Since 1970, the New York Yankees have the highest run differential by a team, with a differential of 5,080 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	5,080	8,750	.564	4,929	3,817	299,395	42,628	79,321	14,218	1,374	9,904	40,535	31,626	2,626	53,180	5,271	2,166	338,181	125,999	25,496	1,880	2,654	2,128	7,209	.265	.338	.421	.759
2	Dodgers	4,440	8,764	.550	4,822	3,939	297,892	38,551	76,833	13,357	1,582	8,338	36,459	29,103	2,326	55,808	6,096	2,572	335,586	118,368	23,277	3,865	2,400	2,886	6,350	.258	.326	.397	.724
3	Red Sox	3,504	8,757	.538	4,715	4,041	302,631	43,203	81,920	16,784	1,637	9,257	40,990	30,698	2,667	54,485	4,094	1,964	340,677	129,749	27,678	1,981	2,700	2,329	7,409	.271	.340	.429	.769
4	Cardinals	2,047	8,759	.526	4,606	4,145	298,166	39,013	78,061	14,384	1,930	7,308	36,758	28,868	2,491	54,641	6,702	2,797	335,554	118,229	23,622	3,522	2,507	2,910	6,652	.262	.330	.397	.726
5	Braves	1,733	8,749	.521	4,551	4,192	297,517	38,880	76,523	13,837	1,452	8,847	36,796	29,193	2,189	56,460	4,868	2,438	334,715	119,805	24,136	3,564	2,252	2,705	6,713	.257	.326	.403	.729
6	Astros	1,601	8,763	.514	4,502	4,259	297,963	38,360	76,677	14,390	1,856	7,758	36,194	28,402	2,605	55,919	6,637	2,803	334,804	118,053	24,004	3,399	2,435	2,680	6,476	.257	.325	.396	.721
7	Athletics	748	8,760	.511	4,477	4,283	296,686	39,512	74,724	13,748	1,369	8,958	37,290	30,932	2,574	57,213	6,123	2,566	335,004	118,084	24,075	2,291	2,521	1,744	6,710	.252	.325	.398	.723
8	Mets	587	8,756	.499	4,370	4,383	296,594	37,118	74,788	13,731	1,557	7,817	35,029	28,992	2,560	56,839	5,498	2,388	333,979	115,084	23,105	3,469	2,364	2,789	6,540	.252	.322	.388	.710
9	Blue Jays	385	7,632	.499	3,804	3,825	261,478	35,289	68,005	13,584	1,494	8,297	33,472	24,249	2,439	49,168	4,585	1,968	291,809	109,468	23,375	1,508	2,135	1,407	5,954	.260	.326	.419	.745
10	Giants	363	8,763	.508	4,453	4,309	297,600	38,018	75,711	13,923	1,914	7,901	35,783	29,419	2,328	57,425	5,139	2,496	335,405	117,165	23,738	3,690	2,368	3,146	6,467	.254	.324	.394	.718
11	Reds	166	8,764	.508	4,446	4,312	297,435	39,086	76,124	14,427	1,654	8,716	36,857	29,794	2,582	59,918	6,927	2,655	335,648	120,007	24,797	3,462	2,375	2,739	6,249	.256	.327	.403	.730
12	Guardians	54	8,739	.499	4,356	4,381	298,598	40,047	78,335	14,495	1,521	8,462	37,858	29,006	2,543	53,265	5,724	2,681	335,282	121,258	24,478	2,471	2,664	1,926	6,945	.262	.330	.406	.736
13	Phillies	-161	8,763	.502	4,393	4,366	298,814	38,685	76,426	14,410	1,997	8,166	36,532	29,602	2,531	59,026	5,900	2,213	336,468	119,328	24,573	3,131	2,390	2,893	6,176	.256	.326	.399	.725
14	Angels	-264	8,762	.499	4,376	4,385	298,244	38,895	77,078	13,612	1,502	8,245	36,684	27,826	2,544	54,184	5,544	2,750	333,855	118,429	23,359	2,817	2,424	2,085	6,886	.258	.325	.397	.722
15	Diamondbacks	-279	4,352	.489	2,128	2,224	148,491	19,918	37,838	7,762	1,074	4,660	18,985	14,466	1,438	32,874	2,524	909	166,942	61,728	13,496	1,330	1,217	1,093	3,103	.255	.325	.416	.740
16	Orioles	-343	8,742	.501	4,377	4,361	298,568	39,529	77,129	14,121	1,265	9,448	37,542	29,053	2,497	54,735	4,635	2,123	334,683	122,124	24,834	2,123	2,442	1,905	7,032	.258	.327	.409	.736
17	Rays	-393	4,351	.491	2,137	2,214	147,930	19,369	37,562	7,483	855	4,539	18,423	14,066	1,691	33,694	3,254	1,237	165,594	60,372	12,877	745	1,162	688	3,046	.254	.323	.408	.732
18	Cubs	-602	8,755	.489	4,276	4,471	298,533	38,487	76,502	14,085	1,799	8,555	36,327	28,214	2,431	58,246	4,928	2,391	334,923	119,850	24,439	3,458	2,287	2,673	6,436	.256	.323	.401	.725
19	Brewers	-606	8,760	.490	4,289	4,468	297,437	39,045	76,283	14,275	1,732	8,615	37,015	28,530	2,688	58,169	5,852	2,685	334,151	119,867	24,622	3,096	2,400	2,119	6,515	.256	.325	.403	.728
20	Twins	-892	8,756	.490	4,286	4,467	300,472	39,798	79,444	14,880	1,907	7,787	37,538	27,806	2,599	53,885	4,761	2,395	335,601	121,499	24,574	2,194	2,530	1,992	7,217	.264	.329	.404	.734
21	Rangers	-990	8,755	.486	4,251	4,499	299,744	40,616	78,416	14,341	1,575	9,064	38,426	28,381	2,457	56,559	5,460	2,544	335,493	123,099	24,980	2,390	2,521	1,913	6,679	.262	.328	.411	.739
22	White Sox	-992	8,754	.487	4,263	4,482	297,962	39,169	77,472	13,742	1,664	8,658	37,125	27,188	2,588	54,310	5,365	2,596	332,858	120,516	24,064	2,602	2,518	1,832	6,810	.260	.325	.404	.729
23	Nationals	-1,291	8,757	.485	4,246	4,507	296,224	36,780	75,223	14,566	1,759	7,513	34,577	27,812	2,604	56,450	6,516	2,737	332,732	115,846	23,838	3,828	2,264	2,833	6,391	.254	.321	.391	.712
24	Pirates	-1,550	8,752	.483	4,221	4,525	298,247	37,252	76,554	14,474	2,082	7,268	35,213	26,697	2,681	57,477	5,740	2,634	333,522	116,996	23,824	3,431	2,466	2,738	6,278	.257	.321	.392	.713
25	Mariners	-1,648	7,631	.477	3,640	3,989	260,327	33,883	66,890	12,467	1,260	7,770	32,192	24,666	2,370	50,022	5,054	2,177	291,398	105,187	21,497	1,951	2,084	1,669	5,699	.257	.325	.404	.729