Luke Hudson has the highest ERA in a game, with an ERA of 270.00 against the Cleveland Indians on August 13, 2006.

Interpreted as:

highest earned run average by a player in a regular-season game

	NAME	ERA	DATE	TM		OPP	DEC	GS	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Luke Hudson L. Hudson	270.00	8/13/2006	KCR	@	CLE	L	1	1	0	0	0	0.1	8	10	11	1	3	0	0	0	13	0
2	Mark Redman M. Redman	243.00	9/23/2006	KCR	vs	DET	L	1	0	0	0	0	0.1	7	9	9	1	2	0	0	0	10	0
3	Jose Mesa J. Mesa	243.00	5/28/2000	SEA	@	TBD	L	0	0	0	0	0	0.1	7	9	9	1	2	0	0	0	10	0
4	Lou Brissie L. Brissie	243.00	6/18/1950	PHA	@	CLE	L	1	0	0	0	0	0.1	3	9	9	0	6	0	0	0	10	0
5	Fred Heimach F. Heimach	243.00	7/17/1933	BKN	@	PIT		0	0	0	0	0	0.1	7	9	9	0	1	0	0		10	0
6	Paolo Espino P. Espino	216.00	7/18/2023	WSH	@	CHC		0	1	0	0	0	0.1	7	8	8	0	2	0	0	0	10	0
7	Cody Bolton C. Bolton	216.00	5/29/2023	PIT	@	SFG		0	0	0	0	0	0.1	6	8	8	1	2	0	0	0	9	0
8	Matt Shoemaker M. Shoemaker	216.00	6/4/2021	MIN	@	KCR	L	1	1	0	0	0	0.1	6	8	9	1	2	0	0	0	10	0
9	Taylor Williams T. Williams	216.00	6/4/2019	MIL	vs	MIA		0	1	0	0	0	0.1	6	8	8	0	2	0	0	1	9	0
10	Felix Hernandez F. Hernandez	216.00	6/12/2015	SEA	@	HOU	L	1	1	0	0	0	0.1	5	8	8	2	2	0	0	0	9	0
11	Philip Humber P. Humber	216.00	4/20/2013	HOU	vs	CLE	L	1	0	0	0	0	0.1	8	8	8	1	1	0	0	0	10	0
12	Philip Humber P. Humber	216.00	9/4/2012	CWS	vs	MIN		0	0	0	0	0	0.1	7	8	8	1	2	0	0	0	10	0
13	Madison Bumgarner M. Bumgarner	216.00	6/21/2011	SFG	vs	MIN	L	1	1	0	0	0	0.1	9	8	8	0	0	0	0	0	10	0
14	Jason Miller J. Miller	216.00	6/4/2007	MIN	@	LAA		0	0	0	0	0	0.1	7	8	8	2	2	0	0	1	10	0
15	Jesse Orosco J. Orosco	216.00	4/19/1996	BAL	@	TEX		0	0	0	0	0	0.1	6	8	8	1	2	0	0	0	9	0
16	Mark Langston M. Langston	216.00	6/4/1995	CAL	@	NYY	L	1	0	0	0	0	0.1	6	8	8	0	2	0	0	0	9	0
17	Bryn Smith B. Smith	216.00	5/16/1993	COL	@	CIN		0	0	0	0	0	0.1	6	8	8	0	2	0	0	0	9	0
18	Mike Harkey M. Harkey	216.00	7/25/1990	CHC	@	STL	L	1	0	0	0	0	0.1	6	8	8	0	2	0	0	0	9	0
19	Andy Hawkins A. Hawkins	216.00	9/26/1989	NYY	@	BOS	L	1	0	0	0	0	0.1	5	8	8	0	3	0	0	0	9	0
20	Jon Perlman J. Perlman	216.00	9/24/1985	CHC	vs	MON		0	0	0	0	0	0.1	6	8	8	2	2	0	0	1	9	0
21	Fergie Jenkins F. Jenkins	216.00	7/10/1980	TEX	vs	NYY	L	1	0	0	0	0	0.1	5	8	8	0	3	0	0	1	9	0
22	Rick Reuschel R. Reuschel	216.00	9/16/1975	CHC	vs	PIT	L	1	0	0	0	0	0.1	6	8	8	0	2	0	0	0	9	0
23	Bill Dailey B. Dailey	216.00	6/9/1964	MIN	@	DET		0	0	0	0	0	0.1	5	8	8	1	3	0	0	0	9	1
24	Lance McCullers Jr. L. McCullers Jr.	189.00	5/10/2025	HOU	vs	CIN	L	1	0	0	0	0	0.1	3	7	7	1	3	1	0	0	8	0
25	Jhonathan Díaz J. Díaz	189.00	9/15/2023	LAA	vs	DET		0	0	0	0	0	0.1	7	7	7	0	2	0	0	0	10	0