Leon Cadore and Joe Oeschger are tied for the lowest ERA in a game with an ERA worse than 0.00, with an ERA of 0.35 on May 1, 1920.

Interpreted as:

lowest era by a player above zero in a regular-season game

	NAME	ERA	DATE	TM		OPP	DEC	GS	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Leon Cadore L. Cadore	0.35	5/1/1920	BKN	@	BSN		1	7	1	0	0	26.0	15	1	1	0	5	0	0		96	0
2	Joe Oeschger J. Oeschger	0.35	5/1/1920	BSN	vs	BKN		1	7	1	0	0	26.0	9	1	1	0	4	0	0		90	1
3	Rube Marquard R. Marquard	0.43	7/17/1914	NYG	@	PTN	W	1	2	1	0	0	21.0	15	1	1	0	2	1	0		79	0
4	Vern Law V. Law	0.50	7/19/1955	PIT	vs	MIL		1	12	0	0	0	18.0	9	1	2	1	2	0	0	0	64	1
5	Lefty Williams L. Williams	0.52	5/15/1918	CWS	@	WSH	L	1	3	1	0	0	17.1	8	1	1	0	2	1	0		63	1
6	Roy Parmelee R. Parmelee	0.53	4/29/1936	SLN	vs	NYG	W	1	9	1	0	0	17.0	6	1	1	0	4	0	0		57	0
7	Grover Alexander G. Alexander	0.53	10/1/1920	CHC	vs	SLN	W	1	8	1	0	0	17.0	16	1	2	0	3	0	0		69	0
8	Elmer Jacobs E. Jacobs	0.54	8/22/1917	PIT	@	BKN	L	0	1	0	0	0	16.2	17	1	1	0	3	0	1		66	0
9	Carl Hubbell C. Hubbell	0.55	4/29/1936	NYG	@	SLN	L	1	6	1	0	0	16.1	11	1	2	0	4	0	0		64	0
10	Bill Dinneen B. Dinneen	0.55	9/21/1901	BSN	@	CHO	L	1	7	1	0	0	16.1	8	1	1	0	1	1	0		61	0
11	Tom Cheney T. Cheney	0.56	9/12/1962	WSH	@	BAL	W	1	21	1	0	0	16.0	10	1	1	0	4	0	0	0	62	1
12	Billy Pierce B. Pierce	0.56	8/6/1959	CWS	@	BAL		1	7	0	0	0	16.0	11	1	1	0	3	0	0	2	61	0
13	Johnny Antonelli J. Antonelli	0.56	5/1/1955	NYG	vs	CIN	W	1	11	1	0	0	16.0	6	1	1	0	5	2	0	0	57	0
14	Dick Fowler D. Fowler	0.56	6/5/1942	PHA	vs	SLA	L	1	6	1	0	0	16.0	9	1	1	0	5	0	0		61	0
15	Paul Derringer P. Derringer	0.56	6/22/1941	CIN	vs	BKN	L	1	4	1	0	0	16.0	13	1	2	1	4	0	0		62	0
16	Eppa Rixey E. Rixey	0.56	7/8/1924	CIN	vs	PHN	W	1	3	1	0	0	16.0	8	1	1	0	4	0	0		56	0
17	Eric Erickson E. Erickson	0.56	5/24/1918	DET	@	WSH		1	12	1	0	0	16.0	8	1	2	0	0	0	0		55	0
18	Doc Ayers D. Ayers	0.56	9/12/1917	WSH	vs	BSA		1	5	1	0	0	16.0	13	1	1	0	3	0	0		59	0
19	Ernie Shore E. Shore	0.56	9/12/1917	BSA	@	WSH		1	2	1	0	0	16.0	6	1	1	0	5	0	0		57	0
20	Frank Miller F. Miller	0.56	5/31/1916	PIT	vs	CIN	L	1	7	1	0	0	16.0	11	1	5	0	5	2	0		64	0
21	Elmer Knetzer E. Knetzer	0.56	10/9/1914	PTF	vs	BUF	L	1	9	1	0	0	16.0	15	1	1	0	5	0	0		65	0
22	Ad Brennan A. Brennan	0.56	7/19/1913	PHN	vs	CIN	W	1	3	1	0	0	16.0	8	1	2	0	0	0	0		55	0
23	Bill Dinneen B. Dinneen	0.56	6/12/1904	BSA	@	SLA	W	1	9	1	0	0	16.0	13	1	1	0	4	0	0		60	0
24	Roscoe Miller R. Miller	0.56	7/3/1901	DET	@	MIL	W	1	1	1	0	0	16.0	13	1	5	0	4	0	0		65	0
25	Warren Spahn W. Spahn	0.57	4/23/1951	BSN	@	BKN	L	1	8	1	0	0	15.2	10	1	2	1	2	0	0	1	56	0