biggest win margin in one game in mlb history after 2000

Since 2001, the Texas Rangers have the highest run differential by a team in a game, with a differential of 27 runs versus the Orioles on August 22, 2007.

Interpreted as:

biggest win margin in one regular-season game in MLB history after 2000

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rangers	27	8/22/2007	TEX	@	BAL	W 30-3	57	30	29	2	0	6	30	8	0	11	0	0	65	49	8	0	0	0	0	.509	.569	.860	1.429
2	Angels	24	6/24/2023	LAA	@	COL	W 25-1	52	25	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
3	Blue Jays	23	7/22/2022	TOR	@	BOS	W 28-5	57	28	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
4	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
5	Indians	22	8/31/2004	CLE	@	NYY	W 22-0	49	22	22	5	1	3	22	9	0	6	1	0	59	38	9	0	1	0	0	.449	.525	.776	1.301
6	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
7	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	21	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
8	Dodgers	21	7/10/2021	LAD	vs	ARI	W 22-1	44	22	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
9	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
10	Nationals	21	7/31/2018	WSH	vs	NYM	W 25-4	50	25	26	5	2	5	25	8	1	6	2	0	59	50	12	0	0	1	0	.520	.593	1.000	1.593
11	Phillies	21	7/6/2009	PHI	vs	CIN	W 22-1	43	22	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
12	Royals	21	9/9/2004	KCR	@	DET	W 26-5	52	26	26	5	1	1	25	8	0	6	0	0	62	36	7	0	2	0	0	.500	.548	.692	1.241
13	Twins	21	6/4/2002	MIN	vs	CLE	W 23-2	50	23	25	6	1	3	22	7	0	4	0	0	57	42	10	0	0	1	0	.500	.561	.840	1.401
14	Braves	20	9/9/2020	ATL	vs	MIA	W 29-9	47	29	23	2	0	7	28	9	1	9	2	0	58	46	9	0	1	0	0	.489	.569	.979	1.548
15	Astros	20	9/8/2019	HOU	vs	SEA	W 21-1	47	21	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
16	Mets	20	8/16/2018	NYM	@	PHI	W 24-4	52	24	25	7	1	3	19	7	1	5	1	0	61	43	11	1	0	1	2	.481	.550	.827	1.377
17	Brewers	20	4/22/2010	MIL	@	PIT	W 20-0	52	20	25	7	1	4	20	6	0	8	2	0	59	46	12	0	1	0	0	.481	.525	.885	1.410
18	Royals	19	9/19/2025	KCR	vs	TOR	W 20-1	51	20	27	7	0	3	20	5	0	6	1	0	56	43	10	0	0	0	0	.529	.571	.843	1.415
19	Blue Jays	19	8/6/2025	TOR	@	COL	W 20-1	49	20	24	7	1	5	20	4	2	6	0	0	57	48	13	0	2	0	0	.490	.526	.980	1.506
20	Blue Jays	19	5/23/2023	TOR	@	TBR	W 20-1	52	20	27	3	1	4	18	1	0	9	2	0	54	44	8	0	1	0	1	.519	.519	.846	1.365
21	Braves	19	5/21/2021	ATL	vs	PIT	W 20-1	41	20	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
22	Brewers	19	9/9/2020	MIL	@	DET	W 19-0	45	19	21	8	0	5	18	7	2	6	0	1	54	44	13	0	0	0	2	.467	.556	.978	1.533
23	Phillies	19	4/7/2018	PHI	vs	MIA	W 20-1	42	20	20	4	0	4	20	6	0	11	0	0	49	36	8	0	1	0	1	.476	.531	.857	1.388
24	Angels	19	7/2/2016	LAA	@	BOS	W 21-2	50	21	22	6	1	4	19	3	1	5	0	0	55	42	11	0	1	0	0	.440	.473	.840	1.313
25	Twins	19	5/21/2009	MIN	@	CWS	W 20-1	46	20	20	4	0	4	18	5	1	5	0	0	54	36	8	1	1	1	0	.435	.491	.783	1.273