The Houston Astros put up their most runs in a game versus the Orioles on August 10, 2019, with 23 runs.

Interpreted as:

highest scoring regular-season game by astros

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	23	8/10/2019	HOU	@	BAL	W 23-2	50	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
2	Astros	21	8/18/2022	HOU	@	CWS	W 21-5	51	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
3	Astros	21	9/8/2019	HOU	vs	SEA	W 21-1	47	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
4	Astros	21	10/2/2015	HOU	@	ARI	W 21-5	46	19	4	1	4	18	8	0	8	1	0	57	37	9	1	2	1	0	.413	.482	.804	1.286
5	Astros	19	7/9/2017	HOU	@	TOR	W 19-1	45	17	4	0	5	16	8	1	7	1	0	54	36	9	0	0	0	1	.378	.481	.800	1.281
6	Astros	19	5/11/1999	HOU	vs	PIT	W 19-8	43	18	10	0	0	19	8	2	5	1	0	54	28	10	0	1	1	0	.419	.519	.651	1.170
7	Astros	19	6/25/1995	HOU	vs	CHC	W 19-6	41	19	3	0	2	19	9	0	2	4	0	52	28	5	0	2	2	1	.463	.538	.683	1.221
8	Astros	18	8/3/2010	HOU	@	STL	W 18-4	45	22	4	1	0	17	5	0	5	0	0	53	28	5	1	2	0	1	.489	.519	.622	1.141
9	Astros	18	9/20/2007	HOU	@	STL	W 18-1	48	23	5	0	1	16	6	2	3	0	0	57	31	6	1	0	1	2	.479	.554	.646	1.199
10	Astros	18	8/26/2003	HOU	vs	LAD	W 18-4	40	17	5	1	2	17	9	0	8	2	0	49	30	8	0	0	0	1	.425	.531	.750	1.281
11	Astros	18	4/29/1974	HOU	vs	CHC	W 18-2	43	20	1	1	2	14	6	0	6	4	0	51	29	4	0	2	0	0	.465	.510	.674	1.184
12	Astros	18	7/7/1971	HOU	@	SFG	W 18-4	45	17	6	0	0	18	4	1	5	2	0	51	23	6	0	1	0	0	.378	.431	.511	.942
13	Astros	17	8/27/2023	HOU	@	DET	W 17-4	52	25	4	1	4	16	6	0	5	0	0	58	43	9	0	0	0	1	.481	.534	.827	1.361
14	Astros	17	7/29/2023	HOU	vs	TBR	W 17-4	42	18	3	1	5	17	6	0	7	0	0	48	38	9	0	0	0	0	.429	.500	.905	1.405
15	Astros	17	5/31/2017	HOU	@	MIN	W 17-6	44	19	2	0	6	16	7	0	3	1	0	52	39	8	0	1	1	0	.432	.500	.886	1.386
16	Astros	17	5/13/2002	HOU	vs	PHI	W 17-3	45	20	8	1	0	15	4	0	7	0	1	49	30	9	0	0	0	0	.444	.490	.667	1.156
17	Astros	17	7/18/2001	HOU	vs	STL	W 17-11	37	16	5	2	4	16	7	2	8	1	0	49	37	11	2	1	0	0	.432	.532	1.000	1.532
18	Astros	17	6/30/1998	HOU	vs	CWS	W 17-2	39	18	3	0	4	17	3	0	7	0	0	43	33	7	0	1	0	2	.462	.488	.846	1.335
19	Astros	17	8/20/1985	HOU	vs	STL	W 17-2	42	19	4	2	2	14	5	0	4	0	0	47	33	8	0	0	1	1	.452	.511	.786	1.296
20	Astros	17	8/17/1972	HOU	@	MON	W 17-5	46	20	4	0	4	17	7	0	11	0	0	54	36	8	1	0	0	0	.435	.509	.783	1.292
21	Astros	17	6/7/1967	HOU	@	STL	W 17-1	48	23	4	1	0	17	5	0	5	1	0	56	29	5	2	1	0	0	.479	.519	.604	1.123
22	Astros	17	5/26/1967	HOU	@	CHC	W 17-4	41	15	5	0	4	17	6	2	6	2	0	50	32	9	1	0	1	1	.366	.469	.780	1.250
23	Astros	16	4/24/2021	HOU	vs	LAA	W 16-2	42	18	7	1	3	14	5	1	7	0	0	48	36	11	0	0	1	2	.429	.500	.857	1.357
24	Astros	16	5/7/2018	HOU	@	OAK	W 16-2	45	20	5	0	3	14	6	0	4	0	0	51	34	8	0	0	0	2	.444	.510	.756	1.265
25	Astros	16	8/4/2017	HOU	vs	TOR	W 16-7	40	18	5	0	5	16	7	0	1	0	0	47	38	10	0	0	0	2	.450	.532	.950	1.482