biggest run differential in a single game since 1950

Since 1950, the Texas Rangers have the highest run differential by a team in a game, with a differential of 27 runs versus the Orioles on August 22, 2007.

Interpreted as:

biggest run differential in a single regular-season game since 1950

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rangers	27	8/22/2007	TEX	@	BAL	W 30-3	57	30	29	2	0	6	30	8	0	11	0	0	65	49	8	0	0	0	0	.509	.569	.860	1.429
2	Red Sox	25	6/8/1950	BSA	vs	SLA	W 29-4	53	29	28	9	1	7	29	11	0	2	0	0	64	60	17	0		0	0	.528	.609	1.132	1.741
3	Angels	24	6/24/2023	LAA	@	COL	W 25-1	52	25	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
4	Blue Jays	23	7/22/2022	TOR	@	BOS	W 28-5	57	28	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
5	White Sox	23	4/23/1955	CWS	@	KCA	W 29-6	54	29	29	5	0	7	28	6	1	4	1	1	63	55	12	0	2	1	0	.537	.571	1.019	1.590
6	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
7	Indians	22	8/31/2004	CLE	@	NYY	W 22-0	49	22	22	5	1	3	22	9	0	6	1	0	59	38	9	0	1	0	0	.449	.525	.776	1.301
8	Orioles	22	9/28/2000	BAL	vs	TOR	W 23-1	47	23	23	2	0	3	20	5	1	5	0	0	54	34	5	0	1	0	1	.489	.537	.723	1.260
9	Angels	22	8/25/1979	CAL	@	TOR	W 24-2	52	24	26	6	2	5	23	5	0	4	0	0	58	51	13	1	0	0	2	.500	.544	.981	1.525
10	Pirates	22	9/16/1975	PIT	@	CHC	W 22-0	53	22	24	2	1	2	21	6	1	5	0	0	61	34	5	0	1	0	0	.453	.508	.642	1.150
11	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
12	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	21	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
13	Dodgers	21	7/10/2021	LAD	vs	ARI	W 22-1	44	22	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
14	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
15	Nationals	21	7/31/2018	WSH	vs	NYM	W 25-4	50	25	26	5	2	5	25	8	1	6	2	0	59	50	12	0	0	1	0	.520	.593	1.000	1.593
16	Phillies	21	7/6/2009	PHI	vs	CIN	W 22-1	43	22	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
17	Royals	21	9/9/2004	KCR	@	DET	W 26-5	52	26	26	5	1	1	25	8	0	6	0	0	62	36	7	0	2	0	0	.500	.548	.692	1.241
18	Twins	21	6/4/2002	MIN	vs	CLE	W 23-2	50	23	25	6	1	3	22	7	0	4	0	0	57	42	10	0	0	1	0	.500	.561	.840	1.401
19	Athletics	21	9/30/2000	OAK	vs	TEX	W 23-2	48	23	24	5	0	4	23	10	0	10	0	0	58	41	9	0	0	0	0	.500	.586	.854	1.440
20	Yankees	21	6/19/2000	NYY	@	BOS	W 22-1	47	22	19	4	1	5	21	7	0	4	1	0	55	40	10	0	1	1	0	.404	.473	.851	1.324
21	Orioles	21	6/13/1999	BAL	@	ATL	W 22-1	51	22	25	7	0	4	22	6	0	8	0	0	57	44	11	0	0	0	0	.490	.544	.863	1.407
22	Yankees	21	8/12/1953	NYY	@	WSH	W 22-1	52	22	28	3	2	1	22	7	0	2	0	0	61	38	6	2		0	0	.538	.593	.731	1.324
23	Braves	20	9/9/2020	ATL	vs	MIA	W 29-9	47	29	23	2	0	7	28	9	1	9	2	0	58	46	9	0	1	0	0	.489	.569	.979	1.548
24	Astros	20	9/8/2019	HOU	vs	SEA	W 21-1	47	21	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
25	Mets	20	8/16/2018	NYM	@	PHI	W 24-4	52	24	25	7	1	3	19	7	1	5	1	0	61	43	11	1	0	1	2	.481	.550	.827	1.377