Johan Santana had a 46-34 record with an ERA of 3.18 and 607 strikeouts in 109 appearances for the Mets in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Santana | 2008 |  NYM | 34 | 16 | 7 | .696 | 34 | 2.53 | 206 | 3 | 2 | 0 | 234.1 | 206 | 66 | 74 | 23 | 63 | 4 | 0 | 5 | 964 | 9 | 7.91 | 2.42 | 3.27 | 0.88 | 21.4 | 6.5 | 1.15 | .274 | 2.84 | 61 | 3.50 | 82 | 7.91 | 20.2 |
| 2 | | J. Santana | 2009 | NYM | 25 | 13 | 9 | .591 | 25 | 3.13 | 146 | 0 | 0 | 0 | 166.2 | 156 | 58 | 67 | 20 | 46 | 3 | 0 | 3 | 701 | 1 | 7.88 | 2.48 | 3.17 | 1.08 | 20.8 | 6.6 | 1.21 | .280 | 3.62 | 77 | 3.78 | 91 | 8.42 | 6.8 |
| 3 | | J. Santana | 2010 | NYM | 29 | 11 | 9 | .550 | 29 | 2.98 | 144 | 4 | 2 | 0 | 199.0 | 179 | 66 | 67 | 16 | 55 | 2 | 0 | 2 | 817 | 2 | 6.51 | 2.49 | 2.62 | 0.72 | 17.6 | 6.7 | 1.18 | .272 | 3.03 | 77 | 3.53 | 90 | 8.10 | 8.5 |
| 4 | | J. Santana | 2012 | NYM | 21 | 6 | 9 | .400 | 21 | 4.85 | 111 | 2 | 2 | 0 | 117.0 | 117 | 63 | 65 | 17 | 39 | 0 | 0 | 1 | 499 | 1 | 8.54 | 3.00 | 2.85 | 1.31 | 22.2 | 7.8 | 1.33 | .301 | 5.00 | 129 | 4.08 | 105 | 9.00 | -2.3 |
| Total | 109 | 46 | 34 | .575 | 109 | 3.18 | 607 | 9 | 6 | 0 | 717.0 | 658 | 253 | 273 | 76 | 203 | 9 | 0 | 11 | 2,981 | 13 | 7.62 | 2.55 | 2.99 | 0.95 | 20.4 | 6.8 | 1.20 | .279 | 3.43 | 80 | 3.67 | 90 | 8.26 | 33.1 |
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