The Boston Red Sox had their highest run differential in a game versus the St. Louis Browns on June 8, 1950, with a differential of 25 runs.

Interpreted as:

biggest score differential in a regular-season game by red sox

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	25	6/8/1950	BSA	vs	SLA	W 29-4	53	29	28	9	1	7	29	11	0	2	0	0	64	60	17	0		0	0	.528	.609	1.132	1.741
2	Red Sox	20	6/18/1953	BOS	vs	DET	W 23-3	50	23	27	2	0	1	22	9	0	6	1	1	60	32	3	1		1	0	.540	.610	.640	1.250
3	Red Sox	20	9/27/1940	BSA	vs	WSH	W 24-4	44	24	22	4	1	2	21	9	0	6	0	0	53	34	7	0			2	.500	.585	.773	1.358
4	Red Sox	19	8/21/1986	BOS	@	CLE	W 24-5	51	24	24	2	0	3	23	9	1	2	0	0	61	35	5	0	0	0	0	.471	.557	.686	1.244
5	Red Sox	19	4/30/1950	BSA	vs	PHA	W 19-0	41	19	17	3	1	4	16	8	0	4	0	0	50	34	8	1		0	1	.415	.510	.829	1.339
6	Red Sox	19	6/24/1949	BSA	vs	SLA	W 21-2	48	21	25	3	0	2	20	12	0	4	2	0	60	34	5	0			1	.521	.617	.708	1.325
7	Red Sox	18	7/23/2002	BOS	vs	TBD	W 22-4	44	22	19	5	0	7	21	7	0	4	1	0	51	45	12	0	0	0	0	.432	.510	1.023	1.533
8	Red Sox	18	7/11/1954	BOS	@	PHA	W 18-0	50	18	22	6	0	3	17	7	0	4	0	0	58	37	9	1	0	1	1	.440	.509	.740	1.249
9	Red Sox	17	4/27/2024	BOS	vs	CHC	W 17-0	43	17	21	6	0	2	17	2	2	6	1	0	49	33	8	1	1	0	0	.488	.521	.767	1.288
10	Red Sox	17	6/27/2003	BOS	vs	FLA	W 25-8	46	25	28	8	1	3	25	7	1	7	0	0	57	47	12	0	3	0	1	.609	.632	1.022	1.653
11	Americans	17	4/24/1906	BSA	@	WSH	W 19-2	50	19	20	4	1	0	15	4	0		2		55	26	5	1				.400	.444	.520	.964
12	Red Sox	16	8/24/2023	BOS	@	HOU	W 17-1	49	17	25	6	0	3	17	6	2	7	1	0	58	40	9	0	1	0	2	.510	.569	.816	1.385
13	Red Sox	16	7/25/2019	BOS	vs	NYY	W 19-3	46	19	23	10	0	4	19	5	0	6	0	0	51	45	14	0	0	0	0	.500	.549	.978	1.527
14	Red Sox	16	9/26/2018	BOS	vs	BAL	W 19-3	45	19	22	9	0	5	19	3	0	7	1	0	48	46	14	0	0	0	1	.489	.521	1.022	1.543
15	Red Sox	16	9/4/2013	BOS	vs	DET	W 20-4	41	20	19	4	0	8	20	4	2	10	1	0	48	47	12	0	1	1	1	.463	.521	1.146	1.667
16	Red Sox	16	7/15/2005	BOS	vs	NYY	W 17-1	39	17	15	8	0	2	17	9	0	5	0	0	48	29	10	0	0	0	0	.385	.500	.744	1.244
17	Red Sox	16	5/28/2005	BOS	@	NYY	W 17-1	52	17	27	1	0	3	17	2	1	5	0	0	57	37	4	1	1	0	0	.519	.536	.712	1.247
18	Red Sox	16	6/26/1999	BOS	vs	CWS	W 17-1	38	17	14	5	0	5	17	4	1	6	0	0	44	34	10	0	1	0	0	.368	.432	.895	1.327
19	Red Sox	16	8/5/1997	BOS	@	TEX	W 17-1	49	17	24	6	0	4	17	4	1	8	0	0	55	42	10	0	1	0	1	.490	.527	.857	1.384
20	Red Sox	16	8/26/1957	BOS	@	KCA	W 16-0	45	16	19	4	0	6	16	4	0	3	1	0	49	41	10	0	0	0	0	.422	.469	.911	1.380
21	Red Sox	16	9/3/1956	BOS	@	WSH	W 16-0	41	16	20	4	1	1	16	7	1	2	1	0	50	29	6	0	1	0	3	.488	.560	.707	1.267
22	Red Sox	16	5/27/1955	BOS	vs	WSH	W 16-0	33	16	13	2	1	4	16	6	3	2	0	0	46	29	7	0	4	0	1	.394	.478	.879	1.357
23	Red Sox	16	6/17/1953	BOS	vs	DET	W 17-1	41	17	20	5	0	2	17	9	0	5	0	2	51	31	7	1		1	0	.488	.580	.756	1.336
24	Red Sox	16	6/7/1950	BSA	vs	SLA	W 20-4	45	20	23	4	0	5	20	7	0	7	0	0	52	42	9	0		0	1	.511	.577	.933	1.510
25	Americans	16	8/2/1901	BSA	@	PHA	W 16-0	51	16	22	5	0	0	14	2	0	1	3	-9	53	27	5	0		-9	-9	.431	.453	.529	.982