The Cincinnati Reds had the highest run differential by a team in a game in 2025, with a differential of 22 runs against the Orioles on April 20, 2025.
Interpreted as:
largest margin of victory in an MLB regular-season game 2025| TEAM | DIFF | DATE | TM | OPP | RESULT | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Reds | 22 | 4/20/2025 | @ | W 24-2 | 51 | 24 | 25 | 4 | 1 | 3 | 23 | 11 | 2 | 6 | 1 | 0 | 64 | 40 | 8 | 0 | 0 | 0 | 1 | .490 | .594 | .784 | 1.378 | ||
| 2 |  | Padres | 21 | 5/10/2025 | @ | W 21-0 | 50 | 21 | 24 | 4 | 1 | 5 | 20 | 5 | 0 | 4 | 0 | 0 | 56 | 45 | 10 | 0 | 1 | 0 | 0 | .480 | .518 | .900 | 1.418 | ||
| 3 |  | Royals | 19 | 9/19/2025 | vs | W 20-1 | 51 | 20 | 27 | 7 | 0 | 3 | 20 | 5 | 0 | 6 | 1 | 0 | 56 | 43 | 10 | 0 | 0 | 0 | 0 | .529 | .571 | .843 | 1.415 | ||
| 4 |  | Blue Jays | 19 | 8/6/2025 | @ | W 20-1 | 49 | 20 | 24 | 7 | 1 | 5 | 20 | 4 | 2 | 6 | 0 | 0 | 57 | 48 | 13 | 0 | 2 | 0 | 0 | .490 | .526 | .980 | 1.506 | ||
| 5 |  | Orioles | 18 | 7/26/2025 | vs | W 18-0 | 40 | 18 | 18 | 4 | 0 | 3 | 16 | 6 | 1 | 4 | 1 | 0 | 47 | 31 | 7 | 0 | 0 | 0 | 3 | .450 | .532 | .775 | 1.307 | ||
| 6 |  | Rangers | 17 | 8/27/2025 | vs | W 20-3 | 46 | 20 | 22 | 5 | 0 | 4 | 20 | 4 | 2 | 6 | 0 | 0 | 53 | 39 | 9 | 0 | 1 | 0 | 0 | .478 | .528 | .848 | 1.376 | ||
| 7 |  | Astros | 17 | 7/4/2025 | @ | W 18-1 | 44 | 18 | 20 | 6 | 0 | 5 | 17 | 8 | 1 | 8 | 0 | 1 | 54 | 41 | 11 | 0 | 1 | 1 | 1 | .455 | .537 | .932 | 1.469 | ||
| 8 |  | Dodgers | 17 | 5/15/2025 | vs | W 19-2 | 40 | 19 | 18 | 2 | 0 | 5 | 19 | 8 | 0 | 6 | 2 | 0 | 50 | 35 | 7 | 0 | 2 | 0 | 0 | .450 | .520 | .875 | 1.395 | ||
| 9 |  | Mariners | 16 | 9/7/2025 | @ | W 18-2 | 45 | 18 | 19 | 1 | 1 | 5 | 14 | 3 | 2 | 7 | 2 | 0 | 51 | 37 | 7 | 0 | 1 | 0 | 1 | .422 | .471 | .822 | 1.293 | ||
| 10 | | Dodgers | 16 | 5/31/2025 | vs | W 18-2 | 43 | 18 | 21 | 5 | 0 | 5 | 18 | 7 | 0 | 5 | 0 | 0 | 51 | 41 | 10 | 0 | 1 | 0 | 1 | .488 | .549 | .953 | 1.503 | ||
| 11 |  | Cubs | 16 | 4/12/2025 | @ | W 16-0 | 47 | 16 | 21 | 5 | 0 | 4 | 16 | 4 | 1 | 4 | 1 | 0 | 53 | 38 | 9 | 0 | 1 | 0 | 0 | .447 | .491 | .809 | 1.299 | ||
| 12 |  | Phillies | 15 | 8/28/2025 | vs | W 19-4 | 44 | 19 | 20 | 3 | 1 | 7 | 19 | 4 | 0 | 3 | 0 | 0 | 48 | 46 | 11 | 0 | 0 | 0 | 0 | .455 | .500 | 1.045 | 1.545 | ||
| 13 |  | Rays | 15 | 4/14/2025 | vs | W 16-1 | 40 | 16 | 16 | 2 | 0 | 4 | 16 | 4 | 0 | 9 | 1 | 0 | 44 | 30 | 6 | 0 | 0 | 0 | 1 | .400 | .455 | .750 | 1.205 | ||
| 14 |  | Brewers | 15 | 4/9/2025 | @ | W 17-2 | 40 | 17 | 13 | 2 | 0 | 3 | 15 | 5 | 0 | 6 | 3 | 0 | 46 | 24 | 5 | 0 | 1 | 0 | 1 | .325 | .391 | .600 | .991 | ||
| 15 | | Cubs | 15 | 3/31/2025 | @ | W 18-3 | 48 | 18 | 21 | 6 | 1 | 4 | 18 | 10 | 1 | 7 | 0 | 0 | 60 | 41 | 11 | 0 | 1 | 0 | 0 | .438 | .533 | .854 | 1.388 | ||
| 16 | | Brewers | 14 | 8/12/2025 | vs | W 14-0 | 40 | 14 | 15 | 4 | 0 | 5 | 14 | 5 | 0 | 8 | 0 | 0 | 46 | 34 | 9 | 0 | 1 | 0 | 0 | .375 | .435 | .850 | 1.285 | ||
| 17 | | Blue Jays | 14 | 8/4/2025 | @ | W 15-1 | 50 | 15 | 25 | 4 | 1 | 3 | 15 | 3 | 0 | 5 | 0 | 0 | 53 | 40 | 8 | 0 | 0 | 0 | 2 | .500 | .528 | .800 | 1.328 | ||
| 18 |  | Red Sox | 14 | 6/28/2025 | vs | W 15-1 | 40 | 15 | 18 | 6 | 0 | 3 | 14 | 6 | 2 | 7 | 2 | 0 | 50 | 33 | 9 | 0 | 2 | 0 | 0 | .450 | .520 | .825 | 1.345 | ||
| 19 | | Orioles | 14 | 6/27/2025 | vs | W 22-8 | 46 | 22 | 21 | 9 | 1 | 4 | 20 | 8 | 1 | 9 | 2 | 0 | 55 | 44 | 14 | 0 | 0 | 0 | 0 | .457 | .545 | .957 | 1.502 | ||
| 20 | | Red Sox | 14 | 5/23/2025 | vs | W 19-5 | 45 | 19 | 20 | 6 | 0 | 3 | 19 | 8 | 0 | 7 | 0 | 0 | 53 | 35 | 9 | 0 | 0 | 0 | 1 | .444 | .528 | .778 | 1.306 | ||
| 21 | | Blue Jays | 14 | 5/21/2025 | vs | W 14-0 | 40 | 14 | 14 | 3 | 0 | 2 | 13 | 3 | 2 | 7 | 1 | 0 | 46 | 23 | 5 | 1 | 0 | 0 | 0 | .350 | .422 | .575 | .997 | ||
| 22 |  | Mets | 14 | 4/28/2025 | @ | W 19-5 | 47 | 19 | 21 | 3 | 1 | 4 | 19 | 6 | 2 | 9 | 0 | 0 | 56 | 38 | 8 | 0 | 1 | 0 | 0 | .447 | .518 | .809 | 1.326 | ||
| 23 | | Mariners | 14 | 4/26/2025 | vs | W 14-0 | 37 | 14 | 15 | 3 | 0 | 4 | 14 | 7 | 1 | 6 | 0 | 0 | 46 | 30 | 7 | 0 | 1 | 0 | 0 | .405 | .500 | .811 | 1.311 | ||
| 24 |  | Athletics | 13 | 9/6/2025 | @ | W 17-4 | 49 | 17 | 21 | 4 | 0 | 4 | 17 | 6 | 1 | 8 | 1 | 0 | 56 | 37 | 8 | 0 | 0 | 0 | 0 | .429 | .500 | .755 | 1.255 | ||
| 25 | | Red Sox | 13 | 8/12/2025 | @ | W 14-1 | 40 | 14 | 13 | 2 | 0 | 3 | 14 | 8 | 2 | 5 | 2 | 0 | 51 | 24 | 5 | 0 | 1 | 0 | 0 | .325 | .451 | .600 | 1.051 | ||
CIN
BAL
SDP
COL
KCR
TOR
TEX
LAA
HOU
LAD
ATH
SEA
ATL
NYY
CHC
PHI
TBR
BOS
MIL
PIT
NYM
WSH
MIASome of the information used here was obtained free of charge from Retrosheet.
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More Reds Stats
Team Batting Leaders 
HR
31
Stewart
RBI
106
Stewart
AVG
.276
De La Cruz
Team Pitching Leaders 
W
15
Burns
K
171
Burns
ERA
2.79
Burns
Team Rankings
HR
188
4th
R
588
24th
SO
1,140
23rd
ERA
4.68
26th
Cardinals
MLB 2026 Batting Leaders
MLB 2026 Pitching Leaders
MLB Fantasy 2026
MLB 2026 Betting
MLB 2026 Standings
| NL East | W | L | PCT | GB |
|---|---|---|---|---|
84 | 57 | .596 | ||
79 | 62 | .560 | 5.0 | |
71 | 71 | .500 | 13.5 | |
67 | 76 | .469 | 18.0 | |
64 | 77 | .454 | 20.0 | |
| NL Central | W | L | PCT | GB |
88 | 54 | .620 | ||
80 | 62 | .563 | 8.0 | |
71 | 71 | .500 | 17.0 | |
70 | 72 | .493 | 18.0 | |
67 | 74 | .475 | 20.5 | |
| NL West | W | L | PCT | GB |
84 | 57 | .596 | ||
74 | 67 | .525 | 10.0 | |
74 | 68 | .521 | 10.5 | |
58 | 84 | .408 | 26.5 | |
54 | 87 | .383 | 30.0 |
Diamondbacks
Giants| AL East | W | L | PCT | GB |
|---|---|---|---|---|
84 | 57 | .596 | ||
80 | 61 | .567 | 4.0 | |
77 | 65 | .542 | 7.5 | |
71 | 71 | .500 | 13.5 | |
69 | 73 | .486 | 15.5 | |
| AL Central | W | L | PCT | GB |
74 | 67 | .525 | ||
72 | 70 | .507 | 2.5 | |
67 | 74 | .475 | 7.0 | |
64 | 77 | .454 | 10.0 | |
63 | 79 | .444 | 11.5 | |
| AL West | W | L | PCT | GB |
73 | 69 | .514 | ||
70 | 72 | .493 | 3.0 | |
66 | 76 | .465 | 7.0 | |
56 | 86 | .394 | 17.0 | |
53 | 88 | .376 | 19.5 |
White Sox
Guardians
Twins
Tigers