Corey Kluber was 6-4 with an ERA of 2.91 and 89 strikeouts in 13 appearances against the Astros in his career.
| NAME | DATE | TM | OPP | DEC | GS | CG | GF | SHO | SV | IP | H | TBF | R | ER | HR | BB | IBB | HBP | SO | WP | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Corey Kluber | 4/20/2013 |  CLE | @ |  HOU | W | 0 | 0 | 1 | 0 | 0 | 4.0 | 2 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 |
| | Corey Kluber | 9/22/2013 | CLE | vs | HOU | W | 1 | 0 | 0 | 0 | 0 | 5.1 | 6 | 20 | 2 | 2 | 1 | 1 | 0 | 0 | 6 | 0 |
| | Corey Kluber | 9/16/2014 | CLE | @ | HOU | W | 1 | 0 | 0 | 0 | 0 | 7.0 | 7 | 30 | 1 | 1 | 0 | 2 | 0 | 0 | 14 | 0 |
| | Corey Kluber | 4/6/2015 | CLE | @ | HOU | L | 1 | 0 | 0 | 0 | 0 | 7.1 | 3 | 26 | 2 | 2 | 0 | 2 | 0 | 0 | 7 | 0 |
| | Corey Kluber | 7/7/2015 | CLE | vs | HOU | W | 1 | 0 | 0 | 0 | 0 | 6.2 | 5 | 27 | 0 | 0 | 0 | 2 | 0 | 0 | 7 | 0 |
| | Corey Kluber | 5/9/2016 | CLE | @ | HOU | L | 1 | 0 | 0 | 0 | 0 | 2.2 | 5 | 16 | 5 | 5 | 0 | 3 | 0 | 0 | 3 | 0 |
| | Corey Kluber | 9/6/2016 | CLE | vs | HOU | L | 1 | 0 | 0 | 0 | 0 | 7.0 | 4 | 28 | 4 | 4 | 1 | 3 | 0 | 0 | 9 | 0 |
| | Corey Kluber | 4/27/2017 | CLE | vs | HOU | W | 1 | 0 | 0 | 0 | 0 | 7.0 | 8 | 32 | 3 | 3 | 1 | 4 | 0 | 0 | 10 | 0 |
| | Corey Kluber | 5/19/2018 | CLE | @ | HOU | W | 1 | 0 | 0 | 0 | 0 | 7.0 | 6 | 27 | 2 | 2 | 1 | 0 | 0 | 1 | 10 | 0 |
| | Corey Kluber | 5/25/2018 | CLE | vs | HOU | 1 | 0 | 0 | 0 | 0 | 6.1 | 7 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | |
| | Corey Kluber | 4/26/2019 | CLE | @ | HOU | 1 | 0 | 0 | 0 | 0 | 5.0 | 6 | 25 | 3 | 3 | 0 | 3 | 0 | 0 | 6 | 0 | |
 | Corey Kluber | 9/21/2022 |  TBR | vs | HOU | 1 | 0 | 0 | 0 | 0 | 7.0 | 6 | 28 | 1 | 1 | 0 | 1 | 0 | 1 | 2 | 0 | |
| | Corey Kluber | 10/2/2022 | TBR | @ | HOU | L | 1 | 0 | 0 | 0 | 0 | 5.0 | 6 | 21 | 2 | 2 | 1 | 1 | 0 | 0 | 4 | 0 |
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| NL East | W | L | PCT | GB | |
|---|---|---|---|---|---|
| 1 |  Braves | 104 | 58 | .642 | |
| 2 |  Phillies | 90 | 72 | .556 | 14.0 |
| AL East | W | L | PCT | GB | |
| 1 |  Orioles | 101 | 61 | .623 | |
| 2 | Rays | 99 | 63 | .611 | 2.0 |
| NL West | W | L | PCT | GB | |
| 1 |  Dodgers | 100 | 62 | .617 | |
| 2 |  Diamondbacks | 84 | 78 | .519 | 16.0 |
| NL Central | W | L | PCT | GB | |
| 1 |  Brewers | 92 | 70 | .568 | |
| 2 |  Cubs | 83 | 79 | .512 | 9.0 |
| AL West | W | L | PCT | GB | |
| 1 | Astros | 90 | 72 | .556 | |
| 2 |  Rangers | 90 | 72 | .556 | |
| AL Central | W | L | PCT | GB | |
| 1 |  Twins | 87 | 75 | .537 | |
| 2 |  Tigers | 78 | 84 | .481 | 9.0 |
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