Since 1960, the New York Yankees have the highest run differential by a team, with a differential of 5,699 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	5,699	10,321	.562	5,789	4,519	352,422	49,087	92,260	16,099	1,707	11,437	46,593	36,707	2,882	61,618	5,798	2,480	397,588	146,084	29,243	2,555	3,022	2,597	8,290	.262	.334	.415	.748
2	Dodgers	4,952	10,327	.550	5,673	4,648	350,468	44,619	89,982	15,214	1,976	9,310	41,992	33,845	2,618	64,119	7,181	3,117	394,525	137,078	26,500	4,802	2,792	3,447	7,419	.257	.324	.391	.716
3	Red Sox	3,062	10,321	.529	5,457	4,862	355,648	49,852	95,282	19,076	1,992	10,730	47,215	36,188	2,938	63,387	4,511	2,299	400,463	150,532	31,798	2,616	3,073	2,787	8,712	.268	.338	.423	.761
4	Cardinals	2,699	10,319	.530	5,463	4,844	351,780	45,527	92,070	16,566	2,415	8,372	42,795	33,277	2,783	63,056	7,558	3,248	394,910	138,582	27,353	4,195	2,875	3,476	7,690	.262	.328	.394	.722
5	Braves	2,220	10,311	.522	5,381	4,920	350,694	45,659	90,156	15,883	1,780	10,424	43,131	33,946	2,524	64,774	5,492	2,852	394,015	140,871	28,087	4,223	2,628	3,310	7,923	.257	.325	.402	.727
6	Giants	1,242	10,329	.517	5,333	4,990	350,862	44,864	89,195	15,843	2,279	9,463	42,118	34,327	2,706	65,917	5,694	2,876	395,089	137,985	27,585	4,448	2,746	3,774	7,674	.254	.323	.393	.716
7	Astros	715	10,013	.502	5,026	4,982	339,812	42,699	86,621	15,883	2,171	8,410	40,184	32,309	2,893	62,825	7,146	3,130	381,752	132,076	26,464	4,027	2,711	3,144	7,397	.255	.323	.389	.711
8	Reds	631	10,324	.512	5,282	5,033	351,179	45,959	90,200	16,776	2,070	10,100	43,282	34,174	2,939	68,804	7,674	3,111	395,168	141,416	28,946	4,114	2,762	3,393	7,356	.257	.326	.403	.728
9	Orioles	598	10,306	.511	5,267	5,033	351,264	46,099	90,213	16,277	1,589	10,880	43,682	34,398	2,822	63,563	5,230	2,459	394,259	142,308	28,746	2,900	2,875	2,406	8,241	.257	.326	.405	.731
10	Blue Jays	353	7,586	.498	3,777	3,806	259,903	35,059	67,582	13,507	1,491	8,239	33,253	24,098	2,423	48,869	4,568	1,962	290,043	108,788	23,237	1,497	2,122	1,397	5,916	.260	.326	.419	.745
11	Twins	-143	10,324	.497	5,124	5,192	353,662	46,725	92,798	17,042	2,302	9,360	44,005	33,218	2,980	62,640	5,381	2,767	395,695	142,524	28,704	2,901	2,934	2,514	8,387	.262	.328	.403	.731
12	Athletics	-145	10,325	.499	5,150	5,171	349,421	45,597	87,617	15,772	1,805	9,971	42,911	35,988	2,907	66,041	6,944	2,920	394,218	136,912	27,548	3,018	2,884	2,108	7,822	.251	.323	.392	.715
13	Guardians	-260	10,306	.497	5,119	5,182	351,799	46,176	91,437	16,475	1,789	9,847	43,565	33,607	2,903	61,805	6,365	3,060	394,561	141,031	28,111	3,185	3,067	2,385	8,048	.260	.327	.401	.728
14	Diamondbacks	-280	4,307	.489	2,105	2,202	146,954	19,685	37,436	7,688	1,063	4,589	18,755	14,320	1,415	32,529	2,495	898	165,213	61,017	13,340	1,323	1,201	1,088	3,074	.255	.324	.415	.740
15	White Sox	-418	10,322	.495	5,099	5,212	350,800	45,391	90,536	15,716	2,050	9,666	42,881	32,353	3,039	61,957	6,244	3,046	392,568	139,350	27,432	3,443	2,933	2,283	7,910	.258	.324	.397	.721
16	Rays	-471	4,304	.490	2,107	2,197	146,342	19,117	37,139	7,406	850	4,480	18,187	13,928	1,671	33,299	3,190	1,219	163,829	59,685	12,736	737	1,151	685	3,020	.254	.323	.408	.731
17	Phillies	-573	10,320	.497	5,124	5,190	351,355	44,794	89,427	16,440	2,444	9,318	42,173	34,314	2,868	68,671	6,441	2,634	395,222	138,709	28,202	3,935	2,750	3,484	7,274	.255	.324	.395	.718
18	Angels	-722	10,172	.495	5,034	5,135	345,124	44,001	88,307	15,265	1,808	9,193	41,403	32,273	2,817	62,600	6,042	3,097	386,517	134,767	26,266	3,536	2,767	2,482	7,870	.256	.322	.390	.713
19	Mets	-772	10,008	.484	4,839	5,161	338,616	41,299	84,618	15,117	1,815	8,566	38,886	32,371	2,853	64,854	5,873	2,734	380,442	129,063	25,498	3,987	2,615	3,137	7,449	.250	.318	.381	.699
20	Brewers	-804	8,878	.487	4,326	4,548	301,370	39,475	77,180	14,385	1,755	8,694	37,397	29,002	2,706	58,811	5,966	2,728	338,652	121,157	24,834	3,160	2,414	2,158	6,606	.256	.325	.402	.727
21	Pirates	-971	10,313	.490	5,049	5,254	352,310	43,887	91,102	16,576	2,636	8,383	41,364	30,858	2,969	66,103	6,311	3,016	393,128	138,099	27,595	4,133	2,858	3,434	7,530	.259	.321	.392	.713
22	Tigers	-1,156	10,324	.492	5,075	5,243	352,086	46,359	90,650	15,765	2,364	10,654	43,892	34,121	2,683	65,923	4,939	2,640	394,518	143,105	28,783	2,794	2,834	2,252	7,900	.257	.325	.406	.732
23	Cubs	-1,229	10,322	.484	4,985	5,320	351,714	44,754	89,675	16,134	2,250	9,857	42,183	33,058	2,766	67,598	5,455	2,805	394,322	139,880	28,241	4,112	2,672	3,266	7,536	.255	.322	.398	.719
24	Nationals	-1,457	8,873	.483	4,281	4,588	300,108	37,171	76,153	14,686	1,788	7,591	34,935	28,219	2,618	57,083	6,538	2,771	337,105	117,188	24,065	3,877	2,283	2,880	6,490	.254	.321	.390	.712
25	Mariners	-1,631	7,585	.477	3,619	3,964	258,740	33,692	66,498	12,401	1,258	7,714	32,005	24,536	2,346	49,601	5,015	2,167	289,640	104,557	21,373	1,945	2,073	1,664	5,672	.257	.325	.404	.729