Since 1947, the San Diego Padres have the lowest run differential by a team, with a differential of -2,833 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	-2,833	8,891	.467	4,154	4,735	300,568	36,045	74,962	13,262	1,760	7,259	33,894	28,613	2,125	59,453	6,004	2,603	337,264	113,521	22,281	3,710	2,248	2,686	6,501	.249	.317	.378	.695
2	Pirates	-2,657	12,338	.478	5,884	6,432	421,099	52,154	108,684	19,266	3,314	9,861	49,091	37,389	3,292	75,127	6,798	3,269	470,061	164,161	32,441	5,166	3,115	3,698	9,104	.258	.321	.390	.711
3	Cubs	-2,524	12,347	.476	5,857	6,460	420,912	53,022	107,300	18,932	2,869	11,589	49,945	39,103	3,113	77,318	6,029	3,070	470,989	166,737	33,390	4,953	2,908	3,521	9,075	.255	.321	.396	.717
4	Marlins	-2,221	5,058	.459	2,322	2,736	171,929	21,287	43,802	8,333	984	4,608	20,183	15,546	1,834	38,289	3,254	1,293	192,302	67,927	13,925	1,717	1,276	1,203	3,797	.255	.321	.395	.716
5	Royals	-2,156	8,882	.477	4,235	4,645	303,800	38,835	79,776	14,913	2,291	7,003	36,651	26,000	2,458	52,127	7,090	2,896	337,295	120,280	24,207	2,369	2,668	1,868	6,779	.263	.323	.396	.719
6	Rangers	-2,081	10,174	.476	4,843	5,325	347,305	45,776	89,579	15,964	1,891	10,197	43,254	32,890	2,699	65,167	5,944	2,846	388,689	139,916	28,052	2,963	2,832	2,250	7,795	.258	.324	.403	.727
7	Twins	-1,933	12,344	.482	5,945	6,382	421,684	54,748	109,703	19,655	2,956	10,448	51,538	40,701	3,366	71,281	5,947	3,079	472,737	166,614	33,059	3,821	3,165	2,663	10,110	.260	.328	.395	.723
8	Rockies	-1,898	5,067	.460	2,329	2,738	174,021	25,066	47,012	9,284	1,308	5,728	23,836	15,984	1,581	37,714	3,054	1,366	194,946	76,096	16,320	2,003	1,357	1,209	3,864	.270	.335	.437	.772
9	Athletics	-1,765	12,350	.488	6,019	6,315	417,929	54,117	105,034	18,547	2,383	11,349	50,889	43,417	3,246	74,337	7,433	3,207	471,755	162,394	32,279	4,060	3,103	2,269	9,599	.251	.324	.389	.713
10	Mariners	-1,632	7,597	.477	3,626	3,969	259,147	33,739	66,588	12,416	1,258	7,728	32,052	24,569	2,350	49,722	5,021	2,169	290,089	104,704	21,402	1,947	2,076	1,664	5,678	.257	.325	.404	.729
11	Orioles	-1,541	12,327	.493	6,072	6,239	419,406	53,761	107,116	18,987	2,099	12,050	50,829	41,598	3,101	72,633	5,757	2,782	471,256	166,451	33,136	4,050	3,101	2,575	9,959	.255	.325	.397	.722
12	Nationals	-1,478	8,886	.483	4,286	4,596	300,537	37,227	76,257	14,710	1,789	7,605	34,989	28,256	2,626	57,187	6,549	2,776	337,584	117,360	24,104	3,879	2,286	2,881	6,501	.254	.321	.391	.712
13	Tigers	-1,176	12,355	.492	6,072	6,261	421,472	55,510	108,984	18,708	2,919	12,120	52,477	42,005	3,002	73,667	5,424	2,937	473,507	169,890	33,747	3,920	3,108	2,447	9,691	.259	.328	.403	.731
14	Brewers	-820	8,890	.487	4,331	4,555	301,753	39,508	77,256	14,401	1,756	8,702	37,430	29,040	2,710	58,920	5,984	2,731	339,080	121,275	24,859	3,162	2,415	2,158	6,609	.256	.325	.402	.726
15	Phillies	-807	12,345	.496	6,110	6,219	420,100	53,333	107,166	19,329	3,096	10,756	50,124	41,342	3,217	77,308	7,071	2,914	472,560	164,955	33,181	4,887	3,014	3,739	8,895	.255	.324	.393	.717
16	Mets	-775	10,020	.484	4,845	5,167	338,998	41,339	84,706	15,134	1,817	8,578	38,924	32,411	2,858	64,956	5,886	2,734	380,874	129,208	25,529	3,988	2,619	3,137	7,461	.250	.318	.381	.699
17	Angels	-716	10,185	.495	5,042	5,140	345,558	44,069	88,409	15,284	1,810	9,216	41,467	32,316	2,823	62,735	6,044	3,100	387,004	134,961	26,310	3,537	2,770	2,483	7,877	.256	.322	.391	.713
18	Rays	-484	4,317	.489	2,112	2,205	146,776	19,168	37,240	7,419	850	4,492	18,235	13,959	1,673	33,415	3,210	1,225	164,301	59,835	12,761	737	1,156	685	3,025	.254	.323	.408	.731
19	Diamondbacks	-278	4,320	.489	2,113	2,207	147,394	19,757	37,560	7,716	1,066	4,612	18,825	14,366	1,423	32,611	2,507	902	165,714	61,244	13,394	1,325	1,206	1,090	3,083	.255	.325	.416	.740
20	White Sox	-48	12,351	.498	6,134	6,190	419,546	54,071	108,361	18,394	2,653	10,803	50,986	39,970	3,622	69,686	7,266	3,482	470,989	164,470	31,850	4,631	3,220	2,461	9,582	.258	.326	.392	.718
21	Reds	181	12,342	.505	6,229	6,099	420,376	54,919	108,202	19,799	2,537	11,878	51,709	40,800	3,263	77,440	8,265	3,405	472,578	168,709	34,214	5,102	3,037	3,646	8,838	.257	.326	.401	.727
22	Blue Jays	358	7,598	.498	3,783	3,812	260,321	35,118	67,699	13,530	1,491	8,256	33,311	24,137	2,423	48,968	4,573	1,963	290,506	108,979	23,277	1,500	2,125	1,401	5,927	.260	.326	.419	.745
23	Astros	727	10,026	.502	5,034	4,987	340,240	42,755	86,730	15,906	2,172	8,422	40,238	32,356	2,898	62,914	7,148	3,135	382,237	132,246	26,500	4,030	2,713	3,144	7,408	.255	.323	.389	.711
24	Guardians	1,358	12,330	.511	6,294	6,020	420,523	55,741	109,382	19,211	2,287	11,776	52,601	41,484	3,293	70,763	6,895	3,388	472,937	168,495	33,274	4,283	3,354	2,545	9,627	.260	.329	.401	.730
25	Giants	1,953	12,351	.518	6,393	5,947	420,055	54,322	107,171	18,500	2,885	11,640	51,002	41,278	3,096	74,451	6,322	3,145	472,786	166,361	33,025	5,342	3,015	4,018	9,140	.255	.324	.396	.720