The Chicago White Stockings have the highest run differential by a team in a game, with a differential of 31 runs against the Cleveland Blues on July 24, 1882.
Interpreted as:
highest run differential in a regular-season game with one team scoring 0 points| TEAM | DIFF | R | DATE | TM | OPP | RESULT | AB | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | White Stockings | 31 | 35 | 7/24/1882 |  CWS | vs | CLE | W 35-4 | ||||||||||||||||||||||
| 2 | | Colts | 29 | 36 | 6/29/1897 | CHI | vs | LOU | W 36-7 | ||||||||||||||||||||||
| 3 |  | Giants | 28 | 29 | 6/15/1887 |  NYG | vs |  PHN | W 29-1 | ||||||||||||||||||||||
| 4 | Grays | 28 | 28 | 8/21/1883 | PRO | vs | PHN | W 28-0 | |||||||||||||||||||||||
| 5 |  | Rangers | 27 | 30 | 8/22/2007 |  TEX | @ |  BAL | W 30-3 | 57 | 29 | 2 | 0 | 6 | 30 | 8 | 0 | 11 | 0 | 0 | 65 | 49 | 8 | 0 | 0 | 0 | 0 | .509 | .569 | .860 | 1.429 |
| 6 |  | Brewers | 27 | 30 | 9/10/1891 |  MIL | vs |  WSH | W 30-3 | ||||||||||||||||||||||
| 7 |  | Red Sox | 25 | 29 | 6/8/1950 |  BSA | vs |  SLA | W 29-4 | 53 | 28 | 9 | 1 | 7 | 29 | 11 | 0 | 2 | 0 | 0 | 64 | 60 | 17 | 0 | 0 | 0 | .528 | .609 | 1.132 | 1.741 | |
| 8 |  | Phillies | 25 | 29 | 8/17/1894 | PHI | vs | LOU | W 29-4 | ||||||||||||||||||||||
| 9 |  | Beaneaters | 25 | 29 | 6/20/1883 |  BSN | vs | PHN | W 29-4 | ||||||||||||||||||||||
| 10 | Dark Blues | 25 | 28 | 5/13/1876 | HAR | vs |  NYM | W 28-3 | |||||||||||||||||||||||
| 11 |  | Angels | 24 | 25 | 6/24/2023 |  LAA | @ |  COL | W 25-1 | 52 | 28 | 5 | 0 | 5 | 25 | 6 | 1 | 3 | 0 | 0 | 59 | 48 | 10 | 0 | 0 | 0 | 3 | .538 | .593 | .923 | 1.516 |
| 12 |  | Indians | 24 | 27 | 7/7/1923 |  CLE | vs |  BSA | W 27-3 | 43 | 24 | 5 | 2 | 0 | 25 | 14 | 1 | 1 | 4 | 2 | 61 | 33 | 7 | 3 | .558 | .672 | .767 | 1.440 | |||
| 13 | | Quakers | 24 | 24 | 6/28/1887 | PHN | @ | IND | W 24-0 | ||||||||||||||||||||||
| 14 | | Giants | 24 | 26 | 6/11/1887 | NYG | vs |  WSH | W 26-2 | ||||||||||||||||||||||
| 15 |  | Grays | 24 | 25 | 6/24/1886 |  BKN | vs |  BAL | W 25-1 | ||||||||||||||||||||||
| 16 | | Gothams | 24 | 24 | 5/27/1885 | NYG | vs | BUF | W 24-0 | ||||||||||||||||||||||
| 17 | | White Stockings | 24 | 31 | 7/3/1883 | CWS | vs | BUF | W 31-7 | ||||||||||||||||||||||
| 18 |  | Blue Jays | 23 | 28 | 7/22/2022 |  TOR | @ | BOS | W 28-5 | 57 | 29 | 5 | 0 | 5 | 28 | 5 | 1 | 9 | 0 | 0 | 63 | 49 | 10 | 0 | 0 | 0 | 0 | .509 | .556 | .860 | 1.415 |
| 19 |  | White Sox | 23 | 29 | 4/23/1955 |  CWS | @ |  KCA | W 29-6 | 54 | 29 | 5 | 0 | 7 | 28 | 6 | 1 | 4 | 1 | 1 | 63 | 55 | 12 | 0 | 2 | 1 | 0 | .537 | .571 | 1.019 | 1.590 |
| 20 | | Indians | 23 | 26 | 8/12/1948 | CLE | @ | SLA | W 26-3 | 55 | 29 | 5 | 1 | 4 | 24 | 6 | 0 | 4 | 4 | 0 | 61 | 48 | 10 | 0 | 2 | .527 | .574 | .873 | 1.446 | ||
| 21 |  | Yankees | 23 | 25 | 5/24/1936 |  NYY | @ |  PHA | W 25-2 | 45 | 19 | 3 | 3 | 6 | 25 | 16 | 0 | 5 | 0 | 0 | 61 | 46 | 12 | 0 | .422 | .574 | 1.022 | 1.596 | |||
| 22 |  | Reds | 23 | 26 | 6/4/1911 |  CIN | vs |  BSN | W 26-3 | 44 | 23 | 4 | 3 | 1 | 11 | 2 | 3 | 6 | 57 | 36 | 8 | 0 | .523 | .632 | .818 | 1.450 | |||||
| 23 |  | Pirates | 23 | 25 | 8/1/1893 |  PIT | @ |  STL | W 25-2 | ||||||||||||||||||||||
| 24 | | Colts | 23 | 28 | 8/25/1891 | CHI | vs | BKN | W 28-5 | ||||||||||||||||||||||
| 25 | | Red Stockings | 23 | 23 | 7/6/1883 | CIN | vs | BAL | W 23-0 | ||||||||||||||||||||||
Results may be incomplete. StatMuse has complete team, game-level data for runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
Brewers 
NYM 
MIA 
Padres 
Tigers 
Guardians 
Mariners 
Athletics 
BAL 
WSH 
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