The Atlanta Braves had the highest run differential by a team in a game in 2020, with a differential of 20 runs against the Marlins on September 9, 2020.

Interpreted as:

highest run differential in a regular-season game 2020

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Braves	20	9/9/2020	ATL	vs	MIA	W 29-9	47	29	23	2	0	7	28	9	1	9	2	0	58	46	9	0	1	0	0	.489	.569	.979	1.548
2	Brewers	19	9/9/2020	MIL	@	DET	W 19-0	45	19	21	8	0	5	18	7	2	6	0	1	54	44	13	0	0	0	2	.467	.556	.978	1.533
3	Giants	18	9/1/2020	SFG	@	COL	W 23-5	52	23	27	8	1	4	23	5	1	6	1	0	59	49	13	0	1	0	0	.519	.559	.942	1.502
4	Mets	17	9/11/2020	NYM	@	TOR	W 18-1	47	18	19	5	0	3	17	6	2	10	0	0	55	33	8	0	0	0	1	.404	.491	.702	1.193
5	Nationals	15	9/20/2020	WSH	@	MIA	W 15-0	39	15	18	6	0	5	15	4	0	2	0	0	43	39	11	0	0	0	1	.462	.512	1.000	1.512
6	Brewers	15	9/15/2020	MIL	vs	STL	W 18-3	36	18	15	3	0	4	17	7	0	9	0	0	45	30	7	0	2	0	2	.417	.489	.833	1.322
7	Yankees	14	9/15/2020	NYY	vs	TOR	W 20-6	41	20	16	5	0	6	20	7	2	9	0	0	50	39	11	0	0	0	0	.390	.500	.951	1.451
8	White Sox	14	9/12/2020	CWS	vs	DET	W 14-0	42	14	19	2	0	2	14	4	0	9	0	0	47	27	4	0	1	0	2	.452	.489	.643	1.132
9	Cardinals	14	9/1/2020	STL	@	CIN	W 16-2	49	16	23	5	0	2	15	6	1	8	0	0	56	34	7	0	0	0	1	.469	.536	.694	1.230
10	Blue Jays	13	9/23/2020	TOR	vs	NYY	W 14-1	40	14	16	4	0	2	13	5	1	6	0	1	46	26	6	0	0	0	0	.400	.478	.650	1.128
11	Braves	13	9/18/2020	ATL	@	NYM	W 15-2	43	15	17	4	0	6	15	9	0	12	0	0	52	39	10	0	0	0	0	.395	.500	.907	1.407
12	Orioles	13	9/14/2020	BAL	vs	ATL	W 14-1	38	14	15	0	0	4	14	9	0	9	1	0	47	27	4	0	0	0	1	.395	.511	.711	1.221
13	Mets	13	9/6/2020	NYM	vs	PHI	W 14-1	42	14	17	7	0	5	13	2	2	14	0	1	46	39	12	0	0	1	0	.405	.457	.929	1.385
14	Angels	13	8/29/2020	LAA	vs	SEA	W 16-3	35	16	13	2	0	3	16	11	2	7	0	0	49	24	5	0	1	0	1	.371	.531	.686	1.216
15	Indians	13	8/6/2020	CLE	vs	CIN	W 13-0	35	13	11	1	1	2	13	9	0	13	0	0	44	20	4	0	0	1	0	.314	.455	.571	1.026
16	Braves	13	7/26/2020	ATL	@	NYM	W 14-1	43	14	17	7	0	4	14	5	0	6	0	0	48	36	11	0	0	0	1	.395	.458	.837	1.296
17	Orioles	12	9/24/2020	BAL	@	BOS	W 13-1	42	13	18	7	0	3	13	2	1	3	1	0	47	34	10	1	1	0	0	.429	.457	.810	1.266
18	Giants	12	9/20/2020	SFG	@	OAK	W 14-2	41	14	15	1	0	3	14	8	0	14	1	0	49	25	4	0	0	0	0	.366	.469	.610	1.079
19	Cubs	12	9/13/2020	CHC	@	MIL	W 12-0	37	12	10	4	0	1	11	7	1	8	0	0	47	17	5	0	2	0	1	.270	.383	.459	.842
20	Indians	12	8/28/2020	CLE	@	STL	W 14-2	44	14	20	4	0	3	13	7	1	5	1	0	53	33	7	0	1	0	0	.455	.528	.750	1.278
21	Athletics	12	8/16/2020	OAK	@	SFG	W 15-3	41	15	17	4	2	3	14	7	0	8	0	0	48	34	9	0	0	0	2	.415	.500	.829	1.329
22	Nationals	12	8/14/2020	WSH	@	BAL	W 15-3	44	15	19	4	1	1	15	2	1	5	1	0	50	28	6	1	2	0	0	.432	.449	.636	1.085
23	Nationals	12	8/10/2020	WSH	@	NYM	W 16-4	44	16	17	4	0	4	16	3	1	7	0	0	49	33	8	0	1	0	0	.386	.429	.750	1.179
24	Twins	12	7/26/2020	MIN	@	CWS	W 14-2	40	14	13	3	0	4	14	4	2	7	0	0	46	28	7	0	0	0	0	.325	.413	.700	1.113
25	Yankees	11	9/22/2020	NYY	@	TOR	W 12-1	40	12	15	3	1	0	11	2	1	10	1	0	43	20	4	0	0	0	2	.375	.419	.500	.919